Below you will find all the published and preprint scientific papers using FinnGen data.

2025

August

Identifying potential drug targets for postoperative abdominal wall hernia using Mendelian randomization: a multi-omics study
Sun C, Liu G, Liu T, Gong H.
Sci Rep . 2025 Aug 25;15(1):31316. doi: 10.1038/s41598-025-16101-6.
DNA methylation regulates TREM1expression to modulate immune responses and drive progression in colorectal neuroendocrine neoplasm as a potential therapeutic target
Huimin Guo, Guiwen Zheng, Jia Li, Shuzhan Yao, Qiang Jia, Jian Tan, Zhaowei Meng
Discov Onc 16, 1624 (2025). https://doi.org/10.1007/s12672-025-03468-1
Multi-omics integration reveals CYTL1 and H6PD as key regulators of tumor metabolism in mesothelioma
Jiao Ma, Huilin Zhang, Luanxue Yu, Yunqing Guo, Jiawei Ming, Zhenying Guo
Genes Genom 47, 1049–1063 (2025). https://doi.org/10.1007/s13258-025-01667-2
Scalable biological-cognitive profiling for Alzheimer’s disease in the population
Karin Lohi, Aino Aaltonen, Sanna-Kaisa Herukka, Tarja Kokkola, Sari Kärkkäinen, Mia Urjansson, FinnGen, Aarno Palotie, Heiko Runz, Jaakko Kaprio, Valtteri Julkunen, Toni Saari, Eero Vuoksimaa
medRxiv 2025.08.20.25333966; doi: https://doi.org/10.1101/2025.08.20.25333966
Age-specific childhood obesity and adult cholelithiasis: association and shared transcriptomic bases
Liu L, Zhang L, Liao Y, Jin X, Chen Y, Yang T, Li X, Cao Y, Yu C, Xiao C, Liu Z, Tong Y.
Int J Obes (Lond) . 2025 Aug 22. doi: 10.1038/s41366-025-01877-4.
Will diabetes mellitus induce aplastic anemia by immune factors?: A two-sample and mediation Mendelian randomization study
Zhong C, Duan C, Zeng Y, Guo T.
Medicine (Baltimore) . 2025 Aug 22;104(34):e44033. doi: 10.1097/MD.0000000000044033.
Effect of Glucagon-Like Peptide 1 Receptor Agonists on Obstructive Sleep Apnea
Qian BB, Huang YJ, Yan CF, Feng SY, She DM.
Obes Sci Pract. 2025 Aug 22;11(4):e70090. doi: 10.1002/osp4.70090. eCollection 2025 Aug.
Gut microbiota and diabetic neuropathy/peripheral artery disease: A two-sample Mendelian randomization study investigating risk factors for diabetic foot ulcers
Tang G, Wang Y, Wu J, Zhu R, Guo H, Zhang Y, Chen Z.
Medicine (Baltimore) . 2025 Aug 22;104(34):e43637. doi: 10.1097/MD.0000000000043637
A Mendelian randomization study of the associations between depression, anxiety and clinical conditions including thyroid nodules, flatulence, and irregular menstruation
Bi Z, Wang L, Li J, Jing J, Fang Z.
Medicine (Baltimore) . 2025 Aug 22;104(34):e44041. doi: 10.1097/MD.0000000000044041.
Constipation and Parkinson disease: A 2-sample bidirectional Mendelian randomization analysis
Li H, Su G, Kang W, Huang W, Liu A, Zhang M.
Medicine (Baltimore) . 2025 Aug 22;104(34):e43240. doi: 10.1097/MD.0000000000043240.
Integrated multi-omics reveals the ITGB2-IL2RB-NK axis in promoting papillary thyroid carcinoma progression and immune microenvironment crosstalk
Jianxiong Xu, Chen Gao
Researchsquare, 21 August 2025, doi:10.21203/rs.3.rs-7218110/v1
Elucidating the associations and molecular mechanisms of perfluoroalkyl substances exposure with type 2 diabetes and its complications: A multifaceted approach
Liu X, Wang X, Wang L.
Ecotoxicol Environ Saf . 2025 Sep 15:303:118914. doi: 10.1016/j.ecoenv.2025.118914.
Phenome-wide association study of male and female sex chromosome trisomies in 1.5 million participants of MVP, FinnGen, and UK Biobank
Davis SM, Liu A, Teerlink CC, Lapato DM, Gorman B, Genovese G, Singh M, Reeve MP, Gentry AE, Donner KM, Sipilä TP, Ghazal A, Pagadala MS, Panizzon MS, Lancaster EE; FinnGen; Chatzinakos C, Ganna A, Bigdeli TB, Daly MJ, Lynch JA, Ross J, Peterson RE, Hauger RL.
Am J Hum Genet . 2025 Sep 4;112(9):2088-2101. doi: 10.1016/j.ajhg.2025.07.017.
Proteomic insights into chronic pancreatitis: Proteome-wide mendelian randomization to identify potential therapeutic targets
Li Q, Chen W, Li X, Zhu Z, Yang Y, Xie Y, Zhu H.
Pancreatology . 2025 Sep;25(6):878-888. doi: 10.1016/j.pan.2025.08.014.
From background diabetic retinopathy to its proliferative stage. What is the role of gut microbiota in the trajectory of DR? a Mendelian randomization study with mediation analysis
Zhou Y, Dong J, Wang Z, Huang C, Yu X, Wang X, Yang B, Wu Y, Peng Q.
Diabetol Metab Syndr . 2025 Aug 20;17(1):346. doi: 10.1186/s13098-025-01813-6.
Investigating potential biomarkers associated with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis using Mendelian randomization and transcriptomic analysis
Yujia Wang, Zhimin Chen, Kaiqi Huang, Keng Ye, Shiwei He, Yanfang Xu, Hong Chen
Arthritis Res Ther 27, 166 (2025). https://doi.org/10.1186/s13075-025-03630-8
Potential circadian rhythm-related pathogenic genes in coronary artery disease: a Mendelian randomization study
Zhang H, Zhao Z, Shi W, Niu G, Feng D, Wang M, Zhou Z, Li Z, Zhao J, Wu Y.
Postgrad Med J . 2025 Aug 20:qgaf125. doi: 10.1093/postmj/qgaf125.
Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations
Greene CA, Hampton G, Jaworski J, Shuey MM, Khan A, Luo Y, Jarvik GP, Namjou-Khales B, Edwards TL, Velez Edwards DR, Hellwege JN.
Nat Commun 16, 7770 (2025). https://doi.org/10.1038/s41467-025-62945-x
Understanding the risk of diabetic retinopathy from glucagon-like peptide-1 receptor agonists: a Mendelian randomization study and systematic review of European populations
Shen B, Wang W, Guo Y, Chen Z, Liu C, Huang J, Li Y.
Diabetol Metab Syndr . 2025 Aug 20;17(1):345. doi: 10.1186/s13098-025-01878-3.
Unraveling the gut–immune–kidney axis in kidney stone disease: a two-step Mendelian randomization investigation
Jian Hou, Junxiong Li, Yupeng Wu, Yumin Wang, Guoqiang Liao, Runan Dong
Urolithiasis 53, 160 (2025). https://doi.org/10.1007/s00240-025-01830-0
Causal association between gut microbiota and neonatal digestive system diseases: A Mendelian randomization study
Pang J, Yang Z, Liu P, Pan B, He G, Yang S.
Medicine (Baltimore) . 2025 Aug 15;104(33):e44009. doi: 10.1097/MD.0000000000044009.
Unveiling migraine subtype heterogeneity and risk loci: integrated genome-wide association study and single-cell transcriptomics discovery
Wei S, Quan Y, Li X, Zhong S, Xiao L, Yang C, Shen R, Lu X, He L, Zhang Y, Huang X.
J Headache Pain . 2025 Aug 18;26(1):185. doi: 10.1186/s10194-025-02128-7.
Gut microbiome and diabetic kidney disease: Insights from Mendelian randomization and genetic correlations
Yang K, Zhao Z, Yin Y, Liu Y, Wu X.
Medicine (Baltimore) . 2025 Aug 15;104(33):e42492. doi: 10.1097/MD.0000000000042492.
Causal links between programmed cell death and hypertrophic scars: Integrative analysis of multi-omics Mendelian randomization and preliminary experimental validation
Zhang Y, Zhao C, Zhao R.
Burns . 2025 Aug 19;51(8):107667. doi: 10.1016/j.burns.2025.107667.
Unveiling biomarkers via plasma metabolome profiling for diabetic macrovascular and microvascular complications
Li Z, Ren Y, Jiang F, Zhang K, Meng X, Zheng Y, He M.
Cardiovasc Diabetol . 2025 Aug 18;24(1):341. doi: 10.1186/s12933-025-02899-y.
Genetic insights into alcohol-associated liver disease: integrative transcriptome-wide analysis identifies novel susceptibility genes
Wang Q, Wang Z, Hu M, Liu F, Wang Z.
Front Med (Lausanne) . 2025 Jul 31:12:1623367. doi: 10.3389/fmed.2025.1623367. eCollection 2025.
Integration of multi-omics quantitative trait loci evidence reveals novel susceptibility genes for Alzheimer’s disease
Jinyang Gao, Xiaochan Bi, Wenjing Jiang, Yanqing Wang
Sci Rep 15, 30158 (2025). https://doi.org/10.1038/s41598-025-12290-2
Two-step Mendelian randomization reveals a lipid-driven protective effect of type 2 diabetes on ALS
Kong M, Yu W, Guo J, Wang Z, Fan D.
Neurol Sci . 2025 Oct;46(10):5133-5144. doi: 10.1007/s10072-025-08407-0.
The gut microbiome and ovarian cysts: a mendelian randomization study
Jiahui Qu, Liying Zhang
J Ovarian Res 18, 188 (2025). https://doi.org/10.1186/s13048-025-01767-3
Immunocytes Mediate the Effects of Gut Microbiome on Inflammatory Bowel Disease: Insights From a Mendelian Randomization Study
He L, Wei J, Li Z, Guo S, Lin S, Wang T, Chen L.
Mediators Inflamm . 2025 Aug 8:2025:9956259. doi: 10.1155/mi/9956259. eCollection 2025.
Mendelian randomization identifies genetically predicted calorie dietary preference as causal risk factors for cancer
Kaiyuan Zhang, Jiaheng Lou, Jianbo Huang, Xiaochen Ni, Chuhang Wang, Jianing Guo, Wei Fan, Yuanlin Lv, Guangji Zhang, Tao Jiang
Discov Onc 16, 1582 (2025). https://doi.org/10.1007/s12672-025-03213-8
Dissecting the role of gut microbiota heterogeneity in the onset of chronic lung diseases
Lin Y, Zhang X, Zuo Z, Xiao Y.
AMB Express . 2025 Aug 18;15(1):119. doi: 10.1186/s13568-025-01930-5.
Investigating the potential impact of gut microbiota and immune cells on ankylosing spondylitis based on single-cell sequencing and genetic variation analysis
Jiang Xue, Tianyou Chen, Shaofeng Wu, Jiarui Chen, Sitan Feng, Chengqian Huang, Sen Mo, Zhongxian Zhou, Chenxing Zhou, Jichong Zhu, Wendi Wei, Rongqing He, Boli Qin, Xiaopeng Qin, Xinli Zhan, Chong Liu
Clin Rheumatol 44, 3967–3980 (2025). https://doi.org/10.1007/s10067-025-07595-6
Investigating the Causal Role of Neurotrophic Factors in Low Back Pain and Sciatica: A Mendelian Randomization Study
Lin F, He W.
Curr Med Chem . 2025 Aug 12. doi: 10.2174/0109298673358689250711005445.
Druggable genome-wide Mendelian randomization integrating GWAS and eQTL/pQTL data identifies targets for lung squamous cell carcinoma
Cheng S, Zhang H, Shi Z, Sun D.
Sci Rep . 2025 Aug 17;15(1):30116. doi: 10.1038/s41598-025-15977-8.
Characterising the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian Randomization
Elisabeth Aiton, Nancy S McBride, Gemma L Clayton, Ana Goncalves Soares, Tom Bond, Qian Yang, Charikleia Chatzigeorgiou, Jane West, Benjamin G Faber, Katherine Birchenall, Christy Burden, Maria C Magnus, Deborah A Lawlor, Maria Carolina Borges
medRxiv 2025.08.12.25333479; doi: https://doi.org/10.1101/2025.08.12.25333479
Mendelian Randomization Analysis Reveal the Role of Circulating Inflammatory Proteins in Mediating Functional Brain Networks and Peripheral Neuropathic Pain Effects
Liu WH, Hu HM, Li C, Shi Q, Li YF, Mao P, Fan BF.
Brain Behav. 2025 Aug;15(8):e70751. doi: 10.1002/brb3.70751.
sIL-6R impact on aortic aneurysm: Genetic evidence from FinnGen and GWAS
Wang M, Teng T, Mo D, Zhang N, Chen R, Xu J, Dong Z, Zhang N, Yu H.
Int J Cardiol. 2025 Aug 15:133786. doi: 10.1016/j.ijcard.2025.133786.
Identification of prospective novel drug targets for immune thrombocytopenia by integrating plasma proteome
He W, Zhang J, Zhao M, Fang J, He F, Zhao C.
Hematology. 2025 Dec;30(1):2545645. doi: 10.1080/16078454.2025.2545645.
Association between Sarcopenia-related traits and depression: an observational and Mendelian randomization analysis
Shitu Zhuo, Biyue Zhang, Xinxia Yang
Eur Arch Psychiatry Clin Neurosci (2025). https://doi.org/10.1007/s00406-025-02091-z
Development and validation of polygenic scores for within-family prediction of disease risks
Spencer Moore, Ivan Davidson, Jonathan Anomaly, Jeremiah H. Li, Mohammad Ahangari, Lauren Moissiy, Michael Christensen, Alexander Strudwick Young, David Stern, Tobias Wolfram
medRxiv 2025.08.06.25333145; doi: https://doi.org/10.1101/2025.08.06.25333145
Genetic Associations of Myopia and Axial Length with Diabetic Retinopathy
Kai JY, Ying ZQ, Dong XX, Lanca C, Grzybowski A, Zhang XF, Pan CW.
Ophthalmic Epidemiol. 2025 Aug 14:1-9. doi: 10.1080/09286586.2025.2546322.
Obesity- and Lipid-Related Traits May Causally Contribute to Sepsis-Associated Acute Kidney Injury
Campbell KR, Takahashi N, Shimada T, Nakada TA, Russell JA, Walley KR.
Crit Care Med. 2025 Aug 14. doi: 10.1097/CCM.0000000000006812.
Unveiling causal relationship between white matter tracts and psychiatric disorders
Yifan Yu, Tianye Jia, Xiao Lin, Yanping Bao, Suhua Chang, Jie Sun, Teng Gao, Jie Shi, Sizhi Ai, Kai Yuan
Commun Biol 8, 1221 (2025). https://doi.org/10.1038/s42003-025-08669-6
Potential protective role of Bifidobacteria in myopia prevention: evidence from full-length 16S rRNA sequencing and bidirectional Mendelian randomization analysis
Tang G, Han Y, Gong X, Wang X, Li J, Zhang J, Wang J, Song J, Bi H.
Front Med (Lausanne) . 2025 Aug 13:12:1634120. doi: 10.3389/fmed.2025.1634120.
Multi-organ AI Endophenotypes Chart the Heterogeneity of Pan-disease in the Brain, Eye, and Heart
The MULTI consortium, Aleix Boquet-Pujadas, Filippos Anagnostakis, Zhijian Yang, Ye Ella Tian, Michael R. Duggan, Guray Erus, Dhivya Srinivasan, Cassandra M. Joynes, Wenjia Bai, Praveen J. Patel, Keenan A. Walker, Andrew Zalesky, Christos Davatzikos, Junhao Wen
medRxiv 2025.08.09.25333350; doi: https://doi.org/10.1101/2025.08.09.25333350
Nanoparticle enriched mass spectrometry proteomics in British South Asians identifies novel variant-protein-disease mechanisms
Maik Pietzner, Alice Williamson, Karen A. Hunt, Mine Koprulu, Leonhard Kohleick, Kamil Demircan, Genes & Health Research Team, Sarah Finer, Julia Carrasco Zanini, David A van Heel, Claudia Langenberg
medRxiv 2025.08.12.25333522; doi: https://doi.org/10.1101/2025.08.12.25333522
PPT2 Promotes the Rectal Cancer via CD4+ Immune Cells
Gengchen Lu, Yining Zhou, Rui Wang, Lingwei Song, Zhiwei Xu, Bin Cheng
Researchsquare, 12 August 2025, doi: 10.21203/rs.3.rs-7128416/v1
Association between depression and asthma: insight from observational and genetic evidence
Tanao Ji, Yue Lv, Jianan Yang, Xianping Diao, Jun Gu
BMC Psychiatry 25, 786 (2025). https://doi.org/10.1186/s12888-025-07245-w
Genome-wide association study of borderline personality disorder identifies 11 loci and highlights shared risk with mental and somatic disorders
Fabian Streit, Swapnil Awasthi, Alisha SM Hall, Alice Braun, Maria Niarchou, Eirini Marouli, Oladapo Babajide, Josef Frank, Lea Zillich, Carolin M Callies, Diana Avetyan, Eric Zillich, Joonas Naamanka, Jean Gonzalez, Arvid Harder, Yi Lu, Zouhair Aherrahrou, Zain-Ul-Abideen Ahmad, Helga Ask, Anthony Batzler, Michael E Benros, Odette M Brand-de Wilde, Søren Brunak, Mie T Bruun, Lea AN Christoffersen, Lucía Colodro-Conde, Brandon J Coombes, Elizabeth C Corfield, Norbert Dahmen, Maria Didriksen, Khoa M Dinh, Srdjan Djurovic, Joseph Dowsett, Ole Kristian Drange, Helene Dukal, Susanne Edelmann, Christian Erikstrup, Mariana K Espinola, Eva Fassbinder, Annika Faucon, Diana S Ferreira de Sá, Jerome C Foo, Maria Gilles, Alfonso Gutiérrez-Zotes, Thomas F Hansen, Magnus Haraldsson, R. Patrick Harper, Alexandra Havdahl, Urs Heilbronner, Stefan Herms, Henrik Hjalgrim, Christopher Hübel, Gitta A Jacob, Bitten Aagaard, Anders Jorgensen, Martin Jungkunz, Nikolaus Kleindienst, Nora Knoblich, Stefanie Koglin, Julia Kraft, Kristi Krebs, Christopher W Lee, Yuhao Lin, Stefanie Lis, Amanda Lisoway, Ioannis A Malogiannis, Amy Martinsen, Tolou Maslahati, Katharina Merz, Andreas Meyer-Lindenberg, Susan Mikkelsen, Christina Mikkelsen, Arian Mobascher, Gerard Muntané, Asmundur Oddsson, Sisse R Ostrowski, Teemu Palviainen, Ole BV Pedersen, Geir Pedersen, Liam Quinn, Matthias A Reinhard, Florian A Ruths, Björn H Schott, Michael Schredl, Emanuel Schwarz, Cornelia E Schwarze, Michael Schwinn, Tabea Send, Engilbert Sigurdsson, Katja Simon-Keller, Astros T Skuladottir, Joaquim Soler, Anne Sonley, Erik Sørensen, Hreinn Stefansson, Peter Straub, Jaana Suvisaari, Martin Tesli, Jacob Træholt, Henrik Ullum, Maja P Völker, G Bragi Walters, Rujia Wang, Christian C Witt, Gerhard Zarbock, Peter Zill, John-Anker Zwart, DBDS Genomic Consortium, Estonian Biobank Research Team, the GLAD Study, HUNT All-In Psychiatry, Ole A Andreassen, Arnoud Arntz, Joanna M Biernacka, Martin Bohus, Gerome Breen, Alexander L Chapman, Sven Cichon, Lea K Davis, Michael Deuschle, Sebastian Euler, Sabine C Herpertz, Benjamin Hummelen, Andrea Jobst, Jaakko Kaprio, James L Kennedy, Kelli Lehto, Klaus Lieb, Lourdes Martorell, Shelley McMain, Richard Musil, Vanessa Nieratschker, Markus M Nöthen, Frank Padberg, Aarno Palotie, Juan C Pascual, Nader Perroud, Josep A Ramos-Quiroga, Ted Reichborn-Kjennerud, Marta Ribases, Stefan Roepke, Dan Rujescu, Sandra Sanchez-Roige, Claudia Schilling, Christian Schmahl, Kari Stefansson, Thorgeir E Thorgeirsson, Gustavo Turecki, Elisabet Vilella, Thomas Werge, Bendik S Winsvold, Johannes Wrege, Marcella Rietschel, Stephan Ripke, Stephanie H Witt
medRxiv 2024.11.12.24316957; doi: https://doi.org/10.1101/2024.11.12.24316957