Tältä sivulta löydät kaikki FinnGen-aineistoa hyödyntäneet julkaisut ja preprint-artikkelit.
2025

Lokakuu

Risk factors for arterial stiffness in a multi-ethnic Asian population: Results from the Health for Life in Singapore Study
Sanikini H, Mina T, Tsilidis K K, The HELIOS Study Team, Ngeow J, Lee E S, Lee J, Elliott P, Chambers J, Riboli E.
medRxiv 2025.10.10.25337779; doi: https://doi.org/10.1101/2025.10.10.25337779
Revisiting the effects of physical activity on anxiety and mediation from plasma proteins: triangulation of evidence from observational study, Mendelian randomization, mediation and meta-analysis
Chen Y, Wen J, Liu A, Wen SW, Zhou J.
J Affect Disord . 2025 Oct 11:120422. doi: 10.1016/j.jad.2025.120422.
Unraveling the causality between carpal tunnel syndrome and trigger finger through genetic instrumental variables
Junming Huang, Kui Deng, Shanhu Huang, Zhengtao Lv, Song Zhou, Mingxing Chen
Eur J Med Res 30, 963 (2025). https://doi.org/10.1186/s40001-025-02833-8
Bidirectional Association and Genetic Background of Anxiety Disorders and General Medical Conditions
Tervi A, Suomalainen E, Heidi Perälampi H, Frilander N, Naamanka J, FinnGen, Anxiety Disorders Working Group of the Psychiatric Genomics Consortium, Suvisaari J, Elovainio M, Hovatta I.
medRxiv 2025.10.10.25337730; doi: https://doi.org/10.1101/2025.10.10.25337730
Identifying the causal role and therapeutic potential of immune-related genes in bladder cancer: a Mendelian randomization study
Chen Y, Yu Q, Jiang X, Li L, Kang L.
Discov Oncol . 2025 Oct 13;16(1):1857. doi: 10.1007/s12672-025-03806-3.
Single-cell RNA sequencing and Mendelian randomization, revealing molecular mechanisms and causal correlation of immune-related genes in periodontitis
Xuedi Qiu, Fan Yang, Chenxi Li, Jian Wang, Yawen Yuan, Chao Guo
Sci Rep 15, 35686 (2025). https://doi.org/10.1038/s41598-025-19438-0
Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease
Howard C, Abell N, Warneford-Thomson R, Mahdavi E, Su A, Resnick C, Mohammed N, Thompson E, Holzinger E, Catalano K, Hukku A, Mintier G, Wilson S, Maranville J, Sheth P, Plenge R, Kosuri S, Dickel D.
bioRxiv 2025.10.11.681520; doi: https://doi.org/10.1101/2025.10.11.681520
Genetic variants associated with gout identified through a genome-wide study in the UK biobank (N = 150 542)
Tao Y, Cai T, Pan Q, Yang L, Lin S, Haque M, Dottorini T, Abhishek A, Meng W.
Hum Mol Genet . 2025 Oct 11:ddaf151. doi: 10.1093/hmg/ddaf151.
Insights into causal associations between type 2 diabetes and common human diseases: a phenotype-wide bi-directional Mendelian randomization analysis
Sun W, Cao H, Liu D, Baranova A, Zhang X, Zhang F.
Nutr Metab Cardiovasc Dis . 2025 Sep 24:104371. doi: 10.1016/j.numecd.2025.104371.
Glutaryl-CoA dehydrogenase (GCDH) enhances renal malignancy risk via modulating glutarylcarnitine levels
Liu X, Chen B, Yuan J, Li S, Gao L, Chu M, Fan S, Fan W.
Discov Oncol . 2025 Oct 10;16(1):1852. doi: 10.1007/s12672-025-03700-y.
Multimodal AI for Precision Preventive Cardiology
Pandey D, Xu L, Kun E, Li C, Wang J Y, Melek A, DiCarlo J C, Castillo E, Narula J, Taylor C A, Narasimhan V M.
medRxiv 2025.10.09.25337677; doi: https://doi.org/10.1101/2025.10.09.25337677
Systematic genetic investigation on relative macronutrient intake, circulating metabolic biomarkers and the risk of autoimmune diseases
Shengzhang Zheng, Guanqiong Na, Kailin Liang, Danqun Meng, Yujuan Shan, Dazhi Chen
npj Sci Food 9, 205 (2025). https://doi.org/10.1038/s41538-025-00565-x
Causal effects of sleep behaviors on temporomandibular disorders and pain: a bidirectional mendelian randomization study
Zhang Y, Ozathaley A, Wang X, Wu Y, Zhang K, Li Y, Nuerlan G, Li Q, Mao J, Li H, Gong S.
J Oral Facial Pain Headache . 2025 Jun;39(2):101-111. doi: 10.22514/jofph.2025.029.
SLC45A4 is a pain gene encoding a neuronal polyamine transporter
Middleton SJ, Markússon S, Åkerlund M, Deme JC, Tseng M, Li W, Zuberi SR, Kuteyi G, Sarkies P, Baskozos G, Perez-Sanchez J, Hébert HL, Toikumo S, Farah A, Maxwell S, Dong YY, Kranzler HR, Linley JE, Smith BH, Lea SM, Parker JL, Lyssenko V, Newstead S, Bennett DL.
Nature 646, 404–412 (2025). https://doi.org/10.1038/s41586-025-09326-y
Exploring potential target drugs for vision-threatening diabetic retinopathy using the human plasma proteome: a Mendelian randomisation study
Yanhua Liang, Yu Huang, Xiayin Zhang, Zijing Du, Yaxin Wang, Honghua Yu, Yijun Hu
BMJ Open 2025;15:e094669. doi: 10.1136/bmjopen-2024-094669
Genetically Prioritized Plasma Proteins as Candidate Therapeutic Targets for Dry Age-Related Macular Degeneration
Hou J, Guo J, Shen W, Xie D, Li P, Zhang Y, Zhao Z.
J Ophthalmol . 2025 Sep 30:2025:3972293. doi: 10.1155/joph/3972293.
Thyroid disease and breast cancer, benign breast neoplasm: a two-sample Mendelian randomization study
Bowen Wang, Yue Ling, Hui Zhang, Yang Liu, Jiacheng Yuan, Yinuo Zhang, Ming Yang
BMC Women's Health 25, 481 (2025). https://doi.org/10.1186/s12905-025-04046-x
Integrating genomics and metabolomics to reveal the genetic basis and potential therapeutic targets of diabetic foot
Zhang Y, Chen C, Li ZD, Zhou HC, Li B, Yang YF.
Zhongguo Gu Shang . 2025 Sep 25;38(9):891-901. doi: 10.12200/j.issn.1003-0034.20241216.
New evidence for the protective effect of gut microbiota regulation of ferroptosis-related proteins against osteoporosis
Guo Z, Di J, Qin Y, Wang X, Tian Z, Long Y, Wang Y, Xiang C.
World J Microbiol Biotechnol . 2025 Oct 9;41(10):368. doi: 10.1007/s11274-025-04590-6.
Antihypertensive Drugs and Dental Caries Risk: A Drug-Target Mendelian Randomization Analysis
Shi W, Liu S, Wu X, Cheng W, Jia X, Hu Z.
Int J Genomics . 2025 Oct 7:2025:1612322. doi: 10.1155/ijog/1612322. eCollection 2025.
Genome-wide association study provides insights into the genetic basis of Lewy body dementia
Ping Zhu, Zhengxin Jin, Shiyang Wu, Shan Gao, Yijie He, Shuyuan Hu, Fengzhen Liu, Yan Chen, Mingxin Wang, Kun Wang, Guiyou Liu
Mol Psychiatry 30, 5813–5827 (2025). https://doi.org/10.1038/s41380-025-03295-4
Causal relationships between monocyte chemoattractant protein-1 levels and neuropsychiatric disorders: Evidence from large-scale genetic data
He Y, Hu W, Li Y, Han Z.
J Neuroimmunol . 2025 Oct 4:409:578767. doi: 10.1016/j.jneuroim.2025.578767.
Causal Relationship Between Brain Functional Networks and Sleep Disorders: A Mendelian Randomization Study
Lin W, Chen X, Wei Y, Yang L, Li H, Zhu T.
Brain Behav . 2025 Oct;15(10):e70870. doi: 10.1002/brb3.70870.
Characterization of prevalent genetic variants in the Estonian Biobank body-mass index GWAS
Erik Abner, Kanwal Batool, Nele Taba, Tiit Nikopensius, Kristi Läll, Anastasiia Alekseienko, Anders Eriksson, Joel Rämö, Hele Haapaniemi, Hanna Maria Kariis, Liis Haljasmägi, Urmo Võsa, Taavi Tillmann, Uku Vainik, Kelli Lehto, Hanna M. Ollila, Kai Kisand, Estonian Biobank Research Team, Tõnu Esko
Nat Commun 16, 8956 (2025). https://doi.org/10.1038/s41467-025-64006-9
Potential drug targets for intracranial aneurysms identified through Mendelian randomization analysis
Peng L, Peng H, Wu N, Wang X, Han L, Ding X.
Neurosurg Rev . 2025 Oct 8;48(1):683. doi: 10.1007/s10143-025-03870-x.
Exploring the shared genetic architecture between leukocyte telomere length and renal cell carcinoma: a cross-trait analysis
Li Wang, Jian-wei Yang, Kang-yu Wang, Si-yu Chen, Li Yang
Discov Onc 16, 1826 (2025). https://doi.org/10.1007/s12672-025-03565-1
Unveiling the therapeutic potential of senescence-related IQGAP2 in pancreatic Cancer through post-GWAS genomic and scRNA-seq analyses
Zilong Bai, Jiale Liang, Yuanhua Nie, Shilong Wang, Dongmin Chang
Discov Onc 16, 1301 (2025). https://doi.org/10.1007/s12672-025-03078-x
Genetic variants of glucose-dependent insulinotropic polypeptide (GIP) signalling as proxy for body weight reduction and cardiovascular risk
Emanuelsson F, Nordestgaard BG, Benn M.
Eur Heart J . 2025 Oct 7:ehaf779. doi: 10.1093/eurheartj/ehaf779.
Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer’s Disease Risk Prediction in Multiethnic Cohorts
Okorie M, Jonson C, Oddi A P, Castruita P A, Fulton-Howard B, Yaffe K, Yokoyama J S, Udeh-Momoh C, Andrews S J, the Alzheimer’s Disease Sequencing Project and the Healthy Aging Brain Study - Health Disparities
medRxiv 2025.10.03.25337285; doi: https://doi.org/10.1101/2025.10.03.25337285
Genome-wide meta-analyses of cross substance use disorders in diverse populations
Dongbing Lai, Michael Zhang, Nick Green, Marco Abreu, Tae-Hwi Schwantes-An, Clarissa C. Parker, Shanshan Zhang, Fulai Jin, Anna Sun, Pengyue Zhang, Howard J. Edenberg, Yunlong Liu, Tatiana Foroud
Mol Psychiatry (2025). https://doi.org/10.1038/s41380-025-03294-5
Effect of a Dietary Intervention on Weight Loss in Adults with High vs Low Genetic Predisposition to Higher BMI: A Randomized Diet Intervention Trial
Rodosthenous S, Viiri L E, Carson A, Cajuso T, Corbetta A, Jones S, Brenna E, FinnGen, Makkonen E, Virolainen M, Korkeala N, Widén E, Ripatti S, Ganna A.
medRxiv 2025.10.06.25337395; doi: https://doi.org/10.1101/2025.10.06.25337395
Identification of genetically-supported new drug targets for osteomyelitis based on druggable genomes
Yao R, Lu Y, Lu D, Ren H, Wang X, Lin B, Chen S, Zhu Y, Chen F, Wang Y, Gao Y, Shen J, Guo Q, Huang K.
Hum Genomics . 2025 Oct 7;19(1):117. doi: 10.1186/s40246-025-00826-6.
Sex hormones and meningiomas risk: a Mendelian randomization and immunohistochemical analysis
Chen F, Zhang J, Hou X, Li T, Xu Z, Li S, Zhou Y, Wang Y, Wang W, Liu P, Liu M
Researchsquare, 07 October 2025, doi: 10.21203/rs.3.rs-7564859/v1
Using Genetics to Understand Shared Mechanisms Between Hypertension and Type 2 Diabetes Accounting for Adiposity
Voller B, Woodward R, Gu Q, Murrin O, Delgado J, Violán C, Khalid S, Türkmen D, Fox C, Lamb S, Mancini M, Farmer L, Boddy K, Dudbridge F, Bowden J, Frayling T M, Masoli J, Pilling L C, he GEMINI Consortium
medRxiv 2025.10.03.25337275; doi: https://doi.org/10.1101/2025.10.03.25337275
Integrated multi-omics profiling reveals shared mechanistic pathways in asthma-allergic rhinitis comorbidity: A hybrid machine learning framework leveraging Mendelian randomization for precision diagnostics
Wang H, Tu J, Zhang J, Wang W, Yuan Z, Li C, Wang Y.
World Allergy Organ J . 2025 Sep 22;18(10):101120. doi: 10.1016/j.waojou.2025.101120. eCollection 2025 Oct.
Genetic underpinnings of the heterogeneous impact of obesity on lipid levels and cardiovascular disease
Daeeun Kim, Heather M. Highland, Roelof A. J. Smit, Micah R. Hysong, Victoria L. Buchanan, Kristin L. Young, Chi Zhao, Cassandra N. Spracklen, Tuomas O. Kilpeläinen, Boya Guo, Burcu F. Darst, Yanwei Cai, Zhe Wang, Jessica Lundin, Sonja I. Berndt, JoAnn E. Manson, Eirini Marouli, Leslie Lange, Ethan Lange, Myriam Fornage, Christopher R. Gignoux, Christopher A. Haiman, Stephen S. Rich, Steven Buyske, Ruth J. F. Loos, Charles Kooperberg, Ulrike Peters, Christy L. Avery, Penny Gordon-Larsen, Mariaelisa Graff, Laura M. Raffield, Kari E. North
Genome Med 17, 113 (2025). https://doi.org/10.1186/s13073-025-01522-9
Identification of C4BPA as a genetically informed drug target in NSCLC: an integrative single-cell and multi-omics study based on the druggable genes
Zhihan Xiao, Xinji Liu, Wei Tang, Yan Lv, Tongyu Zhang, Xu Zhan, Qihang Sun, Willis Wasonga Omindo, Qi Wang, Ruijie Zhang, Wei Ping, Ni Zhang
Hum Genomics 19, 113 (2025). https://doi.org/10.1186/s40246-025-00829-3
Plasma Proteome Profiling Identifies Biomarkers and Potential Drug Targets for Non-Small Cell Lung Cancer
Zhao M, Di X, Zhao Y.
Int J Med Sci . 2025 Sep 12;22(15):4036-4048. doi: 10.7150/ijms.107109. eCollection 2025.
Mediating Effects of Plasma Metabolites in Inflammatory Protein-Lymphoma Causality: A Mendelian Randomization Study
Ji Y, Gao X, Liu L, Wan Z, Qin W.
Curr Med Chem. 2025 Oct 2. doi: 10.2174/0109298673382735250904071151.
Identification of Plasma Protein Biomarkers and Drug Targets for Hematologic Malignancies by Proteome-wide Mendelian Randomization
Pan T, Zhang J, Wang X, Song Y.
J Cancer . 2025 Sep 3;16(13):3917-3927. doi: 10.7150/jca.115044. eCollection 2025.
Association Between Specific Sleep Traits and Four Inflammatory Skin Diseases: A Mendelian Randomization Study
Yang P, Huang Y, He W, Chen T, Wei S, Zhao Y.
Clin Cosmet Investig Dermatol . 2025 Sep 29:18:2509-2521. doi: 10.2147/CCID.S541688. eCollection 2025.
Genetic evidence for the correlation between relative nutrient intake and male reproductive health: a Mendelian randomized study
Li S, Wang S, Jing Z, Guo J, Cao X, Guo Q.
Aging Male. 2025 Dec;28(1):2568142. doi: 10.1080/13685538.2025.2568142.
The relationship between gut microbiota, plasma metabolites, and iron deficiency anemia in European populations: a three-sample Mendelian randomization analysis
Zheng X, Shen W, Yin J.
Hematology. 2025 Dec;30(1):2549962. doi: 10.1080/16078454.2025.2549962.
Triangulation evidence for the causal effect of monocytes on pulmonary artery hypertension: a Mendelian randomization study and results from NHANES
Liu Z, Fu Q, Shao Y, Cao J.
Respir Med. 2025 Oct 1:108388. doi: 10.1016/j.rmed.2025.108388.
A genetic map of human metabolism across the allele frequency spectrum
Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M, Williamson A, Pietzner M, Langenberg CC.
Nat Genet (2025). https://doi.org/10.1038/s41588-025-02355-3
Meta-analysis of exome-wide gene burden analysis of breast cancer susceptibility genes
Jennifer A. Collister, Karl Smith-Byrne, Joshua Atkins, Gillian Reeves, David J. Hunter
npj Breast Cancer 11, 111 (2025). https://doi.org/10.1038/s41523-025-00826-8
Circulating vitamin D concentrations and the risk of urticaria: A bidirectional two-sample Mendelian randomization study
Chai HX, Wang F, Liu H, Xie YQ, Zhou ZH.
Asia Pac J Clin Nutr . 2025 Oct;34(5):740-749. doi: 10.6133/apjcn.202510_34(5).0004.
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus
Krista Freimann, Anneke Brümmer, Robert Warmerdam, Tarran S. Rupall, Ana Laura Hernández-Ledesma, Joshua Chiou, Emily R. Holzinger, Joseph C. Maranville, Nikolina Nakic, Halit Ongen, Luca Stefanucci, Michael C. Turchin, eQTLGen Consortium, Lude Franke, Urmo Võsa, Carla P. Jones, Alejandra Medina-Rivera, Gosia Trynka, Kai Kisand, Sven Bergmann, Kaur Alasoo
Nat Commun 16, 8795 (2025). https://doi.org/10.1038/s41467-025-63856-7
Dietary factors mediated the causal association between educational attainment and chronic periodontitis: A 2-sample Mendelian randomization study
Jiang L, Li S, Huang S, Liu B, Reissmann DR, Schmalz G, Hu X.
Medicine (Baltimore) . 2025 Sep 26;104(39):e44620. doi: 10.1097/MD.0000000000044620.
Genetic evidence for the effect of prepregnancy maternal metabolic status on the risk of congenital heart disease in offspring: A Mendelian randomization study
Sağlam E, Özler MR.
Medicine (Baltimore) . 2025 Sep 26;104(39):e44820. doi: 10.1097/MD.0000000000044820.