Below you will find all the published and preprint scientific papers using FinnGen data.

2024

February

Circulating micronutrient levels and their association with sepsis susceptibility and severity: a Mendelian randomization study
Wei Z, Liu Y, Mei X, Zhong J, Huang F.
Front Genet. 2024 Feb 16;15:1353118. doi: 10.3389/fgene.2024.1353118.
Effect of viral hepatitis on type 2 diabetes: A Mendelian randomization study
Yu YF, Hu G, Tong KK, Yang XY, Wu JY, Yu R.
World J Diabetes. 2024 Feb 15;15(2):220-231. doi: 10.4239/wjd.v15.i2.220.
The causal effect of air pollution on the risk of essential hypertension: a Mendelian randomization study
Xia Z, Liu Y, Liu C, Dai Z, Liang X, Zhang N, Wu W, Wen J, Zhang H.
Front Public Health. 2024 Feb 15;12:1247149. doi: 10.3389/fpubh.2024.1247149.
Associations between gut microbiota and adverse neurodevelopmental outcomes in preterm infants: a two-sample Mendelian randomization study
Wang Y, Cheng T, Cui Y, Qu D, Peng X, Yang L, Xiao X.
Front Neurosci. 2024 Feb 14;18:1344125. doi: 10.3389/fnins.2024.1344125.
Causality Assessment Between Idiopathic Inflammatory Myopathies and Lung Cancer: A Bidirectional 2-Sample Mendelian Randomization
Li H, Xu Y, Guo Q, Zhang T, Zhou S, Wang Q, Tian Y, Cheng Y, Guo C.
J Clin Rheumatol. 2024 Feb 14. doi: 10.1097/RHU.0000000000002075.
The Relationship Between Systemic Lupus Erythematosus and Osteoporosis Based on Different Ethnic Groups: a Two-Sample Mendelian Randomization Analysis
Shi YK, Yuan KH, Fu ZM, Hu RR, Wang H.
Calcif Tissue Int. 2024 Feb 14. doi: 10.1007/s00223-024-01190-8.
Assessing the causal relationship between psychiatric disorders and obstructive sleep apnea: a bidirectional Mendelian randomization
Mi C, Hou A, Liu Y, Qi X, Teng J.
Front Psychiatry. 2024 Feb 14;15:1351216. doi: 10.3389/fpsyt.2024.1351216.
Genomics-Microbiome Based Assessment of Bidirectional Causality Between Gut Microbiota and Psoriasis
Gao Q, Liu JH, Ma WY, Cheng ZL, Hao PS, Luo NN.
Clin Cosmet Investig Dermatol. 2024 Feb 13;17:435-445. doi: 10.2147/CCID.S450227.
Evaluation of bidirectional causal association between cardiovascular diseases and pneumonia: A Mendelian randomization study
Zhang Y, Liu H, Dai Y, Ye F, Luo W, Tu S, Chen W, Kong S, He Y, Tan N, Zhang Z, He P, Liu Y.
Eur J Prev Cardiol. 2024 Feb 13:zwae060. doi: 10.1093/eurjpc/zwae060.
Causal association of smoking, blood lipids, and bladder cancer: Insights from a multivariable and mediation mendelian randomization investigation
Wei H, Cheng X, Wang G, Li Z, Du W, Ju L, Shan D, Yu M, Fang Y, Qian K, Zhang Y, Xiao Y, Wang X.
J Cancer. 2024 Feb 12;15(7):1929-1939. doi: 10.7150/jca.92306.
Dietary factors and the risk of atopic dermatitis: A Mendelian randomization study
Che Y, Yuan J, Wang Q, Liu M, Tang D, Chen M, Xiao X, Pang Y, Chen S, Han W, Xiao Z, Zeng J, Guo J.
Br J Nutr. 2024 Feb 12:1-31. doi: 10.1017/S0007114524000436.
Disentangling the link between maternal influences on birth weight and disease risk in 36,211 genotyped mother-child pairs
Leinonen JT; FinnGen; Pirinen M, Tukiainen T.
Commun Biol. 2024 Feb 12;7(1):175. doi: 10.1038/s42003-024-05872-9.
Gut microbiota and risk for the diverticular disease of intestine
Wenhui He, Youzhen Yu, Na Luo, Shangqing Xu, Wenwen Yang, Fanfan Li, Hui Zhu, Hongying Jin, Yimei Zhang, Xiaoli Ma, Minjie Ma
Researchsquare, 11 January 2024, https://doi.org/10.21203/rs.3.rs-3834819/v1
Genetically proxied PCSK9 inhibition is associated with reduced psoriatic arthritis risk
Li J, Li J, Lin C, Zhou J, Wang J, Wang F, Li H, Zhou Z.
Inflamm Res. 2024 Feb 11. doi: 10.1007/s00011-024-01850-3.
Genetic link between primary biliary cholangitis and connective tissue diseases in European populations: A two-sample Mendelian randomization study
Liu Z, Shao Y, Duan X.
PLoS One. 2024 Feb 9;19(2):e0298225. doi: 10.1371/journal.pone.0298225.
Bacteroidaceae, Bacteroides, and Veillonella: emerging protectors against Graves' disease
Liu S, Li F, Cai Y, Ren L, Sun L, Gang X, Wang G.
Front Cell Infect Microbiol. 2024 Feb 9;14:1288222. doi: 10.3389/fcimb.2024.1288222.
Assessing causality between chronic obstructive pulmonary disease with depression: A bidirectional Mendelian randomization study
Liu A, Hong PY, Su B, Wu JH, Chen ZY.
J Affect Disord. 2024 Feb 8:S0165-0327(24)00331-8. doi: 10.1016/j.jad.2024.02.022.
Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis
Tang J, Mo S, Fan L, Fu S, Liu X.
Front Immunol. 2024 Feb 8;15:1284466. doi: 10.3389/fimmu.2024.1284466.
Genetic Analysis of Obstructive Sleep Apnea and Its Relationship with Severe COVID-19
Strausz S, Agafonova E, Tiullinen V, Kiiskinen T, Broberg M, Ruotsalainen SE, Koskela J, Bachour A, Sofer T, Gottlieb DJ, Palotie A, Palotie T, Ripatti S, Ollila HM.
Ann Am Thorac Soc. 2024 Feb 8. doi: 10.1513/AnnalsATS.202303-215OC.
Association between hypothyroidism subtypes and major depression: A two-sample Mendelian randomization study
Zhou H, Zhu H, Wang J, Gao X, Jiang C.
J Affect Disord. 2024 Feb 8:S0165-0327(24)00315-X. doi: 10.1016/j.jad.2024.02.006.
Association between human blood metabolome and the risk of pre-eclampsia
Ding Y, Yao M, Liu J, Fu W, Zhu X, He Y, Ma Q, Zhang C, Yin J.
Hypertens Res. 2024 Feb 8. doi: 10.1038/s41440-024-01586-x.
Inflammatory cytokines and oral lichen planus: a Mendelian randomization study
Chen X, Zhang S, Wu X, Lei Y, Lei B, Zhao Z.
Front Immunol. 2024 Feb 7;15:1332317. doi: 10.3389/fimmu.2024.1332317.
Causal associations between gut microbiota, metabolites and asthma: a two-sample Mendelian randomization study
Li J, Zhang C, Tang J, He M, He C, Pu G, Liu L, Sun J.
BMC Pulm Med. 2024 Feb 7;24(1):72. doi: 10.1186/s12890-024-02898-x.
Association between Daytime Napping and Incident Arrhythmias: A Prospective Cohort Study and a Mendelian Randomization Analysis
Gao QY, Zhang HF, Gao JW, Cai JW, Chen Q, You S, Chen ZT, Guo DC, Li ST, Hao QY, Liu PM, Wang JF, Chen YX.
Heart Rhythm. 2024 Feb 7:S1547-5271(24)00114-0. doi: 10.1016/j.hrthm.2024.02.004.
Causal relationship between gut microbiota and autoimmune thyroiditis: A mendelian study
Xiong Y, Zhu X, Luo Q.
Heliyon. 2024 Feb 6;10(3):e25652. doi: 10.1016/j.heliyon.2024.e25652.
Association between green tea intake and digestive system cancer risk in European and East Asian populations: a Mendelian randomization study
Nie D, He X, Zheng H, Deng D, He F, Li R, Ni X, Li S, Xu F.
Eur J Nutr. 2024 Feb 6. doi: 10.1007/s00394-023-03312-8.
Identification of the VLDLR locus associated with giant cell arteritis and the possible causal role of low-density lipoprotein cholesterol in its pathogenesis
Iwasaki T, Watanabe R, Zhang H, Hashimoto M, Morinobu A, Matsuda F.
Rheumatology (Oxford). 2024 Feb 6:keae075. doi: 10.1093/rheumatology/keae075.
The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases
Ryguła I, Pikiewicz W, Grabarek BO, Wójcik M, Kaminiów K.
Int J Mol Sci. 2024 Feb 6;25(4):1984. doi: 10.3390/ijms25041984.
Genetic evidence of the causal relationship between chronic liver diseases and musculoskeletal disorders
Lu Z, Li X, Qi Y, Li B, Chen L.
J Transl Med. 2024 Feb 6;22(1):138. doi: 10.1186/s12967-024-04941-1.
Hypothyroidism is a causal determinant of age-related cataract risk in European population: a Mendelian randomization study
Liu S, Sun Q, Gu Q, Bao Y, Wang W, Qin X, Yuan X.
Front Endocrinol (Lausanne). 2024 Feb 5;15:1254793. doi: 10.3389/fendo.2024.1254793.
Evidence for Genetic Causal Relationships Between Multiple Immune-Mediated Inflammatory Diseases and Age-Related Macular Degeneration: A Univariable and Multivariable Mendelian Randomization Study
Sha F, Li H, Zhang L, Liang F.
Ophthalmol Ther. 2024 Feb 5. doi: 10.1007/s40123-024-00895-1.
Unraveling the mystery: a Mendelian randomized exploration of gut microbiota and different types of obesity
Liu S, Li F, Cai Y, Ren L, Sun L, Gang X, Wang G.
Front Cell Infect Microbiol. 2024 Feb 5;14:1352109. doi: 10.3389/fcimb.2024.1352109.
Causal relationships of physical activity and leisure sedentary behaviors with COPD: A Mendelian randomization study
Gao Y, Li C, Li J, Li L.
Arch Gerontol Geriatr. 2024 Feb 5;121:105364. doi: 10.1016/j.archger.2024.105364.
Associations between ADHD and risk of six psychiatric disorders: a Mendelian randomization study
Guo Y, Li J, Hu R, Luo H, Zhang Z, Tan J, Luo Q.
BMC Psychiatry. 2024 Feb 5;24(1):99. doi: 10.1186/s12888-024-05548-y.
Effects of menstrual disorders and dysmenorrhea on cardiovascular disease: a Mendelian randomization study
Lai S, Jin Q, Wang D, Li T, Wang X.
Front Endocrinol (Lausanne). 2024 Feb 5;15:1302312. doi: 10.3389/fendo.2024.1302312.
Identifying novel proteins for suicide attempt by integrating proteomes from brain and blood with genome-wide association data
Zhao H, Liu Y, Zhang X, Liao Y, Zhang H, Han X, Guo L, Fan B, Wang W, Lu C.
Neuropsychopharmacology. 2024 Feb 5. doi: 10.1038/s41386-024-01807-4.
Bidirectional two-sample Mendelian randomization analysis identifies causal associations between cardiovascular diseases and frozen shoulder
Lu W, Pu B, Wang S, Li M, An Y, Lian J, Wang Y.
J Orthop Surg Res. 2024 Feb 3;19(1):116. doi: 10.1186/s13018-024-04600-7.
Causal association between adiponectin and risk of trigeminal neuralgia: A Mendelian randomization study
Kong Y, Yin C, Qiu C, Kong W, Zhao W, Wang Y.
Clin Neurol Neurosurg. 2024 Feb 3;237:108154. doi: 10.1016/j.clineuro.2024.108154.
Revisiting an old relationship: the causal associations of the ApoB/ApoA1 ratio with cardiometabolic diseases and relative risk factors-a mendelian randomization analysis
Fu C, Liu D, Liu Q, Wang X, Ma X, Pan H, Feng S, Sun Z, Qiao W, Yang M, Gao S, Ding H, Huang X, Hou J.
Cardiovasc Diabetol. 2024 Feb 3;23(1):51. doi: 10.1186/s12933-024-02140-2.
Assessing Genetic Causality of Periodontal Disease and Atrial Fibrillation by Potential Mediators: A Two-Step Mediating Mendelian Randomization Study
Chengzhong Lian, Xiaohan Zhang, Jiaran Li, Jing Shi, Shuqing Shi, Lianxin Wang, Zezhen Guo, Naixu Liu, Huan Wang, Shuai Shi, Yuanhui Hu, Bai Du
Researchsquare, 02 February 2024, doi: 10.21203/rs.3.rs-3881463/v1
Association of asthma and lung cancer risk: A pool of cohort studies and Mendelian randomization analysis
Huang Q, Huang Y, Xu S, Yuan X, Liu X, Chen Z.
Medicine (Baltimore). 2024 Feb 2;103(5):e35060. doi: 10.1097/MD.0000000000035060.
The epidemiology of pregnancy loss: global burden, variable risk factors, and predictions
Tong F, Wang Y, Gao Q, Zhao Y, Zhang X, Li B, Wang X.
Hum Reprod. 2024 Feb 2:deae008. doi: 10.1093/humrep/deae008.
Effect of tea intake on genetic predisposition to gout and uric acid: a Mendelian randomization study
Yu Y, Yang X, Hu G, Tong K, Yin Y, Yu R.
Front Endocrinol (Lausanne). 2024 Feb 2;14:1290731. doi: 10.3389/fendo.2023.1290731.
Causal Associations of Modifiable Risk Factors With Migraine: Evidence From Mendelian Randomization Analysis
Jareebi MA, Lyall DM, Gharawi NF, Shami MO, Dahas N, Alfaifi RF, Hakami A, Darraj MA, Hakami FA, Hakami MH, Almalki HM, Hakami ZT, Alessa A, Alhazmi AA.
Cureus. 2024 Feb 2;16(2):e53448. doi: 10.7759/cureus.53448.
Identification of systemic biomarkers and potential drug targets for age-related macular degeneration
Lei S, Hu M, Wei Z.
Front Aging Neurosci. 2024 Feb 1;16:1322519. doi: 10.3389/fnagi.2024.1322519.
Assessment of Causality Between Diet-Derived Antioxidants and Primary Open-Angle Glaucoma: A Mendelian Randomization Study
Xiong K, Zhang Q, Mao H, Congdon N, Liang Y.
Transl Vis Sci Technol. 2024 Feb 1;13(2):20. doi: 10.1167/tvst.13.2.20.
Exploring the causal relationship between 91 inflammatory cytokines and two subtypes of rheumatoid arthritis: a bidirectional two-sample Mendelian randomization study
Wenjie Gao, Jianan Chen, Muxu Zheng, Nianchun Liao, Song Liu, Huihong Shi, Wenjun Hu, Yanbo Chen, Dongsheng Huang, Youxi Lin, Anjing Liang
Researchsquare, 01 February 2024, doi:10.21203/rs.3.rs-3904925/v1

January

Fruit Intake and Alzheimer's Disease: Results from Mendelian Randomization
Liao WZ, Zhu XF, Xin Q, Mo YT, Wang LL, He XP, Guo XG.
J Prev Alzheimers Dis. 2024;11(2):445-452. doi: 10.14283/jpad.2024.31.
Causal relationship between inflammatory bowel disease and erythema nodosum: A two-sample bidirectional Mendelian randomization study
Zhu H, Jiang Y, Ma G, Xu Y, Pan J.
Skin Res Technol. 2024 Feb;30(2):e13600. doi: 10.1111/srt.13600.
Associations of genetically dating proteins with breast cancer risk or survival
Hanghang Chen, Qi Liu, Xufeng Cheng
Researchsquare, 31 January 2024, doi:10.21203/rs.3.rs-3906265/v1