Below you will find all the published and preprint scientific papers using FinnGen data.

2024

July

Causal effects of autoimmune diseases on temporomandibular disorders and the mediating pathways: a Mendelian randomization study
Chen X, Cheng Z, Xu J, Wang Q, Zhao Z, Jiang Q.
Front Immunol. 2024 Jul 9;15:1390516. doi: 10.3389/fimmu.2024.1390516.
Effect of Relative Protein Intake on Hypertension and Mediating Role of Physical Fitness and Circulating Fatty Acids: A Mendelian Randomization Study
Ye C, Liu D, Kong L, Wang Y, Dou C, Xu M, Zheng J, Zheng R, Li M, Zhao Z, Lu J, Chen Y, Wang W, Bi Y, Xu Y, Wang T, Ning G.
Mayo Clin Proc. 2024 Jul 9:S0025-6196(24)00105-8. doi: 10.1016/j.mayocp.2024.02.019.
Association between blood metabolites and basal cell carcinoma risk: a two-sample Mendelian randomization study
Wu B, Pan F, Wang Q, Liang Q, Qiu H, Zhou S, Zhou X.
Front Endocrinol (Lausanne). 2024 Jul 9;15:1413777. doi: 10.3389/fendo.2024.1413777.
Mendelian randomization analysis reveals higher whole body water mass may increase risk of bacterial infections
Yan P, Yao J, Ke B, Fang X.
BMC Med Genomics. 2024 Jul 9;17(1):183. doi: 10.1186/s12920-024-01950-3.
Platelet indices and inflammatory bowel disease: a Mendelian randomization study
Li HY, Liu TM.
Front Immunol. 2024 Jul 9;15:1377915. doi: 10.3389/fimmu.2024.1377915.
Genetic correlation and causal relationship between sleep and myopia: a mendelian randomization study
Zhu G, Tian R, Zhou D, Qin X.
Front Genet. 2024 Jul 9;15:1378802. doi: 10.3389/fgene.2024.1378802.
Causal relationship between central corneal thickness and open-angle glaucoma: Evidence from Mendelian randomization
Chen J, Cao X, Chen X, Li Z, Chen X, Huang S, Xie R, Ye G, Wen Y, Zhuo Y, Wei Y, Zhu Y.
Exp Eye Res. 2024 Jul 9;246:110000. doi: 10.1016/j.exer.2024.110000.
Autoimmune hypothyroidism GWAS reveals independent autoimmune and thyroid-specific contributions and an inverse relation with cancer risk
Reeve M, Kanai M, Graham D, Karjalainen J, Luo S, Kolosov N, Adams C, Ritari J, Karczewski K, Kiiskinen T, Fuller Z, Mehtonen J, Kurki M, Khan Z, Partanen J, McCarthy M, Artomov M, Tuomi T, Pirinen M, Kero J, Xavier R, Daly M, Ripatti S, Gen F.
Res Sq [Preprint]. 2024 Jul 8:rs.3.rs-4626646. doi: 10.21203/rs.3.rs-4626646/v1.
Causal relationships of lifestyle behaviours and body fat distribution on diabetic microvascular complications: a Mendelian randomization study
Guo N, Shi H, Zhao H, Abuduani Y, Chen D, Chen X, Wang H, Li P.
Front Genet. 2024 Jul 8;15:1381322. doi: 10.3389/fgene.2024.1381322.
A Genome-Wide Association Study Suggests New Susceptibility Loci for Primary Antiphospholipid Syndrome
Casares-Marfil D, Martínez-Bueno M, Borghi MO, Pons-Estel G; PRECISESADS Clinical Consortium; Reales G, Zuo Y, Espinosa G, Radstake T, van den Hoogen LL, Wallace C, Guthridge J, James JA, Cervera R, Meroni PL, Martin J, Knight JS, Alarcón-Riquelme ME, Sawalha AH.
Arthritis Rheumatol. 2024 Jul 8. doi: 10.1002/art.42947.
Role of circulating inflammatory protein in the development of diabetic renal complications: proteome-wide Mendelian randomization and colocalization analyses
Liu W, Zhang J, Zhang D, Zhang L.
Front Endocrinol (Lausanne). 2024 Jul 8;15:1406442. doi: 10.3389/fendo.2024.1406442.
Identification of Causal Risk Factors for Pan-Cancers: a Mendelian Randomization Study
Du B, Fan L, Tang C, Xu S, Ge J, Shang X.
medRxiv 2024.07.06.24309341; doi: https://doi.org/10.1101/2024.07.06.24309341
Identifying novel potential drug targets for endometriosis via plasma proteome screening
Tao T, Mo X, Zhao L.
ront Endocrinol (Lausanne). 2024 Jul 5;15:1416978. doi: 10.3389/fendo.2024.1416978.
Causal relationship between bone mineral density and intervertebral disc degeneration: a univariate and multivariable mendelian randomization study
Li L, Li D, Geng Z, Huo Z, Kang Y, Guo X, Yuan B, Xu B, Wang T.
BMC Musculoskelet Disord. 2024 Jul 5;25(1):517. doi: 10.1186/s12891-024-07631-7.
Abdominal aortic aneurysm and cardiometabolic traits share strong genetic susceptibility to lipid metabolism and inflammation
Zheng S, Tsao PS, Pan C.
Nat Commun. 2024 Jul 5;15(1):5652. doi: 10.1038/s41467-024-49921-7.
Occlusion dysfunction and Alzheimer's disease: Mendelian randomization study
Wang Q, Zhen W, Hu R, Wang Z, Sun Y, Sun W, Huang C, Xu J, Zhang H.
Front Aging Neurosci. 2024 Jul 5;16:1423322. doi: 10.3389/fnagi.2024.1423322.
Genetic evidence for causal association between migraine and dementia: a mendelian randomization study
Chen Q, Zhang C, Wu S, He Y, Liu Y, Zheng L, Li B, Liu G, Liu L.
BMC Med Genomics. 2024 Jul 5;17(1):180. doi: 10.1186/s12920-024-01956-x.
Mitochondrial biological function and risk of atrial fibrillation and atrial flutter: A 2-sample Mendelian randomization study
Zhang T, Chen H, Shi Y, Jin Y, Zhang Y, An S, Chen Y.
Medicine (Baltimore). 2024 Jul 5;103(27):e38631. doi: 10.1097/MD.0000000000038631.
PTGES2 and RNASET2 identified as novel potential biomarkers and therapeutic targets for basal cell carcinoma: insights from proteome-wide mendelian randomization, colocalization, and MR-PheWAS analyses
Han QJ, Zhu YP, Sun J, Ding XY, Wang X, Zhang QZ.
Front Pharmacol. 2024 Jul 5;15:1418560. doi: 10.3389/fphar.2024.1418560.
Intestinal microbiota and tuberculosis: Insights from Mendelian randomization
Liu P, Luo Y, Zhang M.
Medicine (Baltimore). 2024 Jul 5;103(27):e38762. doi: 10.1097/MD.0000000000038762.
Plasma proteins and psoriatic arthritis: a proteome-wide Mendelian randomization study
Zhao H, Zhou Y, Wang Z, Zhang X, Chen L, Hong Z.
Front Immunol. 2024 Jul 4;15:1417564. doi: 10.3389/fimmu.2024.1417564.
Relationship between Sjogren's syndrome and gastroesophageal reflux: A bidirectional Mendelian randomization study
Liu J, Li J, Yuan G, Cao T, He X.
Sci Rep. 2024 Jul 4;14(1):15400. doi: 10.1038/s41598-024-65512-4.
Large-scale bidirectional Mendelian randomization study identifies new gut microbiome significantly associated with immune thrombocytopenic purpura
Li J, Li J, Liu Y, Zeng J, Liu Y, Wu Y.
Front Microbiol. 2024 Jul 4;15:1423951. doi: 10.3389/fmicb.2024.1423951.
Unraveling the relationship between gut microbiota and site-specific endometriosis: a Mendelian randomization analysis
Tang Y, Yang J, Hang F, Huang H, Jiang L.
Front Microbiol. 2024 Jul 4;15:1363080. doi: 10.3389/fmicb.2024.1363080.
A Systematic Review of Mendelian Randomization Studies on Celiac Disease
Omar M, Nassar S, Omar M, Naffaa ME, Lahat A, Sharif K.
medRxiv 2024.07.03.24309885; doi: https://doi.org/10.1101/2024.07.03.24309885
Is Type 2 Diabetes Mellitus Associated with Spinal Degenerative Disorders?: Evidence from Observational and 2-Sample Mendelian Randomization Analyses
Zou MX, Xia C, Wu PF, Hu HH, Zhu HX, Zheng BW, Jiang LX, Escobar D, Li J, Lü GH, Huang W, Zhang TL, Liu JH.
J Bone Joint Surg Am. 2024 Jul 3;106(13):1189-1196. doi: 10.2106/JBJS.23.00984.
Inflammatory factors and the risk of urolithiasis: a bidirectional Mendelian randomization study
Huang K, Peng Z, Zha C, Li W, Deng G, Chen X, Luo Y, Ji Z, Wang Q, Jiang K.
Front Med (Lausanne). 2024 Jul 3;11:1432275. doi: 10.3389/fmed.2024.1432275.
Dietary Factors and the Risk of Colorectal Cancer: A Mendelian Randomization Study
Li X, Pan S, Wang J, Chang Z, Xiong H, Ding K, Tang Q.
Nutr Cancer. 2024 Jul 2:1-12. doi: 10.1080/01635581.2024.2374042.
The impact of 25-hydroxyvitamin D and calcium on risk of age-related macular degeneration: a Mendelian randomization study
Dong XX, Chen DL, Miao YF, Li DL, Kai JY, Hu DN, Zhang XF, Carla L, Andrzej G, Pan CW.
Am J Clin Nutr. 2024 Jul 2:S0002-9165(24)00590-2. doi: 10.1016/j.ajcnut.2024.06.018.
Association between gut microbiota and malignant cardiac tumors: A two-sample Mendelian randomization study
Song Y, Hu J, Li C, Lian J.
Cancer Med. 2024 Jul;13(13):e7455. doi: 10.1002/cam4.7455.
Hypertension and iron deficiency anemia: Exploring genetic associations and causal inference
Cao R, Zhang JX, Chen Z, Sun Q, Bai YP, Zhang GG.
Nutr Metab Cardiovasc Dis. 2024 Jul 2:S0939-4753(24)00243-6. doi: 10.1016/j.numecd.2024.06.017.
Causality of genetically determined metabolites on susceptibility to prevalent urological cancers: a two-sample Mendelian randomization study and meta-analysis
Dai X, Wang H, Zhong R, Li J, Hou Y.
Front Genet. 2024 Jul 1;15:1398165. doi: 10.3389/fgene.2024.1398165.
Association of Crohn's disease and ulcerative colitis with the risk of neurological diseases: a large-scale Mendelian randomization study
Wang Y, Jia Y, Xu Q, Yang P, Sun L, Liu Y, Chang X, He Y, Shi M, Guo D, Zhang Y, Zhu Z.
J Hum Genet. 2024 Jul 1. doi: 10.1038/s10038-024-01271-4.
No causal relationship between serum urate and neurodegenerative diseases: A Mendelian randomization study
Wang M, Tang Z.
Exp Gerontol. 2024 Sep;194:112503. doi: 10.1016/j.exger.2024.112503.
Associations of modifiable factors with risk of irritable bowel syndrome
Chen Y, Yang H, Song J, Chen W, Liu K, Liu B, Luo P, Sun X, He Z, Mao Y, Ye D.
Front Nutr. 2024 Jul 1;11:1362615. doi: 10.3389/fnut.2024.1362615.
Causality of metabolites and metabolic pathways on cholestatic liver diseases: a Mendelian randomization study
Wei Z, Liu Y, Xiong Q, Mei X, Li J, Wu Z.
Front Med (Lausanne). 2024 Jul 2;11:1395526. doi: 10.3389/fmed.2024.1395526.
Differing genetic variants associated with liver fat and their contrasting relationships with cardiovascular diseases and cancer
Ahmed A, Cule M, Bell JD, Sattar N, Yaghootkar H.
J Hepatol. 2024 Jul 1:S0168-8278(24)02336-5. doi: 10.1016/j.jhep.2024.06.030.
Unraveling genetic threads: Identifying novel therapeutic targets for allergic rhinitis through Mendelian randomization
Huang X, Shen R, Zheng Z.
World Allergy Organ J. 2024 Jul 1;17(7):100927. doi: 10.1016/j.waojou.2024.100927.
The Role of Gut Microbiota in Thromboangiitis Obliterans: Cohort and Mendelian Randomization Study
Sheng C, Huang W, Liao M, Yang P.
Biomedicines. 2024 Jul 1;12(7):1459. doi: 10.3390/biomedicines12071459.

June

The Genetic Causal Association between Socio-economic Status, multiple psycho-emotional Disorders, obesity and Risk for Rotator Cuff Syndrome: A Two-sample Mendelian Randomization
Yankun jiang, Yanzhu Shen, Guoyuan Sun, Weiguo Wang, Qidong Zhang
Researchsquare, 30 June 2024, doi: 10.21203/rs.3.rs-4500251/v1
Impaired GK-GKRP interaction rather than direct GK activation worsens lipid profiles and contributes to long-term complications: a Mendelian randomization study
Wang K, Shi M, Luk AOY, Kong APS, Ma RCW, Li C, Chen L, Chow E, Chan JCN.
Cardiovasc Diabetol. 2024 Jun 29;23(1):228. doi: 10.1186/s12933-024-02321-z.
Associations between immune cell traits and autoimmune thyroid diseases: a bidirectional two-sample mendelian randomization study
Cao Z, Huang J, Long X.
Immunogenetics. 2024 Aug;76(4):219-231. doi: 10.1007/s00251-024-01345-9.
Decoding connections in the European population: serum uric acid, sex hormone-binding globulin, total testosterone, estradiol, and female infertility - advanced bidirectional and mediative Mendelian randomization
Tan Z, Shen J, Huang Y, Li J, Ding M, Sun A, Hong J, Yang Y, He S, Zhu X, Luo R.
Front Endocrinol (Lausanne). 2024 Jun 28;15:1398600. doi: 10.3389/fendo.2024.1398600.
Immune-mediated inflammatory diseases and periodontal disease: a bidirectional two-sample mendelian randomization study
Zhang R, Ma H, Wang D, Zhang H.
BMC Immunol. 2024 Jun 28;25(1):39. doi: 10.1186/s12865-024-00634-y.
The impact of educational attainment on mental health: A Causal Assessment from the UKB and FinnGen Cohorts
Jareebi MA, Alqassim AY.
Medicine (Baltimore). 2024 Jun 28;103(26):e38602. doi: 10.1097/MD.0000000000038602.
Causal role of immune cells on cervical cancer onset revealed by two-sample Mendelian randomization study
Zhao Z, Yan P, Zhang X, Yu X, Lv F, Gong M, Yang XA.
Sci Rep. 2024 Jun 28;14(1):14890. doi: 10.1038/s41598-024-65957-7.
Causal relationships exist between polycystic ovary syndrome and adverse pregnancy and perinatal outcomes: a Mendelian randomization study
Ma Y, Cai J, Liu LW, Wen T, Huang W, Hou W, Wei Z, Xu Y, Xu Y, Wang Y, Mai Q.
Front Endocrinol (Lausanne). 2024 Jun 28;15:1327849. doi: 10.3389/fendo.2024.1327849.
Diet and risk for acute tubulointerstitial nephritis
Yang Y, Yang W.
Medicine (Baltimore). 2024 Jun 28;103(26):e38443. doi: 10.1097/MD.0000000000038443.
Asthma and risk of adverse pregnancy outcomes: A Mendelian randomization study
Han X, Wu TQ, Bian Y, Chen L, Feng X.
Heliyon. 2024 Jun 28;10(13):e33857. doi: 10.1016/j.heliyon.2024.e33857.
Decoding the Impact of Lipid Metabolism on Osteoporosis: A Study on Phosphatidylcholine, Inflammatory Factors, and Immune Cells
Huihuang Ye, Shaohao Wu, Hongming Meng, Chun Chen, Zhibiao Bai
Researchsquare, 27 June 2024, doi: 10.21203/rs.3.rs-4490999/v1