Below you will find all the published and preprint scientific papers using FinnGen data.

2023

November

Correlation between diabetic retinopathy and diabetic nephropathy: a two-sample Mendelian randomization study
Fang J, Luo C, Zhang D, He Q, Liu L
Front Endocrinol (Lausanne). 2023 Nov 1;14:1265711. doi: 10.3389/fendo.2023.1265711

October

Genetic causal relationship between gut microbiome and psoriatic arthritis: a bidirectional two-sample Mendelian randomization study
Qian X, Fu Z, Diao C, Zhang W, Tao W, Hu J, Zhang S, Zhao D
Front Microbiol. 2023 Oct 31;14:1265786. doi: 10.3389/fmicb.2023.1265786
Association between Liver MRI Proton Density Fat Fraction and Liver Disease Risk
Xia T, Du M, Li H, Wang Y, Zha J, Wu T, Ju S
Radiology. 2023 Oct;309(1):e231007. doi: 10.1148/radiol.231007
No evident causal association between Helicobacter pylori infection and colorectal cancer: a bidirectional mendelian randomization study
Luo F, Zhou P, Ran X, Gu M, Zhou S
Sci Rep. 2023 Oct 29;13(1):18544. doi: 10.1038/s41598-023-45545-x
Increased risk of dementia differs across cardiovascular diseases and types of dementia - Data from a nationwide study
Kauko A, Engler D, Niiranen T, Ortega-Alonso A, Schnabel RB
J Intern Med. 2023 Oct 29. doi: 10.1111/joim.13733
A bidirectional Mendelian randomisation study to evaluate the relationship between body constitution and hearing loss
He Y, Karhunen V, Pulakka A, Kantomaa M, Sebert S
Sci Rep. 2023 Oct 27;13(1):18434. doi: 10.1038/s41598-023-44735-x
A Mendelian randomization study revealed a causal link between napping and deep vein thrombosis (DVT)
Yan D, Liu G, Yin Y, Zhang Q, Shi D, Zhang J, Li Y
Sleep Breath. 2023 Oct 26. doi: 10.1007/s11325-023-02940-y
Causality Investigation between Gut Microbiota, Derived Metabolites, and Obstructive Sleep Apnea: A Bidirectional Mendelian Randomization Study
Yan W, Jiang M, Hu W, Zhan X, Liu Y, Zhou J, Ji J, Wang S, Tai J
Nutrients. 2023 Oct 26;15(21):4544. doi: 10.3390/nu15214544
The association between thyroid and breast cancers: a bidirectional mendelian randomization study
Liu J, Liang L
Front Endocrinol (Lausanne). 2023 Oct 25;14:1185497. doi: 10.3389/fendo.2023.1185497
Risk factors for severe respiratory syncytial virus infection during the first year of life: development and validation of a clinical prediction model
Vartiainen P, Jukarainen S, Rhedin SA, Prinz A, Hartonen T, Vabalas A, Viippola E, Rodosthenous RS, Koskelainen S, Liu A, Lundholm C, Smew AI, Osvald EC, Helle E, Perola M, Almqvist C, Heinonen S, Ganna A.
Lancet Digit Health. 2023 Nov;5(11):e821-e830. doi: 10.1016/S2589-7500(23)00175-9.
Causal association between uric acid levels and the risk of aortic aneurysm and aortic dissection: A two-sample Mendelian randomization study.
Chen J, Zhang X, Yao H, Pang J
Nutr Metab Cardiovasc Dis. 2023 Oct 24:S0939-4753(23)00427-1. doi: 10.1016/j.numecd.2023.10.020
Genome-wide association study of traumatic brain injury in U.S. military veterans enrolled in the VA million veteran program
Merritt VC, Maihofer AX, Gasperi M, Chanfreau-Coffinier C, Stein MB, Panizzon MS, Hauger RL, Logue MW, Delano-Wood L, Nievergelt CM.
Mol Psychiatry. 2023 Oct 24. doi: 10.1038/s41380-023-02304-8.
Relationship between gut microbiota and intussusception: an analysis based on Mendelian randomization
Feng Cheng, Chun Luo, KeLei Shang, XiaoGuang Tan
Researchsquare, 24 October 2023, doi: 10.21203/rs.3.rs-3420042/v1
Bidirectional Mendelian Randomization Study of Personality Traits Reveals a Positive Feedback Loop Between Neuroticism and Back Pain
Elgaeva EE, Williams FMK, Zaytseva OO, Freidin MB, Aulchenko YS, Suri P, Tsepilov YA
J Pain. 2023 Oct;24(10):1875-1885. doi: 10.1016/j.jpain.2023.05.012
Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci
Pasanen A, Karjalainen MK; FinnGen; Zhang G, Tiensuu H, Haapalainen AM, Ojaniemi M, Feenstra B, Jacobsson B, Palotie A, Laivuori H, Muglia LJ, Rämet M, Hallman M.
PLoS Genet. 2023 Oct 23;19(10):e1010982. doi: 10.1371/journal.pgen.1010982.
The causal relationship between C-reactive protein and idiopathic pulmonary fibrosis: A univariate and multivariate Mendelian randomization study
Qiuping Yang, Xuefen Chen, Yuhhua Zhang, Qi Wu
Researchsquare, 17 October 2023, doi:10.21203/rs.3.rs-3433170/v1
Association of plasma branched-chain amino acid with multiple cancers: A mendelian randomization analysis
Xu H, Wang X, Xu X, Liu L, Zhang Y, Yan X, Zhang Y, Dang K, Li Y
Clin Nutr. 2023 Oct 23;42(12):2493-2502. doi: 10.1016/j.clnu.2023.10.019
Causal effects of gut microbiota on scoliosis: A bidirectional two-sample mendelian randomization study
Lai B, Jiang H, Gao Y, Zhou X
Heliyon. 2023 Oct 27;9(11):e21654. doi: 10.1016/j.heliyon.2023.e21654
Vitamin D and hyperemesis gravidarum: A Mendelian randomization study
Hu F
J Gynecol Obstet Hum Reprod. 2023 Oct 20:102678. doi: 10.1016/j.jogoh.2023.102678
The associations of alcoholic liver disease and nonalcoholic fatty liver disease with bone mineral density and the mediation of serum 25-Hydroxyvitamin D: A bidirectional and two-step Mendelian randomization
Huang Q, Guo J, Zhao H, Zheng Y, Zhang Y
PLoS One. 2023 Oct 19;18(10):e0292881. doi: 10.1371/journal.pone.0292881
Determining the targets of of licorice against postmenopausal osteoporosis: A drug target mendelian randomization study followed network pharmacology analysis
Shan Shan, Yijie Chen, Zhifen Zhang
Researchsquare, 19 October 2023, doi: 10.21203/rs.3.rs-3452254/v1
The relationship between COVID-19, depressive disorder, and anxiety: a bidirectional Mendelian randomization study
Zihao L, Jinyun S, Shuanglin G, Xiuzhen C, Yonglin L, Hongyu Z
Front Psychiatry. 2023 Oct 19;14:1257553. doi: 10.3389/fpsyt.2023.1257553
The causality between gut microbiome and liver cirrhosis: a bi-directional two-sample Mendelian randomization analysis
Xiao QA, Yang YF, Chen L, Xie YC, Li HT, Fu ZG, Han Q, Qin J, Tian J, Zhao WJ, Cai F, Hu YT, Ai LF, Li C, Chen XY, Wang D, Tan YY, Xia X, Zhang XL
Front Microbiol. 2023 Oct 18;14:1256874. doi: 10.3389/fmicb.2023.1256874
Interaction between Genetic Risks and Socioeconomic Factors on Thyroid Cancer: Evidence from 0.5 Million UK Biobank Participants
Li Y, Zhan Y, Mao W, Wang B, Dong P, Na R
Cancers (Basel). 2023 Oct 18;15(20):5028. doi: 10.3390/cancers15205028
Causal Relationships Between Myasthenia Gravis and Gut Microbiota by Mendelian Randomization Analysis
Jiahui Wang, Jing Wang, Xihao Wang, Qifeng Yao, Jianghua Ying, Yueyu Huang, Weiming Mao, An Zhao
Researchsquare, 17 October 2023, doi: 10.21203/rs.3.rs-3440195/v1
Understanding and Predicting Polycystic Ovary Syndrome through Shared Genetics with Testosterone, SHBG, and Chronic Inflammation
Kay Petersen L, Brixi G, Li J, Hu J, Wang Z, Han X, Yaskolka Meir A, Tyrmi J, MahKalingaiah S, Piltonen T, Liang L
medRxiv 2023.10.17.23297115; doi: https://doi.org/10.1101/2023.10.17.23297115
Association between gut microbiota and sensorineural hearing loss: a Mendelian randomization study
Yin Q, Shi G, Zhu L
Front Microbiol. 2023 Oct 17;14:1230125. doi: 10.3389/fmicb.2023.1230125
Association between gut microbiota and influenza: a bidirectional two-sample mendelian randomization study
Xu F, Gan X, Tao Y, Li D, Xie P, Liu F, Yang F, Ma Y
BMC Infect Dis. 2023 Oct 17;23(1):692. doi: 10.1186/s12879-023-08706-x
Major depressive disorder and chronic gastritis: A bidirectional two-sample Mendelian randomization study
Li J, Chen X, Yin M, Lan X, Xie L, Huang W, Luo M, Ai Y, He J
J Psychosom Res. 2023 Oct;173:111458. doi: 10.1016/j.jpsychores.2023.111458
Associations of non-alcoholic fatty liver disease and cirrhosis with liver cancer in European and East Asian populations: A Mendelian randomization study
Deng Y, Huang J, Wong MCS
Cancer Rep (Hoboken). 2023 Oct 16:e1913. doi: 10.1002/cnr2.1913
Causal relationship between coffee intake and neurological diseases: a Mendelian randomization study
Zhang J, Liu Y, Xu G, Cao X, Wang W, Zhang D, Zhu M
Eur J Clin Nutr. 2023 Oct 16. doi: 10.1038/s41430-023-01355-y
Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits
Mocci E, Ward K, Perry JA, Starkweather A, Stone LS, Schabrun SM, Renn C, Dorsey SG, Ament SA
PLoS Genet. 2023 Oct 16;19(10):e1010977. doi: 10.1371/journal.pgen.1010977
Relationship Between Helicobacter Pylori Infection and Chronic Respiratory Disease: A Two-sample Mendelian Randomization Study
Guobing Jia, Tao Guo, Chengshi He
Researchsquare, 16 October 2023, doi:10.21203/rs.3.rs-3420975/v1
Causality of occupational exposure on rheumatoid arthritis and ankylosing spondylitis: a two-sample mendelian randomization study
Du K, Zhang CY, Li A, Hu JZ, Guo R, Li SM
Front Immunol. 2023 Oct 2;14:1223810. doi: 10.3389/fimmu.2023.1223810
Causal Associations Between Gut Microbiota and Psoriasis: A Mendelian Randomization Study
Zang C, Liu J, Mao M, Zhu W, Chen W, Wei B
Dermatol Ther (Heidelb). 2023 Oct;13(10):2331-2343. doi: 10.1007/s13555-023-01007-w
Causal effects of genetically predicted endometriosis on breast cancer: a two-sample Mendelian randomization study
Yan S, Li J, Chen J, Chen Y, Qiu Y, Zhou Y, Wu W
Sci Rep. 2023 Oct 12;13(1):17307. doi: 10.1038/s41598-023-43999-7
The causal effect of obesity on the risk of 15 autoimmune diseases: a Mendelian randomization study
Li X, Zhu J, Zhao W, Zhu Y, Zhu L, Shi R, Wang Z, Pan H, Wang D.
Obes Facts. 2023 Oct 12. doi: 10.1159/000534468
Novel Finnish-enriched variants causing severe hypercholesterolemia and their clinical impact on coronary artery disease
Junna N, Ruotsalainen S, Ripatti P, FinnGen, Ripatti S, Widén E
Atherosclerosis. 2023 Oct 12:117327. doi: 10.1016/j.atherosclerosis.2023.117327
Causal effects of inflammatory bowel diseases on the risk of kidney stone disease: a two-sample bidirectional mendelian randomization
Zhang H, Huang Y, Zhang J, Su H, Ge C
BMC Urol. 2023 Oct 12;23(1):162. doi: 10.1186/s12894-023-01332-4
Inflammatory bowel disease and the risk of intracerebral hemorrhage: A Mendelian randomization study and meta-analysis
Song Y, Zou X, Zeng Y, Zhang L, Mao X
Immun Inflamm Dis. 2023 Oct;11(10):e1048. doi: 10.1002/iid3.1048.
The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study
Sun W, Yang F, Yang Y, Su X, Xing Y
Front Genet. 2023 Oct 10;14:1266869. doi: 10.3389/fgene.2023.1266869
Causal associations between plasma ADAMTS-5 protein level and cancer risk: a bi-directional mendelian randomization analysis
Rongzhi Huang, Tanli Lu, Jihao Qin, Xiaowen Fang, Chenxi Liang, Siyu Li, Jiehua Li
Researchsquare, 10 October 2023, doi: 10.21203/rs.3.rs-3397054/v1
Serum uric acid levels and risk of gastrointestinal cancers: a comprehensive Mendelian randomization study
Zhijie Xiong, Wenfeng Ning, Yonggui Li
Researchsquare, 10 October 2023, doi:10.21203/rs.3.rs-3407808/v1
Causal association between inflammatory bowel disease and 32 site-specific extracolonic cancers: a Mendelian randomization study
Gao H, Zheng S, Yuan X, Xie J, Xu L
BMC Med. 2023 Oct 10;21(1):389. doi: 10.1186/s12916-023-03096-y
Visceral and ectopic fat are more predictively associated with primary liver cancer than overall obesity from genetic sights: A Mendelian randomization study
Xu FQ, Xu QY, Zhu ZJ, Jin L, Ye TW, Du CF, Gao ZY, Huang XK, Zhang Z, Jin LM, Yao WF
Int J Cancer. 2023 Oct 10. doi: 10.1002/ijc.34751
Correlation study of malignant lymphoma and breast Cancer in different gender European populations: mendelian randomization analysis
Chen X, Hu G
BMC Genom Data. 2023 Oct 9;24(1):59. doi: 10.1186/s12863-023-01162-1
The effect of metformin on urate metabolism: Findings from observational and Mendelian randomization analyses
Dai H, Hou T, Wang Q, Zhu Z, Zhu Y, Zhao Z, Li M, Xu Y, Lu J, Wang T, Ning G, Wang W, Bi Y, Zheng J, Xu M.
Diabetes Obes Metab. 2023 Oct 9. doi: 10.1111/dom.15310
Inflammatory arthritis and eye diseases: a Mendelian randomization study
Nie X, Liu Z, Xie D, Sun Y
Front Endocrinol (Lausanne). 2023 Oct 9;14:1251167. doi: 10.3389/fendo.2023.1251167
Mendelian randomization study confirms causal relationship between myopia and vitreous disorders
Xu J, Mo Y
BMC Med Genomics. 2023 Oct 9;16(1):238. doi: 10.1186/s12920-023-01673-x
Low levels of small HDL particles predict but do not influence risk of sepsis
Hamilton F, Pedersen KM, Ghazal P, Nordestgaard BG, Smith GD
Crit Care. 2023 Oct 9;27(1):389. doi: 10.1186/s13054-023-04589-1