Tältä sivulta löydät kaikki FinnGen-aineistoa hyödyntäneet julkaisut ja preprint-artikkelit.
2022

Elokuu

Screening for potential undiagnosed Gaucher disease patients: Utilisation of the Gaucher earlier diagnosis consensus point-scoring system (GED-C PSS) in conjunction with electronic health record data, tissue specimens, and small nucleotide polymorphism (SNP) genotype data available in Finnish biobanks
Pehrsson M, Heikkinen H, Wartiovaara-Kautto U, Mäntylahti S, Bäckström P, Lassenius MI, Uusi-Rauva K, Carpén O, Elomaa K.
Mol Genet Metab Rep. 2022 Aug 27;33:100911. doi: 10.1016/j.ymgmr.2022.100911.
Noncausal effects of genetic predicted depression and colorectal cancer risk: A Mendelian randomization study
Wu E, Ni JT, Xie T, Tao L.
Medicine (Baltimore). 2022 Aug 26;101(34):e30177. doi: 10.1097/MD.0000000000030177.
Large registry-based analysis of genetic predisposition to tuberculosis identifies genetic risk factors at HLA
Tervi A, Junna N, Broberg M, Jones SE, FinnGen, Strausz S, Kreivi H-R, Heckman CA, Ollila HM.
Hum Mol Genet. 2022 Aug 26:ddac212. doi: 10.1093/hmg/ddac212.
Coffee and caffeine consumption and risk of renal cell carcinoma: A Mendelian randomization study
Li BH, Yan SY, Li XH, Huang Q, Luo LS, Wang YY, Huang J, Jin YH, Wang YB.
Front Nutr. 2022 Aug 22;9:898279. doi: 10.3389/fnut.2022.898279.
Meta-analysis fine-mapping is often miscalibrated at single-variant resolution
Kanai M, Elzur R, Zhou W, Global Biobank Meta-analysis Initiative, Daly MJ, Finucane HK.
Cell Genomics doi: 10.1016/j.xgen.2022.100210
Circulating adipokine levels and preeclampsia: A bidirectional Mendelian randomization study
Chen X, Liu Z, Cui J, Chen X, Xiong J, Zhou W.
Front Genet. 2022 Aug 22;13:935757. doi: 10.3389/fgene.2022.935757.
Genetically predicted cortisol levels and risk of venous thromboembolism
Allara E, Lee WH, Burgess S; INVENT consortium, Larsson SC.
PLoS One. 2022 Aug 19;17(8):e0272807. doi: 10.1371/journal.pone.0272807.
Identifying and correcting for misspecifications in GWAS summary statistics and polygenic scores
Privé F, Arbel J, Aschard H, Vilhjálmsson BJ.
HGG Adv. 2022 Aug 18;3(4):100136. doi: 10.1016/j.xhgg.2022.100136.
Protective Effects of Circulating TIMP3 on Coronary Artery Disease and Myocardial Infarction: A Mendelian Randomization Study
Chen H, Chen S, Ye H, Guo X.
J Cardiovasc Dev Dis. 2022 Aug 18;9(8):277. doi: 10.3390/jcdd9080277.
Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis
Ruotsalainen SE, Surakka I, Mars N, Karjalainen J, Kurki M, Kanai M, Krebs K, Graham S, Mishra PP, Mishra BH, Sinisalo J, Palta P, Lehtimäki T, Raitakari O; Estonian Biobank Research Team, Milani L; Biobank Japan Project, Okada Y; FinnGen, Palotie A, Widen E, Daly MJ, Ripatti S.
Commun Biol. 2022 Aug 17;5(1):802. doi: 10.1038/s42003-022-03552-0.
Assessment of the Causal Effect of IgG N-Glycosylation Level on Risk of Dementia: A 2-Sample Mendelian Randomization Study
Zhang X, Cong R, Geng T, Zhang J, Liu D, Tian Q, Meng X, Song M, Wu L, Zheng D, Wang W, Wang B, Wang Y.
J Alzheimers Dis. 2022;88(4):1435-1441. doi: 10.3233/JAD-220074.
Plasma Phospholipid Fatty Acids and Risk of Venous Thromboembolism: Mendelian Randomization Investigation
Yuan S, Li X, Morange PE, Bruzelius M, Larsson SC, On Behalf Of The Invent Consortium.
Nutrients. 2022 Aug 16;14(16):3354. doi: 10.3390/nu14163354.
Alleviating insomnia should decrease the risk of irritable bowel syndrome: Evidence from Mendelian randomization
Bao W, Qi L, Bao Y, Wang S, Li W.
Front Pharmacol. 2022 Aug 16;13:900788. doi: 10.3389/fphar.2022.900788.
A Mendelian randomization-based exploration of red blood cell distribution width and mean corpuscular volume with risk of hemorrhagic strokes
Liu J, Chou EL, Lau KK, Woo PYM, Wan TK, Huang R, Chan KHK.
HGG Adv. 2022 Aug 10;3(4):100135. doi: 10.1016/j.xhgg.2022.100135.
Genetic insights into therapeutic targets for aortic aneurysms: A Mendelian randomization study
Chen Y, Xu X, Wang L, Li K, Sun Y, Xiao L, Dai J, Huang M, Wang Y, Wang DW.
EBioMedicine. 2022 Aug 8;83:104199. doi: 10.1016/j.ebiom.2022.104199.
Association of cardiovascular risk factors and lifestyle behaviors with aortic aneurysm: A Mendelian randomization study
Zhou J, Lin J, Zheng Y.
Front Genet. 2022 Aug 8;13:925874. doi: 10.3389/fgene.2022.925874.
Investigating Causal Associations of Diet-Derived Circulating Antioxidants with the Risk of Digestive System Cancers: A Mendelian Randomization Study
Zhang X, Zhao H, Man J, Yin X, Zhang T, Yang X, Lu M.
Nutrients. 2022 Aug 8;14(15):3237. doi: 10.3390/nu14153237.
Circulating vitamin C and digestive system cancers: Mendelian randomization study
Larsson SC, Mason AM, Vithayathil M, Carter P, Kar S, Zheng JS, Burgess S.
Clin Nutr. 2022 Aug 7;41(9):2031-2035. doi: 10.1016/j.clnu.2022.07.040.
A first update on mapping the human genetic architecture of COVID-19
COVID-19 Host Genetics Initiative.
Nature. 2022 Aug;608(7921):E1-E10. doi: 10.1038/s41586-022-04826-7.
A putative causality of vitamin D in common diseases: A mendelian randomization study
Liu H, Shen X, Yu T, Wang Y, Cai S, Jiang X, Cai X.
Front Nutr. 2022 Aug 2;9:938356. doi: 10.3389/fnut.2022.938356.
Integrated analyses of growth differentiation factor-15 concentration and cardiometabolic diseases in humans
Lemmelä S, Wigmore EM, Benner C, Havulinna AS, Ong RMY, Kempf T, Wollert KC, Blankenberg S, Zeller T, Peters JE, Salomaa V, Fritsch M, March R, Palotie A, Daly M, Butterworth AS, Kinnunen M, Paul DS, Matakidou A.
Elife. 2022 Aug 2;11:e76272. doi: 10.7554/eLife.76272.

Heinäkuu

Genetic liability to sedentary behavior in relation to myocardial infarction and heart failure: A mendelian randomization study
Yang F, Huangfu N, Chen S, Hu T, Qu Z, Wang K, Cui H, Xie X.
Nutr Metab Cardiovasc Dis. 2022 Nov;32(11):2621-2629. doi: 10.1016/j.numecd.2022.07.005.
The causal association between smoking, alcohol consumption and risk of bladder cancer: A univariable and multivariable Mendelian randomization study
Xiong J, Yang L, Deng YQ, Yan SY, Gu JM, Li BH, Zi H, Ming DJ, Zeng XT, Wang YB.
Int J Cancer. 2022 Jul 29. doi: 10.1002/ijc.34228.
Causal association of diet-derived circulating antioxidants with the risk of rheumatoid arthritis: A Mendelian randomization study
Zhou X, Mi J, Liu Z.
Semin Arthritis Rheum. 2022 Jul 28;56:152079. doi: 10.1016/j.semarthrit.2022.152079.
A Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Susceptibility Genes for Juvenile Idiopathic Arthritis in Asia and Europe
Xu J, Ma J, Zeng Y, Si H, Wu Y, Zhang S, Shen B.
Front Immunol. 2022 Jul 28;13:941398. doi: 10.3389/fimmu.2022.941398.
Genetic liability to asthma and risk of cardiovascular diseases: A Mendelian randomization study
Chen H, Chen W, Zheng L.
Front Genet. 2022 Jul 26;13:879468. doi: 10.3389/fgene.2022.879468.
Association of Nap Frequency With Hypertension or Ischemic Stroke Supported by Prospective Cohort Data and Mendelian Randomization in Predominantly Middle-Aged European Subjects
Yang MJ, Zhang Z, Wang YJ, Li JC, Guo QL, Chen X, Wang E.
Hypertension. 2022 Sep;79(9):1962-1970. doi: 10.1161/HYPERTENSIONAHA.122.19120.
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci
Deak JD, Zhou H, Galimberti M, Levey DF, Wendt FR, Sanchez-Roige S, Hatoum AS, Johnson EC, Nunez YZ, Demontis D, Børglum AD, Rajagopal VM, Jennings MV, Kember RL, Justice AC, Edenberg HJ, Agrawal A, Polimanti R, Kranzler HR, Gelernter J.
Mol Psychiatry. 2022 Jul 25. doi: 10.1038/s41380-022-01709-1.
Assessment of the bi-directional relationship between blood mitochondrial DNA copy number and type 2 diabetes mellitus: a multivariable-adjusted regression and Mendelian randomisation study
Wang W, Luo J, Willems van Dijk K, Hägg S, Grassmann F, T Hart LM, van Heemst D, Noordam R.
Diabetologia. 2022 Jul 22. doi: 10.1007/s00125-022-05759-6.
A Mendelian Randomization Study to Assess the Genetic Liability of Gastroesophageal Reflux Disease for Cardiovascular Diseases and Risk Factors
Sun X, Chen L, Zheng L.
Hum Mol Genet. 2022 Jul 21:ddac162. doi: 10.1093/hmg/ddac162.
Shared genetic susceptibility between trigger finger and carpal tunnel syndrome: a genome-wide association study
Patel B, Kleeman SO, Neavin D, Powell J, Baskozos G, Ng M, Ahmed WU, Bennett DL, Schmid AB, Furniss D, Wiberg A.
Lancet Rheumatol. 2022 Aug;4(8):e556-e565. doi: 10.1016/S2665-9913(22)00180-1.
Multinational Genome-Wide Association Study and Functional Genomics Analysis Implicates Decreased SIRT3 Expression Underlying Intracranial Aneurysm Risk
Hale AT, He J, Jones J.
Neurosurgery. 2022 Jul 19. doi: 10.1227/neu.0000000000002082.
Association between dried fruit intake and pan-cancers incidence risk: A two-sample Mendelian randomization study
Jin C, Li R, Deng T, Lin Z, Li H, Yang Y, Su Q, Wang J, Yang Y, Wang J, Chen G, Wang Y.
Front Nutr. 2022 Jul 18;9:899137. doi: 10.3389/fnut.2022.899137.
The impact of fatty acids biosynthesis on the risk of cardiovascular diseases in Europeans and East Asians: a Mendelian randomization study
Borges MC, Haycock P, Zheng J, Hemani G, Howe LJ, Schmidt AF, Staley JR, Lumbers RT, Henry A, Lemaitre RN, Gaunt TR, Holmes MV, Davey Smith G, Hingorani AD, Lawlor DA.
Hum Mol Genet. 2022 Nov 28;31(23):4034-4054. doi: 10.1093/hmg/ddac153.

Kesäkuu

The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness
Reay WR, Geaghan MP; 23andMe Research Team; Cairns MJ.
Nat Commun. 2022 Jun 29;13(1):3756. doi: 10.1038/s41467-022-31473-3.
The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness
Reay WR, Geaghan MP; 23andMe Research Team, Cairns MJ.
Nat Commun. 2022 Jun 29;13(1):3756. doi: 10.1038/s41467-022-31473-3.
Alcohol consumption and smoking in relation to psoriasis: a Mendelian randomization study
Wei J, Zhu J, Xu H, Zhou D, Elder JT, Tsoi LC, Patrick MT, Li Y.
Br J Dermatol. 2022 Jun 28. doi: 10.1111/bjd.21718.
Causal associations between sleep traits and four cardiac diseases: a Mendelian randomization study
Yang Y, Fan J, Shi X, Wang Y, Yang C, Lian J, Wang N, Zhao C, Zhao Y, Jia X.
ESC Heart Fail. 2022 Jun 28. doi: 10.1002/ehf2.14016.
Maternal Testosterone and Offspring Birth Weight: A Mendelian Randomization Study
Zheng BK, Sun XY, Xian J, Niu PP.
J Clin Endocrinol Metab. 2022 Aug 18;107(9):2530-2538. doi: 10.1210/clinem/dgac389.
Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity
Zheng J, Zhang Y, Zhao H, Liu Y, Baird D, Karim MA, Ghoussaini M, Schwartzentruber J, Dunham I, Elsworth B, Roberts K, Compton H, Miller-Molloy F, Liu X, Wang L, Zhang H, Smith GD, Gaunt TR.
EBioMedicine. 2022 Jul;81:104112. doi: 10.1016/j.ebiom.2022.104112.
Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse
Pujol-Gualdo N, Läll K, Lepamets M; Estonian Biobank Research Team, Rossi HR, Arffman RK, Piltonen TT, Mägi R, Laisk T.
Nat Commun. 2022 Jun 23;13(1):3584. doi: 10.1038/s41467-022-31188-5.
Causal Association between Whole Body Water Mass and Sleep Apnea: A Mendelian Randomization Study
Zhou T, Xie J, Wang X, Chen G, Wang Y, Liang T, Kuang X, Liao W, Song L, Zhang X.
Ann Am Thorac Soc. 2022 Jun 21. doi: 10.1513/AnnalsATS.202112-1331OC.
A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood
Kurniansyah N, Goodman MO, Kelly TN, Elfassy T, Wiggins KL, Bis JC, Guo X, Palmas W, Taylor KD, Lin HJ, Haessler J, Gao Y, Shimbo D, Smith JA, Yu B, Feofanova EV, Smit RAJ, Wang Z, Hwang SJ, Liu S, Wassertheil-Smoller S, Manson JE, Lloyd-Jones DM, Rich SS, Loos RJF, Redline S, Correa A, Kooperberg C, Fornage M, Kaplan RC, Psaty BM, Rotter JI, Arnett DK, Morrison AC, Franceschini N, Levy D; NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, Sofer T.
Nat Commun. 2022 Jun 21;13(1):3549. doi: 10.1038/s41467-022-31080-2.
The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyses
Martens LG, Luo J, Wermer MJH, Willems van Dijk K, Hägg S, Grassmann F, Noordam R, van Heemst D.
Atherosclerosis. 2022 Aug;354:1-7. doi: 10.1016/j.atherosclerosis.2022.06.1012.
Rare germline deleterious variants increase susceptibility for lung cancer
Sang J, Zhang T, Kim J, Li M, Pesatori AC, Consonni D, Song L, Liu J, Zhao W, Hoang PH, Campbell DS, Feng J, D'Arcy ME, Synnott N, Chen Y, Wu Z, Zhu B, Yang XR, Brown KM, Choi J, Shi J, Landi MT.
Hum Mol Genet. 2022 Jun 18:ddac123. doi: 10.1093/hmg/ddac123.
Genome-Wide 3'-UTR Single Nucleotide Polymorphism Association Study Identifies Significant Prostate Cancer Risk-Associated Functional Loci at 8p21.2 in Chinese Population
Zhang N, Huang D, Jiang G, Chen S, Ruan X, Chen H, Huang J, Liu A, Zhang W, Lin X, Wu Y, Zhang Q, Li J, Tsu JH, Wei GH, Na R.
Adv Sci (Weinh). 2022 Aug;9(23):e2201420. doi: 10.1002/advs.202201420.
Self-Reported Walking Pace and Risk of Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study
Chen L, Sun X, He Y, Zheng L.
Front Genet. 2022 Jun 16;13:871302. doi: 10.3389/fgene.2022.871302.
Identification of blood metabolites linked to the risk of cholelithiasis: a comprehensive Mendelian randomization study
Mi J, Jiang L, Liu Z, Wu X, Zhao N, Wang Y, Bai X.
Hepatol Int. 2022 Jun 15. doi: 10.1007/s12072-022-10360-5.
Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations
Wang K, Shi X, Zhu Z, Hao X, Chen L, Cheng S, Foo RSY, Wang C.
Genome Med. 2022 Jun 14;14(1):63. doi: 10.1186/s13073-022-01067-1.
GDF-15 as a Therapeutic Target of Diabetic Complications Increases the Risk of Gallstone Disease: Mendelian Randomization and Polygenic Risk Score Analysis
Yu L, Zhou Y, Wang L, Zhou X, Sun J, Xiao J, Xu X, Larsson SC, Yuan S, Li X.
Front Genet. 2022 Jun 13;13:814457. doi: 10.3389/fgene.2022.814457.