Below you will find all the published and preprint scientific papers using FinnGen data.

2025

April

Impact of anti-VZV IgG levels on Parkinson’s disease risk and progression: a Mendelian randomization analysis
Sun J, Li X, Ma S, Lin H, Li Z, Jia J, Alizadeh Y, Wu Q, Hou Y, Wang H, Wang Q, Zhang G, Li X, Li W, Zhang C.
Sci Rep. 2025 Apr 8;15(1):11985. doi: 10.1038/s41598-025-96382-z.
Hyperglycemia as driver of glioblastoma progression: Insights from Mendelian randomization and single-cell transcriptomics
Li J, Wu W, Ye L, Zheng B.
Brain Res. 2025 Apr 8;1858:149636. doi: 10.1016/j.brainres.2025.149636.
Causal relationship between breast cancer and acute myeloid leukemia based on two-sample bidirectional Mendelian randomization and transcriptome overlap analysis
Pan X, Huang C, Bai X, Li F.
Discov Oncol. 2025 Apr 8;16(1):492. doi: 10.1007/s12672-025-02288-7.
Investigating sex-specific associations of Parkinson's disease with sex hormones and sex hormones-related phenotypes using Mendelian randomization
Liu S, Hu Y, Liu J, Luo Y, Li T, Liu Z, Xu Q, Sun Q, Yan X, Li J, Tang B, Tan Z, Guo J.
Parkinsonism Relat Disord. 2025 Apr 8;135:107831. doi: 10.1016/j.parkreldis.2025.107831.
A causal effects of neutrophil extracellular traps and its biomarkers on acute respiratory distress syndrome: a two-sample Mendelian randomization study
Chen Y, Mao R, Chang Q, Yuan Y, Zhang H, Li F.
Sci Rep. 2025 Apr 8;15(1):11995. doi: 10.1038/s41598-025-95676-6.
Exploration of the multiomics-based mechanisms of Gancao Nourishing-Yin decoction in regulating mitochondrial metabolic genes CYB5R3 and PICK1 to influence glioma progression
Chen Y, Zhang A, Lei L, Xiao K, Mao W.
Discov Oncol. 2025 Apr 8;16(1):487. doi: 10.1007/s12672-025-02168-0.
Causal relationships between hundreds of plasma metabolites and PTSD: a bidirectional mendelian randomization study
Yao X, Hu J, Zhang X, Hu J.
BMC Psychiatry. 2025 Apr 8;25(1):349. doi: 10.1186/s12888-025-06796-2.
Association of MTHFR missense variants with thromboembolic diseases and coagulation factor levels in European populations
Daghlas I, Wang M, Gill D.
Thromb J. 2025 Apr 8;23(1):29. doi: 10.1186/s12959-025-00711-1.
Ulcerative colitis increases the risk of atrioventricular block: evidence from a Mendelian randomized analysis
Shu W, Huang G.
Sci Rep. 2025 Apr 7;15(1):11873. doi: 10.1038/s41598-025-96111-6.
Elucidating Causal Relationships Among Gut Microbiota, Human Blood Metabolites, and Knee Osteoarthritis: Evidence from a Two-Stage Mendelian Randomization Analysis
Wang Z, Zhao C, Wang Z, Li M, Zhang L, Diao J, Chen J, Zhang L, Wang Y, Li M, Zhou Y, Xu H.
Rejuvenation Res. 2025 Apr 7. doi: 10.1089/rej.2024.0079.
Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum
Lee DSM, Cardone KM, Zhang DY, Tsao NL, Abramowitz S, Sharma P, DePaolo JS, Conery M, Aragam KG, Biddinger K, Dilitikas O, Hoffman-Andrews L, Judy RL, Khan A, Kullo IJ, Puckelwartz MJ, Reza N, Satterfield BA, Singhal P; Penn Medicine Biobank; Arany Z, Cappola TP, Carruth ED, Day SM, Do R, Haggerty CM, Joseph J, McNally EM, Nadkarni G, Owens AT, Rader DJ, Ritchie MD, Sun YV, Voight BF, Levin MG, Damrauer SM.
Nat Genet. 2025 Apr;57(4):829-838. doi: 10.1038/s41588-025-02140-2.
The Causal Relationship Between Zinc and Osteoarthritis: A Two-Sample Mendelian Randomization Study
Gao T, Chen T, Ai C, Gu Y, Wang Y, Zhou X, Zhao C.
Biol Trace Elem Res. 2025 Apr 7. doi: 10.1007/s12011-025-04611-3.
Mendelian randomization analysis of blood metabolites and immune cell mediators in relation to GVHD and relapse
Yu X, Chen Y, Lei L, Li P, Lin D, Shen Y, Hou C, Chen J, Fan Y, Jin Y, Lu H, Wu D, Xu Y.
BMC Med. 2025 Apr 7;23(1):201. doi: 10.1186/s12916-025-04026-w.
Causal Links Between Gut Microbiota and Vitamin Deficiencies: Evidence from Mendelian Randomization Analysis
Hou ZX, Li WJ, Pi R, Wang HW, Dai MN, Ouyang Y, Li SY.
Curr Med Sci. 2025 Apr 7. doi: 10.1007/s11596-025-00038-y.
Single-cell transcriptome integrated with genome-wide association study reveals heterogeneity of carotid and femoral plaques and its association with plaque stability
Hou X, Li Z, Lin J, Lin W, Li L, Zheng X, Lai X, Zhu L, Guo P, Cai F, Zhang J, Li W, Yang C, Dai Y.
Sci Rep. 2025 Apr 7;15(1):11812. doi: 10.1038/s41598-025-96434-4.
Integrating microbial GWAS and single-cell transcriptomics reveals associations between host cell populations and the gut microbiome
Li J, Ma Y, Cao Y, Zheng G, Ren Q, Chen C, Zhu Q, Zhou Y, Lu Y, Zhang Y, Deng C, Chen WH, Su J.
Nat Microbiol. 2025 May;10(5):1210-1226. doi: 10.1038/s41564-025-01978-w.
Genetic correlations and causal associations between BMI, HDL-C, and postoperative infections: a two-sample Mendelian randomization study
Yang T, Chen Z, Cao D, Song W, Jiang J, Ma X, Mao Z, Guan X, Wu J, Shi R, Si X.
Sci Rep. 2025 Apr 7;15(1):11834. doi: 10.1038/s41598-025-95812-2.
Causal relationship between rosacea and psychiatric disorders: a bidirectional two-sample Mendelian randomization study
Li Y, Hu T, Jiang L, Ge L.
Arch Dermatol Res. 2025 Apr 7;317(1):683. doi: 10.1007/s00403-025-04142-w.
Revealing the mediating mechanisms between BMI and osteoarthritis: a Mendelian randomization and mediation analysis
Yu H, Wang J, Xu X, Li H, Guo J.
Aging Clin Exp Res. 2025 Apr 7;37(1):119. doi: 10.1007/s40520-025-03035-2.
Causal role of immune cells in thyroid cancer: a two-sample Mendelian randomization study
Wang S, Fang Z, Xiao W, Xie Y, Zhang Y, Liu Z.
Discov Oncol. 2025 Apr 7;16(1):481. doi: 10.1007/s12672-025-02249-0.
Warfarin use and vestibular dysfunction insights from NHANES data, network pharmacology, Mendelian randomization, and molecular docking
Liu S, Zhang L, Luo W.
Sci Rep. 2025 Apr 6;15(1):11748. doi: 10.1038/s41598-025-96681-5.
No Associations Between Genetically Predicted Chronotype, Insomnia, Daytime Sleepiness, or Physical Activity and Acne Vulgaris: A Two-Sample Mendelian Randomization Study
Tian C.
Clin Cosmet Investig Dermatol. 2025 Apr 6;18:827-835. doi: 10.2147/CCID.S510739.
Uncovering leading compounds for alzheimer’s disease treatment: mendelian randomization and virtual screening insights into plasma protein modulation
Sun X, Hu X, Wei J, An H.
Biol Res. 2025 Apr 5;58(1):19. doi: 10.1186/s40659-025-00598-2.
Assessing the genetic estimates of the association between plasma caffeine and cancer risk through Mendelian randomization
Wang H, Ma K, Shan M, Zhang G.
Eur J Nutr. 2025 Apr 5;64(4):145. doi: 10.1007/s00394-025-03663-4.
Causal relationship between mitochondrial proteins and risks of aortic aneurysms and aortic dissection: a Mendelian randomization study
Wang L, Lin Y, Lin Z, Wu Q, Zhong G, Chen L.
J Cardiothorac Surg. 2025 Apr 5;20(1):181. doi: 10.1186/s13019-025-03389-8.
Mendelian-based urolithiasis risk concerning fish consumption and fish oil supplement
Zhu J, Nie J.
Medicine (Baltimore). 2025 Apr 4;104(14):e41760. doi: 10.1097/MD.0000000000041760.
Causal associations between premature ovarian insufficiency and cardiovascular diseases: a Mendelian randomization study
Yang X, Lin T, Luo L, Chen H, Dai Y, Li D, Zhu L.
Gynecol Endocrinol. 2025 Dec;41(1):2487498. doi: 10.1080/09513590.2025.2487498.
Identification of biomarkers for endometriosis based on summary-data-based Mendelian randomization and machine learning
Xie Z, Feng Y, He Y, Lin Y, Wang X.
Medicine (Baltimore). 2025 Apr 4;104(14):e41804. doi: 10.1097/MD.0000000000041804.
Mendelian randomization analysis of the causal relationship between plasma proteins and childhood asthma
Wang C, Fan H, Sun Y, Sun L.
Medicine (Baltimore). 2025 Apr 4;104(14):e42050. doi: 10.1097/MD.0000000000042050.
Causal relationship between gut microbiota, metabolites, and short stature: a Mendelian randomization study
Zheng Z, Sun H, Zhang P, Cao F, Xiao X, Zhao T.
Pediatr Res. 2025 Apr 3. doi: 10.1038/s41390-025-03985-3.
Decoding the genetic links between substance use disorder and cancer vulnerability
Su X, Mo X, Kan J, Yang F, Zhang B, Huang Y.
Psychopharmacology (Berl). 2025 Apr 3. doi: 10.1007/s00213-025-06781-3.
A mendelian randomization study on the association between 731 types of immune cells and 91 types of blood cells with venous thromboembolism
Zhang Y, Wang R.
Thromb J. 2025 Apr 3;23(1):28. doi: 10.1186/s12959-025-00714-y.
Causal association of cathepsins with female infertility: a bidirectional Mendelian randomization analysis
Liu L, Liao M, Liu B, Huang Q, Wu H, Li M.
Obstet Gynecol Sci. 2025 Apr 3. doi: 10.5468/ogs.24254.
Health implications associated with fat-free mass: phenome-wide Mendelian randomization study
Ying Y, Zhang C, Wu S, Wang S, Lian J, Lin Y, Guan H, Cai D.
Cardiorenal Med. 2025 Apr 3:1-20. doi: 10.1159/000545641.
Causal relationship between graves' disease and mental disorders: A bidirectional Mendelian randomization study
Deng Y, Hao Z, Chen W, Zhang J, Zou Y, Zhang J, Xi Y, Xu J.
J Psychosom Res. 2025 Apr 3;192:112124. doi: 10.1016/j.jpsychores.2025.112124.
Plasma cytokine levels and PCOS risk: Mendelian randomization analysis reveals IL6R as a preventive factor
Li X, Li Y, Zhang B, Wang J, Yang Y, Du Y.
J Ovarian Res. 2025 Apr 3;18(1):69. doi: 10.1186/s13048-025-01647-w.
Dissecting causal relationships between gut microbiota, inflammatory factors, and acute kidney injury: A Mendelian randomization study
Huai J, Ye X.
Clin Nephrol. 2025 Apr 3. doi: 10.5414/CN111632.
Identifying blood mitochondrial DNA copy number as a biomarker for development of neurodegenerative diseases: Evidence from Mendelian randomization analysis
Lei S, Liu Y.
Neuroscience. 2025 Apr 2;573:421-429. doi: 10.1016/j.neuroscience.2025.04.003.
Mendelian Randomization Unveils a Causal Relationship Between Inflammation, Metabolism, and Systemic Sclerosis
Zeng Y, Zeng W, Li Z, Yang X, Pan J, Lei L.
medRxiv 2025.04.02.25325153; doi: https://doi.org/10.1101/2025.04.02.25325153
Metabolic Factors Mediate the Causal Effect of Physical Activity and Sedentary Behavior on Stroke and Its Subtypes: Evidence from Mendelian Randomization Study
Wei J, Zhao J, Yang K, Ma S, Zhang M, Sun Y, He C, Pan X, Zhu X.
Mol Neurobiol. 2025 Apr 2. doi: 10.1007/s12035-025-04881-x.
Association between sleep apnoea and arrhythmia: A multivariable Mendelian randomization study
He W, Wang J, Nie J, Wang DW, Ni L, Li D.
medRxiv 2025.04.02.25325145; doi: https://doi.org/10.1101/2025.04.02.25325145
Dissecting shared genetic architecture between hypothyroidism and immune-related diseases
Li S, Gong M.
medRxiv 2024.04.02.24305135; doi: https://doi.org/10.1101/2024.04.02.24305135
Thyroid function and hepatic fibrosis/cirrhosis: a two-sample Mendelian randomization study
Wang Y, Zhang X, Li Q, Zhang Q, Liu J.
Front Genet. 2025 Apr 2;16:1399353. doi: 10.3389/fgene.2025.1399353.
Exploring the Relationship Between Antipsychotic Drug Target Genes and Epilepsy: Evidence From Food and Drug Administration Adverse Event Reporting System Database and Mendelian Randomization
Yin Z, Zhan Z, Qiu Y, Wang M, Li J, Song B, Chen Z, Wu J, Wang Z.
Brain Behav. 2025 Apr;15(4):e70467. doi: 10.1002/brb3.70467.
Researching the causal relationship between immune cells and frontotemporal Dementia: A Mendelian Randomization analysis
Cheng Y, He X, Huang X, Mao F, Qin F, Wang Y.
Brain Res. 2025 Apr 2;1857:149608. doi: 10.1016/j.brainres.2025.149608.
Cross-ancestry genome-wide association study identifies new susceptibility genes for preeclampsia
Shan Y, Hu H, Chu Y.
BMC Pregnancy Childbirth. 2025 Apr 1;25(1):379. doi: 10.1186/s12884-025-07534-y.
Exploring glucagon-like peptide-1 receptor agonists as potential disease-modifying agents in autoimmune diseases
Yang Y, Liu W, Zhang Z, Zhang Y, Wang X, Wang J, Cai H, Liu Y, Meng R, Fu Y, Luo H, Yang L, Liu W.
J Autoimmun. 2025 Apr 1;153:103414. doi: 10.1016/j.jaut.2025.103414.
BMI matters: understanding the link between weight and severe psoriasis
Wang H, Hou S, Kang X, Yu C, Yang B, Shi Y, Li F, Li W, Gu J, Lei M, Lin Y, Wang G, Jin H, Liu X.
Sci Rep. 2025 Apr 1;15(1):11158. doi: 10.1038/s41598-025-94505-0.
Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis
Oliva M, Sarkar MK, March ME, Saeidian AH, Mentch FD, Hsieh CL, Tang F, Uppala R, Patrick MT, Li Q, Bogle R, Kahlenberg JM, Watson D, Glessner JT, Youssefian L, Vahidnezhad H, Tsoi LC, Hakonarson H, Gudjonsson JE, Smith KM, Riley-Gillis B.
Nat Commun. 2025 Apr 1;16(1):3101. doi: 10.1038/s41467-025-58310-7.
Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake
Sun L, Leng R, Liu M, Su M, He Q, Zhang Z, Liu Z, Wang Z, Jiang H, Wang L, Guo S, Xu Y, Huo Y, Miller CL, Banach M, Huang Y, Evans PC, Pelisek J, Camici GG, Berk BC, Offermanns S, Ge J, Xu S, Weng J.
J Clin Invest. 2025 Apr 1;135(7):e181928. doi: 10.1172/JCI181928.