Tältä sivulta löydät kaikki FinnGen-aineistoa hyödyntäneet julkaisut ja preprint-artikkelit.
2025

Maaliskuu

Finding Potential Drug Targets for Pre-Eclampsia Using Mendelian Randomisation and Colocalisation Analysis
Xu Y, Pan Y, Wu C, Zhao T, Miao J, Ji X.
Am J Reprod Immunol. 2025 Mar;93(3):e70063. doi: 10.1111/aji.70063.
Genetic determinants of inflammatory cytokines and their causal relationship with inflammatory disorders of breast: a two-sample Mendelian randomization study
Wei H, Ge H, Qian Y, Li B.
Sci Rep. 2025 Mar 1;15(1):7300. doi: 10.1038/s41598-025-91723-4.
Genetically predicted plasma metabolites mediate the causal relationship between gut microbiota and osteosarcoma
Qin X, Fan Z, Qiao S, Li J, Lv J.
Sci Rep. 2025 Mar 1;15(1):7277. doi: 10.1038/s41598-025-91869-1.
The relationship between genetic prediction of 486 blood metabolites and the risk of COPD: mendelian randomization study
Zhang Y, Ma X, Wu F, Sun Y, Mou H, Liu X, Zhang W.
Sci Rep. 2025 Mar 1;15(1):7349. doi: 10.1038/s41598-025-92216-0.

Helmikuu

SFRP2 mediates Epstein-Barr virus and bladder cancer risk: a Mendelian randomization study and colocalization analysis
Li J, Yang B, Guo L, Huang W, Hu Q, Yan H, Du C, Tan R, Tang D.
Sci Rep. 2025 Feb 28;15(1):7118. doi: 10.1038/s41598-025-91594-9.
Causal Association Between Cholesterol-Lowering Drugs and Diabetic Microvascular Complications: A Drug-Target Mendelian Randomization Study
Yang B, Yao B, Zou Q, Li S, Yang S, Yang M.
J Diabetes Res. 2025 Feb 28;2025:3661739. doi: 10.1155/jdr/3661739.
Gene discovery and pleiotropic architecture of Chronic Pain in a Genome-wide Association Study of >1.2 million Individuals
Toikumo S, Davis C, Jinwala Z, Khan Y, Jennings M, Davis L, Sanchez-Roige S, Kember RL, Kranzler HR.
medRxiv 2025.02.28.25323112; doi: https://doi.org/10.1101/2025.02.28.25323112
Genetic insights into cardiac conduction disorders from genome-wide association studies
Li B, Xu H, Wu L.
Hum Genomics. 2025 Feb 28;19(1):20. doi: 10.1186/s40246-025-00732-x.
Blood metabolites reflect the effect of gut microbiota on differentiated thyroid cancer: a Mendelian randomization analysis
Zhang H, Li Y, Li L.
BMC Cancer. 2025 Feb 28;25(1):368. doi: 10.1186/s12885-025-13598-y.
Causal relationships between allergic diseases and significant declines in lung function: a multivariable Mendelian randomization study
Lin J, Zhao X, Lu S.
J Asthma. 2025 Feb 27:1-8. doi: 10.1080/02770903.2025.2472359.
Novel drug targets for delirium based on genetic causality
Zhu S, Ding X, Bo J, Xia T, Gu X.
J Affect Disord. 2025 Feb 27;378:128-137. doi: 10.1016/j.jad.2025.02.095.
Relationship of obesity, body fat, benign adrenal tumors and the mediating mechanism: a two-step mendelian randomization study
Wang Q, Lv D, Wen J, Zhou H, Jia M, Li J, Du H, Shuang W.
BMC Cancer. 2025 Feb 27;25(1):360. doi: 10.1186/s12885-025-13774-0.
Activation of FGFR genes by genetic and epigenetic alterations in uterine leiomyomas
Jokinen V, Taira A, Kolterud Å, Ahlgren I, Palin K, Katainen R, Räisänen M, Kaasinen E, Ilves S, Raitila A, Kopp Kallner H, Siili E, Bützow R, Heikinheimo O, Pasanen A, Karhu A, Välimäki N, Aaltonen LA.
BJC Rep. 2025 Feb 27;3(1):9. doi: 10.1038/s44276-025-00127-4.
Bone mineral density and sex hormone binding globulin as potential mediators of the causal effect of urolithiasis on osteoporosis risk: a Mendelian randomization
Guo J, Chen X, Yi X, Dou Y, Xiong Y, Zhao T.
Endocrinol (Lausanne). 2025 Feb 26;16:1460682. doi: 10.3389/fendo.2025.1460682.
Free triiodothyronine and risk of gestational diabetes mellitus: an observational study and Mendelian randomization analysis
Li Y, Yang S, Huang Z, Zhang Y, Guan H, Fan J.
Nutr Metab (Lond). 2025 Feb 26;22(1):17. doi: 10.1186/s12986-025-00905-4.
Causal association between inflammatory proteins, inflammatory cells and Cauda Equina Syndrome: A two-sample Mendelian randomization
Xing J, Wang J, Han L, Wang Y, Sun X, Shi J, Kong Q, Sun K, Zhang B.
World Neurosurg. 2025 Feb 26:123826. doi: 10.1016/j.wneu.2025.123826.
Causal Relationship between Branched-Chain Amino Acids and Inflammatory Bowel Disease: A Bidirectional and Multivariable Mendelian Randomization Study
Zhou J, Zhu F, Sun L.
Br J Hosp Med (Lond). 2025 Feb 25;86(2):1-17. doi: 10.12968/hmed.2024.0722.
Causal relationship between osteoporosis, bone mineral density, and osteonecrosis: a bidirectional two-sample Mendelian randomization study
Zhang C, Yu H, Miao Y, Wei B.
J Transl Med. 2025 Feb 25;23(1):226. doi: 10.1186/s12967-024-06030-9.
Increased risk of chronic diseases and multimorbidity in middle-aged and elderly individuals with early vision, hearing, or dual sensory impairments: insights from prospective cohort studies and Mendelian randomization analysis
Wang Y, Cheng F, Hou N, Tan Y, Zhang S, Hou Y, Guo W, Peng J, Li W, Wu J.
BMC Med. 2025 Feb 25;23(1):118. doi: 10.1186/s12916-025-03857-x.
Autoimmune disease and risk of lymphoma: analysis from real-world data and Mendelian randomization study
Zhan L, Chen S, Liu Y, Lu T, Yu Z, Wang X, Zhou X.
BMC Cancer. 2025 Feb 25;25(1):351. doi: 10.1186/s12885-025-13754-4.
Cross-ancestry genome-wide association study and systems-level integrative analyses implicate new risk genes and therapeutic targets for depression
Li Y, Dang X, Chen R, Teng Z, Wang J, Li S, Yue Y, Mitchell BL, Zeng Y, Yao YG, Li M, Liu Z, Yuan Y, Li T, Zhang Z, Luo XJ.
Nat Hum Behav. 2025 Feb 24. doi: 10.1038/s41562-024-02073-6.
Plasma proteins and herpes simplex virus infection: a proteome-wide Mendelian randomization study
Fu C, Xu W, Xu X, Zhao F, Zheng C, Yin Z.
Virus Genes. 2025 Feb 24. doi: 10.1007/s11262-025-02145-3.
Spleen volume in relation to ulcerative colitis and Crohn's disease: a Mendelian randomization study
Su Q, Li J, Lu Y, Liang J, Huang S, Wu M, He Y, An Z, Ding J, Zhang Z.
Sci Rep. 2025 Feb 24;15(1):6588. doi: 10.1038/s41598-025-90104-1.
Two-sample Mendelian randomization analysis of the causal relationship between lipid metabolism/fatty acid metabolism and pre-eclampsia
Yang D, Chen J, Wang X, Zhuang L, Feng H, Liao X, Mo T.
Ginekol Pol. 2025 Mar 12. doi: 10.5603/gpl.101256.
Proteome-wide Mendelian randomization identifies causal plasma proteins in prostate cancer development
Wu J, Yang Z, Ding J, Hao S, Chen H, Jin K, Zhang C, Zheng X.
Hum Genomics. 2025 Feb 24;19(1):17. doi: 10.1186/s40246-025-00724-x.
EPIraction - an atlas of candidate enhancer-gene interactions in human tissues and cell lines
Nurtdinov RN, Guigó R.
bioRxiv [Preprint]. 2025 Feb 23:2025.02.18.638885. doi: 10.1101/2025.02.18.638885.
Identifying genetic overlaps in obesity and metabolic disorders unlocking unique and shared mechanistic insights
Fu L, Han X, Wang Y, Hu YQ.
Free Radic Biol Med. 2025 Feb 23;231:80-93. doi: 10.1016/j.freeradbiomed.2025.02.033.
A large-scale genome-wide association study on female genital tract polyps highlights role of DNA repair, cell proliferation, and cell growth
Pathare ADS, Džigurski J, Pujol-Gualdo N, Rukins V, Peters M; Estonian Biobank Research Team; Mägi R, Salumets A, Saare M, Laisk T.
Hum Reprod. 2025 Feb 22:deaf025. doi: 10.1093/humrep/deaf025.
A large-scale genome-wide association study on female genital tract polyps highlights role of DNA repair, cell proliferation, and cell growth
Pathare ADS, Džigurski J, Pujol-Gualdo N, Rukins V, Peters M; Estonian Biobank Research Team; Mägi R, Salumets A, Saare M, Laisk T.
Hum Reprod. 2025 Apr 1;40(4):750-763. doi: 10.1093/humrep/deaf025.
Based on the resting-state functional magnetic resonance imaging reveals the causal relationship between the brain function network and the risk of tinnitus: a bidirectional Mendelian randomization analysis
Liu Y, Li C, Yao L, Tan Y, Shi L, Chen P.
Brain Imaging Behav. 2025 Feb 22. doi: 10.1007/s11682-025-00986-y.
Genetically predicted circulating immune cells and cytokines reveal the causal role of immune factors on female infertility: a two-sample mendelian randomization study
Dong KX, Mo JH, Yan J, Cheng Y, Chen HX, Xu NX, Dou ZY, Zhu H, Zhu L, Huang HF.
BMC Pregnancy Childbirth. 2025 Feb 22;25(1):195. doi: 10.1186/s12884-025-07318-4.
The 2-Step Mendelian Randomisation Study Assesses Genetic Causality and Potential Mediators of Periodontal Disease and Atrial Fibrillation
Zhang X, Lian C, Shi S, Li J, Wang L, Guo Z, Liu N, Wang H, Hu Y, Du B.
Int Dent J. 2025 Feb 22:S0020-6539(25)00003-6. doi: 10.1016/j.identj.2024.12.029.
Gut microbiota and male fertility: A two-sample Mendelian randomization study
Wang ZH, Kang YF.
Medicine (Baltimore). 2025 Feb 21;104(8):e41542. doi: 10.1097/MD.0000000000041542.
Mendelian randomization analysis revealed a gut microbiota-eye axis in acute anterior uveitis
Mi Y, Chen L, Liao N, Wan M.
Eye (Lond). 2025 Feb 21. doi: 10.1038/s41433-025-03715-3.
Moderate and severe depression increase the incidence of cholelithiasis: Results from Mendelian randomization study and the NHANES 2017-March 2020
Ma M, Xie K, Jin T, Xu F.
Soc Psychiatry Psychiatr Epidemiol. 2025 Feb 21. doi: 10.1007/s00127-025-02843-1.
Circulating inflammatory cytokines and risk of aortic stenosis: A Mendelian randomization analysis
Qiu X, Wu J, Chen Z, Zhang Y, Cao L, Wang N, Teng J, Su C, Cheng C, Wang F, Chen W.
Cytokine. 2025 Feb 21;189:156887. doi: 10.1016/j.cyto.2025.156887.
The causal relationship between hallux valgus and endogenous pathogenic factors: A 2-sample Mendelian randomization
Xie YL, Liang JY, Du GF, Lu HJ, Luo WJ, Wu JH, Sheng ZH.
Medicine (Baltimore). 2025 Feb 21;104(8):e41647. doi: 10.1097/MD.0000000000041647.
Triangular Causality Among Pulmonary Hypertension, Sleep Disorders, and Brain Structure at the Genetic Level: A Mendelian Randomization Study Focused on the Lung-Brain Axis
Zhang C, Su X, Zhang Y, He P, Kong X, Zhang Z, Wei Y, Shi Y.
Nat Sci Sleep. 2025 Feb 21;17:343-356. doi: 10.2147/NSS.S495071.
Genetic evidence identifies a causal relationship between EBV infection and multiple myeloma risk
Li J, Tan R, Yang B, Du C, Tian J, Yang Z, Tang D.
Sci Rep. 2025 Feb 21;15(1):6357. doi: 10.1038/s41598-025-90479-1.
Identification of potential diagnostic biomarkers and drug targets for endometriosis from a genetic perspective: a mendelian randomization study
Zhu Y, Cheng F, Zhu L, Yang X, He M, Wang W.
Gynecol Obstet Invest. 2025 Feb 20:1-22. doi: 10.1159/000543707.
Mendelian randomization analyses uncover causal relationships between brain structural connectome and risk of psychiatric disorders
Xiao K, Chang X, Ye C, Zhang Z, Ma T, Su J.
medRxiv 2025.02.20.25322606; doi: https://doi.org/10.1101/2025.02.20.25322606
A multistage, multitask transformer-based framework for multi-disease diagnosis and prediction using personal proteomes
Li H, Li Y, Liu Y, Cooper-Knock J, Gao P, Shen X, Chen S, Xing X, Zhang S.
medRxiv 2025.02.19.25322536; doi: https://doi.org/10.1101/2025.02.19.25322536
Major depressive disorder and the development of cerebral small vessel disease: A Mendelian randomization study
Lu T, Luo L, Yang J, Li Y, Chen D, Sun H, Liao H, Zhao W, Ren Z, Xu Y, Yu S, Cheng X, Sun J.
J Affect Disord. 2025 May 15;377:68-76. doi: 10.1016/j.jad.2025.02.067.
Dissecting the genetic etiology of intestinal obstruction: mendelian randomization identifies potential therapeutic targets
Haodong Z, Baoping C, Jiongjiong C, Jia C, Hui L, Yu W, Bocheng D.
medRxiv 2025.02.19.25322532; doi: https://doi.org/10.1101/2025.02.19.25322532
Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases
Mitchell J, Camacho N, Shea P, Stopsack KH, Joseph V, Burren OS, Dhindsa RS, Nag A, Berchuck JE, O'Neill A, Abbasi A, Zoghbi AW, Alegre-Díaz J, Kuri-Morales P, Berumen J, Tapia-Conyer R, Emberson J, Torres JM, Collins R, Wang Q, Goldstein D, Matakidou A, Haefliger C, Anderson-Dring L, March R, Jobanputra V, Dougherty B, Carss K, Petrovski S, Kantoff PW, Offit K, Mucci LA, Pomerantz M, Fabre MA.
Nat Commun. 2025 Feb 19;16(1):1779. doi: 10.1038/s41467-025-56944-1.
Leukemia and risk of stroke: a Mendelian randomization analysis
Yi X, Zhu J, Zhang X, Huang N, Cheng Y.
BMC Neurol. 2025 Feb 19;25(1):68. doi: 10.1186/s12883-025-04079-7.
Exploring the Diet-diverticular Disease Link: Insights from a Comprehensive Mendelian Randomization Study
Zhou J, Xu Y, Wang H, Wang K, Chen C.
Curr Med Chem. 2025 Feb 18. doi: 10.2174/0109298673342480250203111209.
Unveiling the Connection Between Micronutrients and Autoimmune Thyroiditis: Are They True Friends?
Yu Y, Tong K, Deng J, Wu J, Yu R, Xiang Q.
Biol Trace Elem Res. 2025 Feb 18. doi: 10.1007/s12011-025-04548-7.
Exploring the causal influence of 731 immune cells on 4 different glaucoma subtypes using a two-sample mendelian randomization method
Han X, Wang J, Su X, Guo X, Ye H.
Sci Rep. 2025 Feb 18;15(1):5987. doi: 10.1038/s41598-025-90545-8.
Associations Between Gut Microbiota and Diabetic Nephropathy: A Mendelian Randomization Study
Xiong Y, Zhu X, Xu H, Zheng Z, Luo Q.
Aging Med (Milton). 2025 Feb 18;8(1):e70009. doi: 10.1002/agm2.70009.