Below you will find all the published and preprint scientific papers using FinnGen data.

2023

July

Leisure sedentary behaviour increases the risk of venous thromboembolism: a Mendelian randomisation study
Chen L, You G, Yang Z, Shen R, Zhang R, Zhu D, Wang L, Lin S, Lv L, Huang K.
BMC Cardiovasc Disord. 2023 Jul 18;23(1):362. doi: 10.1186/s12872-023-03395-5.
Causal association between body mass index and temporomandibular disorders: a bidirectional two-sample Mendelian randomization analysis
Chen X, Cheng Z, Xu J, Zhao Z, Jiang Q.
BMC Oral Health. 2023 Jul 18;23(1):499. doi: 10.1186/s12903-023-03179-5.
The causal relationship between Education Attainment and Rheumatic Diseases: A two-sample Mendelian randomization
Jiangzhen Xie, MengHui Mao, Bin Zhang, MingFeng Yang, HongZhi Wang
Researchsquare, 18 July 2023, doi:10.21203/rs.3.rs-3153722/v1
A causal effects of gut microbiota in the development of migraine
He Q, Wang W, Xiong Y, Tao C, Ma L, Ma J, You C; International Headache Genetics Consortium.
J Headache Pain. 2023 Jul 17;24(1):90. doi: 10.1186/s10194-023-01609-x.
A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertility
Li T, Shao W, Wang Y, Zhou R, Yun Z, He Y, Wu Y.
Sci Rep. 2023 Jul 15;13(1):11426. doi: 10.1038/s41598-023-38624-6.
Genome wide association study identifies 4 novel risk loci for small intestinal neuroendocrine tumors including a missense mutation in LGR5
Giri AK, Aavikko M, Wartiovaara L, Lemmetyinen T, Karjalainen J, Mehtonen J, Palin K, Välimäki N, Tamlander M, Saikkonen R, Karhu A, Morgunova E, Sun B, Runz H, Palta P, Luo S, Joensuu H, Mäkelä TP, Kostiainen I, Schalin-Jäntti C, FinnGen, Palotie A, Aaltonen LA, Ollila S, Daly MJ.
Gastroenterology. 2023 Jul 13:S0016-5085(23)04769-8. doi: 10.1053/j.gastro.2023.06.031.
The Association between Circulating Lipids and Female Infertility Risk: A Univariable and Multivariable Mendelian Randomization Analysis
Zhu X, Hong X, Wu J, Zhao F, Wang W, Huang L, Li J, Wang B.
Nutrients. 2023 Jul 13;15(14):3130. doi: 10.3390/nu15143130.
Effect of bilirubin and Gilbert syndrome on health: cohort analysis of observational, genetic, and Mendelian randomisation associations
Hamilton FW, Abeysekera K, Hamilton W, Timpson NJ.
BMJ Med. 2023 Jul 12;2(1):e000467. doi: 10.1136/bmjmed-2022-000467.
Evidence for a causal relationship between psoriasis and cutaneous melanoma: a bidirectional two-sample Mendelian randomized study
Zhao N, Guo P, Tang M, Yang F, Zhang T, Mao R
Front Immunol. 2023 Jul 12;14:1201167. doi: 10.3389/fimmu.2023.1201167
The causal associations between growth factors and constipation: a two-sample Mendelian randomization study
Wang J, Yang M, Xu K, Wan X, Xie J, Yu H, Fang J, Wang Z, Xu P.
Front Physiol. 2023 Jul 12;14:1204146. doi: 10.3389/fphys.2023.1204146.
Evaluation of the effect of sodium-glucose cotransporter 2 inhibition on fracture risk: evidence from Mendelian randomization and genetic association study
Dai H, Zheng L, Zhu Z, Geng X, Hou T, Wang Q, Zhu Y, Lin H, Wang S, Zheng R, Zhao Z, Li M, Lu J, Xu Y, Wang T, Liu J, Ning G, Wang W, Bi Y, Zheng J, Xu M.
J Bone Miner Res. 2023 Jul 12. doi: 10.1002/jbmr.4880.
Causal relationship between kidney stones and gut microbiota contributes to the gut-kidney axis: a two-sample Mendelian randomization study
Liu M, Zhang Y, Wu J, Gao M, Zhu Z, Chen H.
Front Microbiol. 2023 Jul 12;14:1204311. doi: 10.3389/fmicb.2023.1204311.
Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure
Rasooly D, Peloso GM, Pereira AC, Dashti H, Giambartolomei C, Wheeler E, Aung N, Ferolito BR, Pietzner M, Farber-Eger EH, Wells QS, Kosik NM, Gaziano L, Posner DC, Bento AP, Hui Q, Liu C, Aragam K, Wang Z, Charest B, Huffman JE, Wilson PWF, Phillips LS, Whittaker J, Munroe PB, Petersen SE, Cho K, Leach AR, Magariños MP, Gaziano JM; VA Million Veteran Program; Langenberg C, Sun YV, Joseph J, Casas JP.
Nat Commun. 2023 Jul 10;14(1):3826. doi: 10.1038/s41467-023-39253-3.
Integrated multiple-microarray analysis and mendelian randomization to identify novel targets involved in diabetic nephropathy
Fan C, Gao Y, Sun Y.
Front Endocrinol (Lausanne). 2023 Jul 10;14:1191768. doi: 10.3389/fendo.2023.1191768.
Causal Associations Between Ankylosing Spondylitis and 36 Common Mental Disorders: A Two-Sample Mendelian Randomization Study
Jiachen Wang, Mingyi Yang, Ke Xu, Pan Luo, Ruoyang Feng, Xianjie Wan, Jiale Xie, Hui Yu, Peng Xu
Researchsquare, 10 July 2023, doi: 10.21203/rs.3.rs-3116275/v1
Genetically predicted the causal relationship between gut microbiota and infertility: bidirectional Mendelian randomization analysis in the framework of predictive, preventive, and personalized medicine
Xi Y, Zhang C, Feng Y, Zhao S, Zhang Y, Duan G, Wang W, Wang J.
EPMA J. 2023 Jul 7;14(3):405-416. doi: 10.1007/s13167-023-00332-6
A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease
Patel AP, Wang M, Ruan Y, Koyama S, Clarke SL, Yang X, Tcheandjieu C, Agrawal S, Fahed AC, Ellinor PT, Genes & Health Research Team; the Million Veteran Program, Tsao PS, Sun YV, Cho K, Wilson PWF, Assimes TL, van Heel DA, Butterworth AS, Aragam KG, Natarajan P & Khera AV.
Nat Med 29, 1793–1803 (2023). https://doi.org/10.1038/s41591-023-02429-x
Response to Li and Hopper
Mars N, Lindbohm JV, Della Briotta Parolo P, Widén E, Kaprio J, Palotie A; FinnGen; Ripatti S.
Am J Hum Genet. 2023 Jul 6;110(7):1224-1225. doi: 10.1016/j.ajhg.2023.05.016.
Maternal hypertensive traits and adverse outcome in pregnancy: a Mendelian randomization study
Ardissino M, Reddy RK, Slob EAW, Griffiths J, Girling J, Ng FS.
J Hypertens. 2023 Jul 6. doi: 10.1097/HJH.0000000000003486.
Causal impacts of educational attainment on chronic liver diseases and the mediating pathways: Mendelian randomization study
Wang Y, Kong L, Ye C, Dou C, Zheng J, Xu M, Xu Y, Li M, Zhao Z, Lu J, Chen Y, Wang W, Ning G, Bi Y, Wang T.
Liver Int. 2023 Jul 6. doi: 10.1111/liv.15669.
Associations between attention-deficit/hyperactivity disorder and allergic diseases: a two-sample Mendelian randomization study
Zhang X, Zhang R, Zhang Y, Lu T.
Front Psychiatry. 2023 Jul 5;14:1185088. doi: 10.3389/fpsyt.2023.1185088.
The effects of unsaturated fatty acids on psoriasis: A two-sample Mendelian randomization study
Lei H, Chen X, Cheng B, Song L, Luo R, Wang S, Kang T, Wang Q, Zheng Y
Food Sci Nutr. 2023 Jul 5;11(10):6073-6084. doi: 10.1002/fsn3.3543
Assessing the genetic relationship between gastroesophageal reflux disease and chronic respiratory diseases: a mendelian randomization study
Cheng X, Shi J, Zhang D, Li C, Xu H, He J, Liang W.
BMC Pulm Med. 2023 Jul 4;23(1):243. doi: 10.1186/s12890-023-02502-8.
Coffee intake and risk of diabetic nephropathy: a Mendelian randomization study
Fang J, Song K, Zhang D, Liang Y, Zhao H, Jin J, He Q.
Front Endocrinol (Lausanne). 2023 Jul 4;14:1169933. doi: 10.3389/fendo.2023.1169933.
Association of iron homeostasis biomarkers in type 2 diabetes and glycaemic traits: a bidirectional two-sample Mendelian randomization study
Liang Y, Luo S, Wong THT, He B, Schooling CM, Au Yeung SL.
Int J Epidemiol. 2023 Jul 3:dyad093. doi: 10.1093/ije/dyad093.
Causal association between inflammatory bowel disease and herpes virus infections: a two-sample bidirectional Mendelian randomization study
Zou M, Zhang W, Shen L, Xu Y, Zhu Y.
Front Immunol. 2023 Jul 3;14:1203707. doi: 10.3389/fimmu.2023.1203707.
Genetic evidence for the causal linkage between telomere length and aortic aneurysm risk: A Mendelian randomisation study
Zhang R, Wu M, Ma M, Liu B, Zhang X, Wei N, Wang T, Lv Y, Xu C, Wang J, Zhang Y, Liu F.
Eur J Clin Invest. 2023 Jul 1:e14056. doi: 10.1111/eci.14056.

June

Associations between vitamin D and autoimmune diseases: Mendelian randomization analysis
Zhao SS, Mason A, Gjekmarkaj E, Yanaoka H, Burgess S.
Seminars in Arthritis and Rheumatism, 2023, 152238, ISSN 0049-0172, https://doi.org/10.1016/j.semarthrit.2023.152238.
Association between appendicular lean mass and chronic obstructive pulmonary disease: epidemiological cross-sectional study and bidirectional Mendelian randomization analysis
Fu C, Yang H.
Front Nutr. 2023 Jun 29;10:1159949. doi: 10.3389/fnut.2023.1159949.
Causal Associations Between Dietary Habits and Cardiovascular Disease: A Mendelian Randomization Study
Yang M, Gao X, Xie L, Lin Z, Ye X, Ou J, Peng J.
Br J Nutr. 2023 Jun 29:1-21. doi: 10.1017/S000711452300140X.
topr: an R package for viewing and annotating genetic association results.
Juliusdottir T.
BMC Bioinformatics. 2023 Jun 28;24(1):268. doi: 10.1186/s12859-023-05301-4.
An exploration of the correlations between seven psychiatric disorders and the risks of breast cancer, breast benign tumors and breast inflammatory diseases: Mendelian randomization analyses
Ren F, Shang Q, Zhao S, Yang C, Feng K, Liu J, Kang X, Zhang R, Wang X, Wang X.
Front Psychiatry. 2023 Jun 28;14:1179562. doi: 10.3389/fpsyt.2023.1179562.
Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study
Zhang H, Yuan S, Li Y, Li D, Yu Z, Hu L, Li X, Wang Y, Larsson SC.
Front Med (Lausanne). 2023 Jun 27;10:1180596. doi: 10.3389/fmed.2023.1180596.
Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry)
Viippola E, Kuitunen S, Rodosthenous RS, Vabalas A, Hartonen T, Vartiainen P, Demmler J, Vuorinen AL, Liu A, Havulinna AS, Llorens V, Detrois KE, Wang F, Ferro M, Karvanen A, German J, Jukarainen S, Gracia-Tabuenca J, Hiekkalinna T, Koskelainen S, Kiiskinen T, Lahtela E, Lemmelä S, Paajanen T, Siirtola H, Reeve MP, Kristiansson K, Brunfeldt M, Aavikko M, Gen F, Perola M, Ganna A; FinnGen.
Int J Epidemiol. 2023 Jun 26:dyad091. doi: 10.1093/ije/dyad091.
The Causal Effects of Cholelithiasis on Acute Pancreatitis and Pancreatic Cancer: A Large Sample Size Mendelian Randomization Analysis
Rao M, Ai X, Huang Z.
Recent Pat Anticancer Drug Discov. 2023 Jun 26. doi: 10.2174/1574892818666230609121409.
A Mendelian Randomization Study on the Causal Relationship between Blood Lipids and Lung Cancer
LN Ding, CJ Lei, QW Lei, HC Ma, ZZ Xiao, X Zhang, XM Mo, HB Zhang
Researchsquare, 26 June 2023, [https://doi.org/10.21203/rs.3.rs-3066618/v1]
Neuropsychiatric disorders as risk factors and consequences of COVID-19: A Mendelian randomization study
Xiang Y, Qiu J, Zhang R, Chau CK-L, Rao S, So H-C.
medRxiv 2021.06.29.21259609; doi: https://doi.org/10.1101/2021.06.29.21259609
Circulating inflammatory cytokines and female reproductive diseases: a Mendelian randomization analysis
Lin Y, Wang G, Li Y, Yang H, Zhao Y, Liu J, Mu L.
J Clin Endocrinol Metab. 2023 Jun 23:dgad376. doi: 10.1210/clinem/dgad376.
Prioritization of nasal polyp-associated genes by integrating GWAS and eQTL summary data
Yoshikawa M, Asaba K, Nakayama T.
Front Genet. 2023 Jun 23;14:1195213. doi: 10.3389/fgene.2023.1195213.
Association between gut microbiota and primary ovarian insufficiency: a bidirectional two-sample Mendelian randomization study
Wang J, Luo R, Zhao X, Xia D, Liu Y, Shen T, Liang Y.
Front Endocrinol (Lausanne). 2023 Jun 22;14:1183219. doi: 10.3389/fendo.2023.1183219.
Gut microbiota and atopic dermatitis: a two-sample Mendelian randomization study
Xue Y, Zhang L, Chen Y, Wang H, Xie J.
Front Med (Lausanne). 2023 Jun 22;10:1174331. doi: 10.3389/fmed.2023.1174331.
The relationship between blood lipid and risk of psoriasis: univariable and multivariable Mendelian randomization analysis
Zhang ZY, Jian ZY, Tang Y, Li W.
Front Immunol. 2023 Jun 22;14:1174998. doi: 10.3389/fimmu.2023.1174998.
Causal relationship between gastro-esophageal reflux disease and risk of lung cancer: insights from multivariable Mendelian randomization and mediation analysis
Liu Y, Lai H, Zhang R, Xia L, Liu L.
Int J Epidemiol. 2023 Oct 5;52(5):1435-1447. doi: 10.1093/ije/dyad090.
The genetic associations of COVID-19 on genitourinary symptoms
Chang Z, An L, Lei M, Song Z, Deng J, Tang R, Cheng ZJ, Wu W, Sun B.
Front Immunol. 2023 Jun 21;14:1216211. doi: 10.3389/fimmu.2023.1216211.
Gut microbiota and chronic obstructive pulmonary disease: a Mendelian randomization study
Wei Y, Lu X, Liu C.
Front Microbiol. 2023 Jun 19;14:1196751. doi: 10.3389/fmicb.2023.1196751.
Multi-ancestry meta-analysis identifies 5 novel loci for ischemic stroke and reveals heterogeneity of effects between sexes and ancestries
Surakka I, Wu K-HH, Hornsby WE, Wolford B, Shen F, Zhou W, Huffman JE, Pandit A, Hu Y, Brumpton B, Skogholt AH, Gabrielsen ME, Walters R, The TOPMed Stroke Working Group, Million Veteran Program (MVP), Hveem K, Kooperberg C, Zollner S, Wilson PWF, Sutton NR, Daly M, Neale B, Willer CJ, Global Biobank Meta-analysis Initiative (GBMI).
Cell Genomics, 2023, 100345, ISSN 2666-979X, https://doi.org/10.1016/j.xgen.2023.100345.
Major depressive disorder plays a vital role in the pathway from gastroesophageal reflux disease to chronic obstructive pulmonary disease: a Mendelian randomization study
Zou M, Zhang W, Shen L, Xu Y, Zhu Y.
Front Genet. 2023 Jun 19;14:1198476. doi: 10.3389/fgene.2023.1198476.
The Causal Associations Between Juvenile Idiopathic Arthritis and 15 Mental Disorders: A Two-Sample Mendelian Randomization Study
Jiachen Wang, Mingyi Yang, Ke Xu, Pan Luo, Ruoyang Feng, Xianjie Wan, Jiale Xie, Hui Yu, Peng Xu
Researchsquare, 15 June 2023, doi:10.21203/rs.3.rs-3027630/v1
Multi-layered genetic approaches to identify approved drug targets
Sadler MC, Auwerx C, Deelen P, Kutalik Z.
Cell Genomics, 2023, 100341, ISSN 2666-979X, https://doi.org/10.1016/j.xgen.2023.100341.
Mendelian randomization indicates that atopic dermatitis contributes to the occurrence of diabetes
Lu F, Wu B, Wang Y.
BMC Med Genomics. 2023 Jun 15;16(1):132. doi: 10.1186/s12920-023-01575-y.