Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulation

Arushi Varshney, Nandini Manickam, Peter Orchard, Adelaide Tovar, Christa Ventresca, Zhenhao Zhang, Fan Feng, Joseph Mears, Michael R. Erdos, Narisu Narisu, Kirsten Nishino, Vivek Rai, Heather M. Stringham, Anne U. Jackson, Tricia Tamsen, Chao Gao, Mao Yang, Olivia I. Koues, Joshua D. Welch, Charles F. Burant, L. Keoki Williams, Chris Jenkinson, Ralph A. DeFronzo, Luke Norton, Jouko Saramies, Timo A. Lakka, Markku Laakso, Jaakko Tuomilehto, Karen L. Mohlke, Jacob O. Kitzman, Heikki A. Koistinen, Jie Liu, Michael Boehnke, Francis S. Collins, Laura J. Scott & Stephen C. J. Parker
Nat Genet 58, 2804–2818 (2026). https://doi.org/10.1038/s41588-026-02786-6
Article
Oct 28, 2026
Consortium publication
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