Tältä sivulta löydät kaikki FinnGen-aineistoa hyödyntäneet julkaisut ja preprint-artikkelit.
2025

Heinäkuu

Circulating Inflammatory Proteins in Drug-Induced Anaphylactic Shock: Evidence from Multivariable Mendelian Randomization and Multi-Omics Integration
Dai J, Sun N, Xu W, Zuo Z, Pang X, Qian Z.
Shock. 2025 Jul 10. doi: 10.1097/SHK.0000000000002644.
Genetic prioritisation of candidate drug targets for glaucoma through multi-trait and multi-omics integration
Jianqi Chen, Yangjiani Li, Yingting Zhu, Zhidong Li, Shitong Huang, Wenzhi Huang, Yuyao Ling, Jingying Liang, Yunxia Leng & Yehong Zhuo
Eye and Vis 12, 26 (2025). https://doi.org/10.1186/s40662-025-00442-4
Mendelian randomization analysis provides insights into the relationship between inflammatory bowel disease and skin cancer
Rashid S, Usoltsev D, Gupta S, Artomov M, Tsao H.
Mol Clin Oncol. 2025 Jul 10;23(3):83. doi: 10.3892/mco.2025.2878.
Risk Factors of Periodontitis: Evidence From Two-Sample Mendelian Randomization and Meta-Analysis
Yan L, Liu Z, Xie B, Huang Y, Wu Y, He B, Li Y, Luo L, Yan F, Chen F.
J Periodontal Res. 2025 Jul 10. doi: 10.1111/jre.70001.
Integrative multiomics elucidate crotonylation-associated GCDH in Parkinson’s disease pathogenesis via metabolome remodeling
Jia Fu, Jing Zhao, Na Mi, Chao Zhang, Yali Zhang, Lifen Yao
Mamm Genome 36, 1215–1225 (2025). https://doi.org/10.1007/s00335-025-10151-x
The causal relationship between immune cell phenotypes and esophageal cancer development: a bidirectional Mendelian randomization study
Xun Zhang, Hailang Zhou, Qianqian Meng, Weiyi Wang, Lu Zhou, Ying Xu, Haiqin Zhang, Zixu Zhang, Jinnian Cheng, Xiaopeng Zhan, Ji Li, Changping Hu, Fengli Zhou, Daming Yang, Luowei Wang, Yimin Chu, Haixia Peng
Discov Onc 16, 1304 (2025). https://doi.org/10.1007/s12672-025-03175-x
Genetic Association Between Sleep Traits and Vertigo Risk: A Two-Sample Bidirectional Mendelian Randomization Study
Xu W, Tian E, Wang J, Yu X, Guo Z, Chen J, Zhang S.
Curr Mol Med. 2025 Jul 10. doi: 10.2174/0115665240358943250612115854.
Relationship between Tic disorders and 41 inflammatory factors in circulating blood: a two-sample Mendelian randomization study
Lai C, Huang G, Chen X, Lian X, Li X, He W, Luo G, Cai A.
Clinics (Sao Paulo). 2025 Jul 10;80:100649. doi: 10.1016/j.clinsp.2025.100649.
Large-scale evaluation of proteomic and polygenic risk scores reveals complementary contributions to incident disease prediction
Woerner J, Westbrook TM, Joo J, Shivakumar M, Venkatesh R, Cherlin T, Jung S-H, Jeong S, Maseda D, McKeague M, Shwetank, Ionita M, Wagenaar J, Abramowitz SA, Verma A, Zhao B, Lee S, Damrauer S, Levin MG, Heo SC, Cappola TP, Rader DJ, Day S, Deo R, Gelfand JM, Ramessur R, Guerraty MA, Setia-Verma S, Pasaniuc B, Ritchie MD, Apostolidis SA, Greenplate AR, Wherry EJ, Penn Medicine Biobank, Nam Y, Kim D.
medRxiv 2025.07.10.25331242; doi: https://doi.org/10.1101/2025.07.10.25331242
Serum carnitine and cancer risk: a Mendelian randomization study identifying pancreatic cancer as a modifiable metabolic target
Xiaoqing Zhou, Yujie Zhou, Yingnan Xu, Zhen Wang, Xin Lv
Discov Onc 16, 1300 (2025). https://doi.org/10.1007/s12672-025-03161-3
Haplotype analysis reveals pleiotropic disease associations in the HLA region
Smith CJ, Strausz S; FinnGen; Spence JP, Ollila HM, Pritchard JK.
Am J Hum Genet. 2025 Jul 8:S0002-9297(25)00242-3. doi: 10.1016/j.ajhg.2025.06.011.
Exploring the impact of diet, sleep, and metabolomic pathways on Glaucoma subtypes: insights from Mendelian randomization and cross-sectional analyses
Zhang Shengnan, Wang Tao, Zhang Yanan, Sun Chao
Nutr Metab (Lond) 22, 74 (2025). https://doi.org/10.1186/s12986-025-00967-4
EP300 Regulates CD8br AC (TBNK Panel) to Facilitate Insomnia
Men X, Wang Q.
Mol Neurobiol. 2025 Jul 9. doi: 10.1007/s12035-025-05188-7.
Immune cells mediate the association between the plasma lipidome and pancreatic cancer: a Mendelian randomization analysis
Chunhong Ma, Dandan Liu, Changchun Ye, Zilu Chen, Ranran Kong, Jianzhong Li, Xuejun Sun, Zhengshui Xu
Sci Rep 15, 24451 (2025). https://doi.org/10.1038/s41598-025-05898-x
Borzoi-informed fine mapping improves causal variant prioritization in complex trait GWAS
Srivastava D, Korsakova A, Wang Q, Ruiz L, Yuan H, Kelley DR.
bioRxiv 2025.07.09.663936; doi: https://doi.org/10.1101/2025.07.09.663936
Low-density lipoprotein cholesterol mediates the causal association between systemic lupus erythematosus and asthma: a mediation mendelian randomization study
Hui Yin, Tongxia Wang, Lin Liu, Zhi Hu
BMC Rheumatol 9, 85 (2025). https://doi.org/10.1186/s41927-025-00539-2
The Causal Relationship Between Atrial Fibrillation and Work and Sleep
Wu X, Liu F, Jin L, Huo M, Chen J, Song R, Shi X, Gao H.
Int Heart J. 2025 Jul 9. doi: 10.1536/ihj.24-660.
Dissecting the pleiotropic genetic architecture linking telomere biology to chronic respiratory diseases and lung function
Zhang P, Zheng L, Qiao J, Fan Y, Chang S, Ning Y, Yang Y, Liu M, Hao X, Gao J, Feng Y.
medRxiv 2025.07.09.25331189; doi: https://doi.org/10.1101/2025.07.09.25331189
Self-Report Alzheimer's Disease Statuses in UK Biobank Distort Downstream Analyses
Hu S, Zhu P, Gao S, Wu S, He Y, Liu F, Wang K, Liu G.
J Neurochem. 2025 Jul;169(7):e70151. doi: 10.1111/jnc.70151.
Sjögren’s syndrome is associated with a reduction in the surface area of the right caudal anterior cingulate gyrus
Ping Wang, Yunpeng Tai, Xiaofang Zhu, Xinyi Wan, An Sun, Jiajia Wang, Hui Cheng, Jingwei Hong, Yi Zhang , Xiaobing Wang
BMC Med 23, 415 (2025). https://doi.org/10.1186/s12916-025-04205-9
The host genes influencing Clostridioides difficile infection and the potential role of intestinal Lactobacillus acidophilus: a Mendelian randomization and animal model study
Yuxin Sun, Wenzhen Zhou, Senlin Ma, Qiuxin Lu, Yinuo Yuan, Yanchao Zheng, Yifan Yang, Kangshuai Zhou, Qingjiang Chen, Gonghao Sun, Zhaoming Shang, Junwei Qian, Xiaofei Jiang, Mingquan Chen
Front. Cell. Infect. Microbiol., 08 July 2025 Sec. Intestinal Microbiome Volume 15 - 2025 | https://doi.org/10.3389/fcimb.2025.1607476
Exploring the role of inflammation, immunity, and metabolism in colorectal cancer via mendelian randomization approach
Li Zhou, Mingjing Liao, Leilei Zhang, Tingting Peng, Chengyun Han, Qiang Zeng, Xuanrong Huan, Anya Dai, Zhongyan Gao, Jie Li, Jia Tang, Jie Chen, Yuan Li, Jiwang Zhang
Sci Rep 15, 24466 (2025). https://doi.org/10.1038/s41598-025-10318-1
The role of mitochondria-related proteins in inflammation and autoimmune diseases: a causal analysis using Mendelian randomization and colocalization
Hong Y.
Health Inf Sci Syst. 2025 Jul 8;13(1):42. doi: 10.1007/s13755-025-00358-2.
Bifidobacterium depletion promotes goiter via gut-thyroid axis: evidence from Mendelian randomization and experimental validation
Liao W, Jiang Y, Zhang J, Wu Y, Yu X, Chen S, Liu H, Xiu L, Zhong G.
Microbiol. 2025 Jul 7;16:1621167. doi: 10.3389/fmicb.2025.1621167.
A Causal Inference Study of Circulating Metabolites Mediating the Effect of Obesity-Related Indicators on the Incidence of Anxiety Disorders
Qin C, Gai W.
Brain Behav. 2025 Jul;15(7):e70653. doi: 10.1002/brb3.70653.
Differential association of platelet indices in NAFLD/NASH: a Mendelian randomized study
Huang H, Bai Y, Zhao Y, Sun X.
Eur J Gastroenterol Hepatol. 2025 Jul 7. doi: 10.1097/MEG.0000000000003029.
Recessive FANCM cancer syndrome with high cancer risks, chemotherapy toxicity, chromosome fragility and gonadal failure
Nynäs E, Sulkava S, Nurmi AK, Suvanto M, Aittomäki K; FinnGen; Nevanlinna H.
Genet Med. 2025 Jul 7:101521. doi: 10.1016/j.gim.2025.101521.
Systematic Druggable-Proteome-Wide Mendelian Randomization Identifies Potential Therapeutic Targets for Allergic Conjunctivitis
Chen J, Zhuo X, Ling Y, Zhu Y, Li Y, Shen X, Zhuo Y, Tan H, Li Z.
Transl Vis Sci Technol. 2025 Jul 1;14(7):6. doi: 10.1167/tvst.14.7.6.
Causal Effects of the Plasma Proteome on Vascular Dementia Risk: A Mendelian Randomization Study with Experimental Validation
Chen Y, Guo C, Liang X, Chi X, Zhang Z, Chang Z, Zhang Y.
Cell Mol Neurobiol. 2025 Jul 7;45(1):66. doi: 10.1007/s10571-025-01583-9.
Quantifying new threats to health and biomedical literature integrity from rapidly scaled publications and problematic research
Spick M, Onoja A, Harrison C, Stender S, Byrne J, Geifman N.
medRxiv 2025.07.07.25331008; doi: https://doi.org/10.1101/2025.07.07.25331008
Dual Functions and Therapeutic Potential of FZD6 in Biliary Atresia
Xinying Wang, Hongkun Lai, Ledong Tan, Ying Wen, Yanlu Tong, Lin Huang, Jiachi Liao, Yingyi Xu, Le Li, Ming Fu, Zefeng Lin
Dig Dis Sci (2025). https://doi.org/10.1007/s10620-025-09154-0
Multi-Omics Analysis and Validation of Cell Senescence-Related Genes Associated with Non-Alcoholic Fatty Liver Disease
Gong J, Qin Z, Xiao Y, Li J, Wang Q, Lei L, Li J.
J Inflamm Res. 2025 Jul 5;18:8821-8833. doi: 10.2147/JIR.S525168.
Cathepsin H increases the risk of diabetic retinopathy: evidence from Mendelian randomization and bioinformatic analysis
Xiudao Song, Jin Ma, Ting Zou, Rong Xin Lu, Wei Ji, Fei Huang, Meiqi Yin
Diabetol Metab Syndr 17, 255 (2025). https://doi.org/10.1186/s13098-025-01829-y
Causal association between cathepsins and asthma: a Mendelian randomization study
Qiu F, Shao W, Qin X, Xu R, Liu Y, Lu H.
Sci Rep. 2025 Jul 4;15(1):23984. doi: 10.1038/s41598-025-08457-6.
Multi-omics analysis identifies SNP-associated immune-related signatures by integrating Mendelian randomization and machine learning in hepatocellular carcinoma
Qingyan Kou, Zhichao Wu, Wenbin Zhao, Zhenyuan Liu, Shengxian Qiao, Qiang Mu, Xu Zhang
Sci Rep 15, 23930 (2025). https://doi.org/10.1038/s41598-025-09010-1
Migraine and cochlear disease: A 2-sample bidirectional Mendelian randomized study
Zhong C, Wang LH, Dong Y, Zhang HP, Ji L, Guo Y.
Medicine (Baltimore). 2025 Jul 4;104(27):e42418. doi: 10.1097/MD.0000000000042418.
Genome-Wide Association Study of COVID-19 Breakthrough Infections and Genetic Overlap with Other Diseases: A Study of the UK Biobank
Feng Y, Wong KC, Tsui WK, Zhang R, Xiang Y, So HC.
Int J Mol Sci. 2025 Jul 4;26(13):6441. doi: 10.3390/ijms26136441.
Genetic evidence for causal links between diet, gut microbiota, and hepatobiliary cancer: a Mendelian randomization study
Runze Huang, Xin Jin, Qinyu Liu, Xuanci Bai, Yibin Wu, Yixiu Wang, Xigan He, Ziting Jiang, Lu Wang, Weiping Zhu
AMB Expr 15, 100 (2025). https://doi.org/10.1186/s13568-025-01910-9
Genome-wide Association Study Identifies SORCS3 as a Novel Susceptibility Locus for Panic Disorder in the FinnGen Study
Naamanka J, Tasanko E, Trontti K, Novak B, Kinnunen V, Suvisaari J, Paunio T, Vaht M, Zhou W, Kurki M, Reinhart J, Boschet-Lange J, Pittig R, Pittig A, Misiewicz Z, Mattheisen M, Meier S, Binder EB, Metspalu A, Daly M, Turck CW, Erhardt-Lehmann A, Hartiala J, Hovatta I.
medRxiv 2025.07.03.25330813; doi: https://doi.org/10.1101/2025.07.03.25330813
PGS Browser: a public platform for personalized polygenic score interpretation
Kolosov N, Reeve MP, Della Briotta Parolo P, Kurki MI, Llorens V, FinnGen, Sipila TP, Herman A, Molotkov I, Aavikko M, Ripatti S, Palotie A, Daly MJ, Artomov M.
medRxiv 2025.07.03.25330851; doi: https://doi.org/10.1101/2025.07.03.25330851
Association between keloid and mental disorders: perspective from genetic evidence
Ying Zhan, Yanan Tong, Xiaodan Wu, Zhiguo Wang, Guoxu Zhang
Ann Gen Psychiatry 24, 42 (2025). https://doi.org/10.1186/s12991-025-00579-5
Identification of key genes as diagnostic biomarkers for IBD using bioinformatics and machine learning
Li T, Jing H, Gao X, Zhang T, Yao H, Zhang X, Zhang M.
J Transl Med. 2025 Jul 3;23(1):738. doi: 10.1186/s12967-025-06531-1.
Etiological basis for chronic pain genetic variation in brain and dorsal root ganglia cell types
Toikumo S, Parisien M, Leone MJ, Srinivasan C, Yu H, Arendt-Tranholm A, Franco-Enzástiga U, Hofstetter C, Curatolo M, Luo W, Pfenning AR, Seal RP, Kember RL, Price TJ, Diatchenko L, Waxman SG, Kranzler HR.
medRxiv 2025.07.03.25330832; doi: https://doi.org/10.1101/2025.07.03.25330832
Sedentary behaviors, physical activity, and risk of allergic rhinitis and asthma: evidence from cohort and Mendelian randomization studies
Xiaoyu Wang, Yaya Gao, Lin Lou, Wenjie Yang, Wei Xu, Yu Zhao, Jianjun Ren
BMC Pulm Med 25, 320 (2025). https://doi.org/10.1186/s12890-025-03779-7
Linking obstructive sleep apnea with pulmonary hypertension via pooled prevalence and causal association: A systematic review, meta-analysis and Mendelian randomization
Du D, Qin J, Hu X, Xu D, Gao L, Wu Y, Chen M, Chen Z, Luo F, Shen Y.
Heart Lung. 2025 Jul 2;74:82-89. doi: 10.1016/j.hrtlng.2025.06.009.
Real-world data and Mendelian randomization analysis in assessing adverse reactions of rilonacept
Lihong Liu, Zhenfei Chi, Zhe Zhang
Int J Clin Pharm 47, 1365–1374 (2025). https://doi.org/10.1007/s11096-025-01932-0
Detecting a potential causal relationship between plasma metabolites and myocardial infarction using bidirectional and two-step Mendelian randomization
Yang M, Wang M, Li J, Li M, Liu X, Li Y, Xue Y.
Sci Rep. 2025 Jul 2;15(1):23008. doi: 10.1038/s41598-025-04687-w.
Exploring the Causal Relationship Between Antidepressant Use and Lung Cancer Risk: A Mendelian Randomization Analysis
Yang C, Xu W.
Clin Respir J. 2025 Jul;19(7):e70102. doi: 10.1111/crj.70102.
Genetic susceptibility to cerebral palsy involves complement system-mediated neuronal development and plasticity pathway
Huang Kun, Qi Zhou, Hao Wu, Dejiang Yang, Chongyu Xiong, Xiaowei Zhang
Sci Rep 15, 23088 (2025). https://doi.org/10.1038/s41598-025-07178-0
Investigating the potential role of EIF2S2 in OSCC progression through comprehensive bioinformatics analysis and experimental validation
Zhiwen Shao, Tao Dong, Ke Yun, Zhaohui Wang, Yu Wen, Zongli Zhang, Tao Jia
Eur J Med Res 30, 562 (2025). https://doi.org/10.1186/s40001-025-02830-x