Below you will find all the published and preprint scientific papers using FinnGen data.

2025

February

Autoimmune disease and risk of lymphoma: analysis from real-world data and Mendelian randomization study
Zhan L, Chen S, Liu Y, Lu T, Yu Z, Wang X, Zhou X.
BMC Cancer. 2025 Feb 25;25(1):351. doi: 10.1186/s12885-025-13754-4.
Causal Relationship between Branched-Chain Amino Acids and Inflammatory Bowel Disease: A Bidirectional and Multivariable Mendelian Randomization Study
Zhou J, Zhu F, Sun L.
Br J Hosp Med (Lond). 2025 Feb 25;86(2):1-17. doi: 10.12968/hmed.2024.0722.
Causal relationship between osteoporosis, bone mineral density, and osteonecrosis: a bidirectional two-sample Mendelian randomization study
Zhang C, Yu H, Miao Y, Wei B.
J Transl Med. 2025 Feb 25;23(1):226. doi: 10.1186/s12967-024-06030-9.
Increased risk of chronic diseases and multimorbidity in middle-aged and elderly individuals with early vision, hearing, or dual sensory impairments: insights from prospective cohort studies and Mendelian randomization analysis
Wang Y, Cheng F, Hou N, Tan Y, Zhang S, Hou Y, Guo W, Peng J, Li W, Wu J.
BMC Med. 2025 Feb 25;23(1):118. doi: 10.1186/s12916-025-03857-x.
Plasma proteins and herpes simplex virus infection: a proteome-wide Mendelian randomization study
Fu C, Xu W, Xu X, Zhao F, Zheng C, Yin Z.
Virus Genes. 2025 Feb 24. doi: 10.1007/s11262-025-02145-3.
Spleen volume in relation to ulcerative colitis and Crohn's disease: a Mendelian randomization study
Su Q, Li J, Lu Y, Liang J, Huang S, Wu M, He Y, An Z, Ding J, Zhang Z.
Sci Rep. 2025 Feb 24;15(1):6588. doi: 10.1038/s41598-025-90104-1.
Two-sample Mendelian randomization analysis of the causal relationship between lipid metabolism/fatty acid metabolism and pre-eclampsia
Yang D, Chen J, Wang X, Zhuang L, Feng H, Liao X, Mo T.
Ginekol Pol. 2025 Mar 12. doi: 10.5603/gpl.101256.
Cross-ancestry genome-wide association study and systems-level integrative analyses implicate new risk genes and therapeutic targets for depression
Li Y, Dang X, Chen R, Teng Z, Wang J, Li S, Yue Y, Mitchell BL, Zeng Y, Yao YG, Li M, Liu Z, Yuan Y, Li T, Zhang Z, Luo XJ.
Nat Hum Behav. 2025 Feb 24. doi: 10.1038/s41562-024-02073-6.
Proteome-wide Mendelian randomization identifies causal plasma proteins in prostate cancer development
Wu J, Yang Z, Ding J, Hao S, Chen H, Jin K, Zhang C, Zheng X.
Hum Genomics. 2025 Feb 24;19(1):17. doi: 10.1186/s40246-025-00724-x.
EPIraction - an atlas of candidate enhancer-gene interactions in human tissues and cell lines
Nurtdinov RN, Guigó R.
bioRxiv [Preprint]. 2025 Feb 23:2025.02.18.638885. doi: 10.1101/2025.02.18.638885.
Identifying genetic overlaps in obesity and metabolic disorders unlocking unique and shared mechanistic insights
Fu L, Han X, Wang Y, Hu YQ.
Free Radic Biol Med. 2025 Feb 23;231:80-93. doi: 10.1016/j.freeradbiomed.2025.02.033.
A large-scale genome-wide association study on female genital tract polyps highlights role of DNA repair, cell proliferation, and cell growth
Pathare ADS, Džigurski J, Pujol-Gualdo N, Rukins V, Peters M; Estonian Biobank Research Team; Mägi R, Salumets A, Saare M, Laisk T.
Hum Reprod. 2025 Feb 22:deaf025. doi: 10.1093/humrep/deaf025.
A large-scale genome-wide association study on female genital tract polyps highlights role of DNA repair, cell proliferation, and cell growth
Pathare ADS, Džigurski J, Pujol-Gualdo N, Rukins V, Peters M; Estonian Biobank Research Team; Mägi R, Salumets A, Saare M, Laisk T.
Hum Reprod. 2025 Apr 1;40(4):750-763. doi: 10.1093/humrep/deaf025.
Based on the resting-state functional magnetic resonance imaging reveals the causal relationship between the brain function network and the risk of tinnitus: a bidirectional Mendelian randomization analysis
Liu Y, Li C, Yao L, Tan Y, Shi L, Chen P.
Brain Imaging Behav. 2025 Feb 22. doi: 10.1007/s11682-025-00986-y.
Genetically predicted circulating immune cells and cytokines reveal the causal role of immune factors on female infertility: a two-sample mendelian randomization study
Dong KX, Mo JH, Yan J, Cheng Y, Chen HX, Xu NX, Dou ZY, Zhu H, Zhu L, Huang HF.
BMC Pregnancy Childbirth. 2025 Feb 22;25(1):195. doi: 10.1186/s12884-025-07318-4.
The 2-Step Mendelian Randomisation Study Assesses Genetic Causality and Potential Mediators of Periodontal Disease and Atrial Fibrillation
Zhang X, Lian C, Shi S, Li J, Wang L, Guo Z, Liu N, Wang H, Hu Y, Du B.
Int Dent J. 2025 Feb 22:S0020-6539(25)00003-6. doi: 10.1016/j.identj.2024.12.029.
Genetic evidence identifies a causal relationship between EBV infection and multiple myeloma risk
Li J, Tan R, Yang B, Du C, Tian J, Yang Z, Tang D.
Sci Rep. 2025 Feb 21;15(1):6357. doi: 10.1038/s41598-025-90479-1.
Gut microbiota and male fertility: A two-sample Mendelian randomization study
Wang ZH, Kang YF.
Medicine (Baltimore). 2025 Feb 21;104(8):e41542. doi: 10.1097/MD.0000000000041542.
Mendelian randomization analysis revealed a gut microbiota-eye axis in acute anterior uveitis
Mi Y, Chen L, Liao N, Wan M.
Eye (Lond). 2025 Feb 21. doi: 10.1038/s41433-025-03715-3.
Moderate and severe depression increase the incidence of cholelithiasis: Results from Mendelian randomization study and the NHANES 2017-March 2020
Ma M, Xie K, Jin T, Xu F.
Soc Psychiatry Psychiatr Epidemiol. 2025 Feb 21. doi: 10.1007/s00127-025-02843-1.
Circulating inflammatory cytokines and risk of aortic stenosis: A Mendelian randomization analysis
Qiu X, Wu J, Chen Z, Zhang Y, Cao L, Wang N, Teng J, Su C, Cheng C, Wang F, Chen W.
Cytokine. 2025 Feb 21;189:156887. doi: 10.1016/j.cyto.2025.156887.
The causal relationship between hallux valgus and endogenous pathogenic factors: A 2-sample Mendelian randomization
Xie YL, Liang JY, Du GF, Lu HJ, Luo WJ, Wu JH, Sheng ZH.
Medicine (Baltimore). 2025 Feb 21;104(8):e41647. doi: 10.1097/MD.0000000000041647.
Triangular Causality Among Pulmonary Hypertension, Sleep Disorders, and Brain Structure at the Genetic Level: A Mendelian Randomization Study Focused on the Lung-Brain Axis
Zhang C, Su X, Zhang Y, He P, Kong X, Zhang Z, Wei Y, Shi Y.
Nat Sci Sleep. 2025 Feb 21;17:343-356. doi: 10.2147/NSS.S495071.
Identification of potential diagnostic biomarkers and drug targets for endometriosis from a genetic perspective: a mendelian randomization study
Zhu Y, Cheng F, Zhu L, Yang X, He M, Wang W.
Gynecol Obstet Invest. 2025 Feb 20:1-22. doi: 10.1159/000543707.
Mendelian randomization analyses uncover causal relationships between brain structural connectome and risk of psychiatric disorders
Xiao K, Chang X, Ye C, Zhang Z, Ma T, Su J.
medRxiv 2025.02.20.25322606; doi: https://doi.org/10.1101/2025.02.20.25322606
Leukemia and risk of stroke: a Mendelian randomization analysis
Yi X, Zhu J, Zhang X, Huang N, Cheng Y.
BMC Neurol. 2025 Feb 19;25(1):68. doi: 10.1186/s12883-025-04079-7.
A multistage, multitask transformer-based framework for multi-disease diagnosis and prediction using personal proteomes
Li H, Li Y, Liu Y, Cooper-Knock J, Gao P, Shen X, Chen S, Xing X, Zhang S.
medRxiv 2025.02.19.25322536; doi: https://doi.org/10.1101/2025.02.19.25322536
Major depressive disorder and the development of cerebral small vessel disease: A Mendelian randomization study
Lu T, Luo L, Yang J, Li Y, Chen D, Sun H, Liao H, Zhao W, Ren Z, Xu Y, Yu S, Cheng X, Sun J.
J Affect Disord. 2025 May 15;377:68-76. doi: 10.1016/j.jad.2025.02.067.
Dissecting the genetic etiology of intestinal obstruction: mendelian randomization identifies potential therapeutic targets
Haodong Z, Baoping C, Jiongjiong C, Jia C, Hui L, Yu W, Bocheng D.
medRxiv 2025.02.19.25322532; doi: https://doi.org/10.1101/2025.02.19.25322532
Prebiotic xylo-oligosaccharides for alleviation of hepatic steatosis: Results from a four-month dietary intervention and determinants of response
Hintikka JE, Permi P, Lehtonen M, Lensu S, Driuchina A, Jormanainen M, Laukkanen J, Bayal N, Erawijantari PP, O’Connell TM, Lahti L, Pekkala S.
bioRxiv 2025.02.19.638992; doi: https://doi.org/10.1101/2025.02.19.638992
Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases
Mitchell J, Camacho N, Shea P, Stopsack KH, Joseph V, Burren OS, Dhindsa RS, Nag A, Berchuck JE, O'Neill A, Abbasi A, Zoghbi AW, Alegre-Díaz J, Kuri-Morales P, Berumen J, Tapia-Conyer R, Emberson J, Torres JM, Collins R, Wang Q, Goldstein D, Matakidou A, Haefliger C, Anderson-Dring L, March R, Jobanputra V, Dougherty B, Carss K, Petrovski S, Kantoff PW, Offit K, Mucci LA, Pomerantz M, Fabre MA.
Nat Commun. 2025 Feb 19;16(1):1779. doi: 10.1038/s41467-025-56944-1.
Human blood metabolites and obesity-related asthma-a Mendelian randomization study
Li X, Xiao Y, Chen Y, Zeng G, Chen L.
J Asthma. 2025 Feb 18:1-9. doi: 10.1080/02770903.2025.2469313.
Exploring the Diet-diverticular Disease Link: Insights from a Comprehensive Mendelian Randomization Study
Zhou J, Xu Y, Wang H, Wang K, Chen C.
Curr Med Chem. 2025 Feb 18. doi: 10.2174/0109298673342480250203111209.
Unveiling the Connection Between Micronutrients and Autoimmune Thyroiditis: Are They True Friends?
Yu Y, Tong K, Deng J, Wu J, Yu R, Xiang Q.
Biol Trace Elem Res. 2025 Feb 18. doi: 10.1007/s12011-025-04548-7.
Exploring the causal influence of 731 immune cells on 4 different glaucoma subtypes using a two-sample mendelian randomization method
Han X, Wang J, Su X, Guo X, Ye H.
Sci Rep. 2025 Feb 18;15(1):5987. doi: 10.1038/s41598-025-90545-8.
Associations Between Gut Microbiota and Diabetic Nephropathy: A Mendelian Randomization Study
Xiong Y, Zhu X, Xu H, Zheng Z, Luo Q.
Aging Med (Milton). 2025 Feb 18;8(1):e70009. doi: 10.1002/agm2.70009.
Analysis of the Genetic Association Between Immune Cell Phenotypes and Chronic Rhinosinusitis
Enze Wang, Yingxuan Sun, He Zhao, Meng Wang, Zhiwei Cao
Researchsquare, 17 February 2025, doi: 10.21203/rs.3.rs-6026517/v1
The causal association of Cardiometabolic diseases and Sepsis-related outcomes: A Mendelian randomization and population study
Qi M, Wei J, Zhang M, Jiao C, He C, Sui L, Ma S, Mao Z, Pan X, Zhu X.
Shock. 2025 Feb 17. doi: 10.1097/SHK.0000000000002538.
Investigating the causal relationship between the plasma lipidome and cholangiocarcinoma mediated by immune cells: a mediation Mendelian randomization study
Yin H, Yang K, Lou Y, Zhao Y.
Sci Rep. 2025 Feb 17;15(1):5807. doi: 10.1038/s41598-025-90140-x.
Causal associations between gut microbiota and cancers
Yue Z, yan J, Shen L, Zhao C, Yang X, Yao Y, Song D, Xu C, Bi C, Xiong Z, Ma H, Liu Z.
medRxiv 2025.02.17.25322359; doi: https://doi.org/10.1101/2025.02.17.25322359
Impulsivity facets and substance use involvement: insights from genomic structural equation modeling
Vilar-Ribó L, Hatoum AS, Grotzinger AD, Mallard TT; 23andMe Research Team; Elson S, Fontanillas P, Palmer AA, Gustavson DE, Sanchez-Roige S.
Psychol Med. 2025 Feb 17;55:e51. doi: 10.1017/S0033291725000145.
Narcolepsy as a potential risk factor for Schizophrenia
Eghtedarian R, Tervi AM, Jones SE; FinnGen; Partinen M, Viippola E, Ollila HM.
Transl Psychiatry. 2025 Feb 17;15(1):55. doi: 10.1038/s41398-025-03259-w.
Role of PD-L1 in mediating the effect of lipid on ulcerative colitis: a mediation Mendelian randomization study
Li P, Wang Y, Hu H, Sun B.
Front Genet. 2025 Feb 17;16:1390605. doi: 10.3389/fgene.2025.1390605.
Untangling immune cell contributions in the progression from GERD to Barrett's esophagus and esophageal cancer: Insights from genetic causal analysis
Zhang T, Tang X.
Int Immunopharmacol. 2025 Feb 17;150:114271. doi: 10.1016/j.intimp.2025.114271.
Unraveling the causal association between inflammatory bowel diseases and uveitis through mendelian randomization analysis
Zhong M, An H, Gan H.
Sci Rep. 2025 Feb 16;15(1):5686. doi: 10.1038/s41598-025-90462-w.
Causal relationship of polyunsaturated fatty acids with mental disorders: a systematic review and meta-analysis
Yao Y, Yang X, Yan J, Lv H, Yue Z, Yu J, Ye M, Lin X, Qian C, Zhang H, Liu Z.
medRxiv 2025.02.16.25322383; doi: https://doi.org/10.1101/2025.02.16.25322383
Association of cancers with the occurrence and 28-day mortality of sepsis: a mendelian randomization and mediator analysis
Cheng D, Pan S, Fang X, Wang S, Zou X, Shu H, Yang X, Xu J, Shang Y.
Sci Rep. 2025 Feb 15;15(1):5600. doi: 10.1038/s41598-025-89354-w.
CDC42: unlocking a novel therapeutic target for primary sclerosing cholangitis through Mendelian randomization
Zhou J, Xu Y, Wang H, Chen C, Wang K.
Am J Transl Res. 2025 Feb 15;17(2):1076-1086. doi: 10.62347/BTYN8678.
Investigating the causal relationship between the gut microbiome and rheumatoid arthritis: mediating effects of immune cells
Lan W, Lu Q, Ma W, Jiang Z, Chen Y, Wang Z, Yao X, Tang F.
J Transl Med. 2025 Feb 15;23(1):187. doi: 10.1186/s12967-025-06206-x.
Genetically proxied phosphodiesterase type 5 (PDE5) inhibition and risk of dementia: a drug target Mendelian randomisation study
Brennan SO, Tinworth AC.
Mol Neurobiol . 2025 Jun;62(6):7864-7874. doi: 10.1007/s12035-025-04732-9.