Below you will find all the published and preprint scientific papers using FinnGen data.

2025

March

Unraveling the role of gut microbiota and plasma metabolites in fibromyalgia: Insights from Mendelian randomization and dietary interventions
Niu M, Li J, Zhuang X, Yangyang C, Chen Y, Zhang Y, Maes M.
Mol Pain. 2025 Jan-Dec;21:17448069251332140. doi: 10.1177/17448069251332140.
Causal effect of life-course adiposity on the risk of respiratory diseases: a Mendelian randomization study
Chen XX, Lu FY, Wang Y, Zhang L, Li SQ, Lin YN, Yan YR, Ding YJ, Li N, Zhou JP, Sun XW, Li QY.
Nutr Metab (Lond). 2025 Mar 21;22(1):25. doi: 10.1186/s12986-025-00915-2.
Associations of 2923 plasma proteins with incident inflammatory bowel disease in a prospective cohort study and genetic analysis
Zhang X, Zhao H, Wan M, Man J, Zhang T, Yang X, Lu M.
Nat Commun. 2025 Mar 21;16(1):2813. doi: 10.1038/s41467-025-57879-3.
Causal association between genetically predicted primary aldosteronism and aortic aneurysm and aortic dissection: A Mendelian randomization study
Liu S, Wan J, Yang Y, Wang D, Hou J, Wang P.
Medicine (Baltimore). 2025 Mar 21;104(12):e41951. doi: 10.1097/MD.0000000000041951.
Causal relationships between schizophrenia and psoriasis: a two-sample Mendelian randomization study
Miao L, Miao T, Zhang Y, Hao J.
BMC Psychiatry. 2025 Mar 20;25(1):264. doi: 10.1186/s12888-025-06687-6.
Identification of Novel Therapeutic Targets for Hypertension
Zheng Z, Chen R, Liu M, Ding Y, Xu S, Hou C, Li S.
Hypertension. 2025 Mar 20. doi: 10.1161/HYPERTENSIONAHA.124.24277.
Causality of Childhood and Adult Body Mass Index on Sick Sinus Syndrome: A Mendelian Randomization Study
Xu G, Liu Z, Hou P.
Cureus. 2025 Mar 20;17(3):e80913. doi: 10.7759/cureus.80913.
Cross-tissue transcriptome-wide association study reveals novel psoriasis susceptibility genes
Yan F, Tao J, Liu J, Chen Y, Huang Z.
J Transl Autoimmun. 2025 Mar 20;10:100286. doi: 10.1016/j.jtauto.2025.100286.
Uterine Fibroids Increase Stroke Risk: a Mendelian Randomization Study
Zheng M.
medRxiv 2025.03.20.25324360; doi: https://doi.org/10.1101/2025.03.20.25324360
Using polygenic and transcriptional risk scores to investigate psychiatric and cognitive symptoms in Parkinson's disease
Gilchrist L, Pain O, Marriott H, Pfaff A, Watson CJ, Iacoangeli A, Koks S, Lewis CM, Proitsi P.
medRxiv 2025.03.20.25324166; doi: https://doi.org/10.1101/2025.03.20.25324166
Multi-omic biomarkers associated with multiple sclerosis: from Mendelian randomization to drug prediction
Yang W, Liu C, Li Z, Cui M.
Sci Rep. 2025 Mar 19;15(1):9421. doi: 10.1038/s41598-025-94303-8.
Iron as a Modifiable Factor for Adverse Pregnancy Outcomes: Refining and Understanding Causal Estimates Using Mendelian Randomization
Wu Y, He L, Liu C, Xia F, Li Z, Chen L, Wang T.
Biol Trace Elem Res. 2025 Mar 19. doi: 10.1007/s12011-025-04576-3.
Multi-Omics Integration Reveals Mitochondrial Gene Regulation as a Determinant of Tuberculosis Susceptibility: A Mendelian Randomization Approach
Fang T, Chen Y, Yuan F, Ma Y, Wang Q, Yao Y, Cai S, Jin W, Miao Q, Hu B.
Biomedicines. 2025 Mar 19;13(3):749. doi: 10.3390/biomedicines13030749.
Vitamin D levels, assessment of evidence for an association between vitamin D deficiency and atherosclerosis: a two-way Mendelian randomization study
Liu C, Huang X, Huang Y, Jin H.
medRxiv 2025.03.19.25324287; doi: https://doi.org/10.1101/2025.03.19.25324287
Multi-level Regulatory Roles of Lactate Metabolism Gene Network in Oral Cancer: Machine Learning Insights
Liu Z, Shen X.
medRxiv 2025.03.19.25324051; doi: https://doi.org/10.1101/2025.03.19.25324051
Gout drives metabolic dysfunction-associated steatotic liver disease through gut microbiota and inflammatory mediators
Liu S, Li F, Cai Y, Sun L, Ren L, Yin M, Cui H, Pan Y, Gang X, Wang G.
Sci Rep. 2025 Mar 19;15(1):9395. doi: 10.1038/s41598-025-94118-7.
A Mendelian randomization study to reveal gut-disc axis: causal associations between gut microbiota with intervertebral disc diseases
Ge Y, Yang H, Fu Y, Zhou J, Cheng Z, Fan X, Yu Y.
Eur Spine J. 2025 Mar 19. doi: 10.1007/s00586-025-08795-z.
Identifying Lipid Metabolism-Related Therapeutic Targets and Diagnostic Markers for Lung Adenocarcinoma by Mendelian Randomization and Machine Learning Analysis
Wei S, Guangyao Z, Xiangdong T, Feng G, Lianmin Z, Zhenfa Z.
Thorac Cancer. 2025 Mar;16(6):e70020. doi: 10.1111/1759-7714.70020.
Causal Associations Between the Presence of Prostate Cancer or Testosterone Levels and Bladder Cancer Risk: A Mendelian Randomization Study
Ren W, Zhu Y.
Clin Genitourin Cancer. 2025 Mar 19;23(3):102334. doi: 10.1016/j.clgc.2025.102334.
Assessing Causality Between Plasma Brain-Derived Neurotrophic Factor With Major Depression Disorder: A Bidirectional Mendelian Randomization Study
Chen M, Huang HZ, Liu YH, Li Q, Fu LY, Hou CL.
Brain Behav. 2025 Mar;15(3):e70425. doi: 10.1002/brb3.70425.
Mendelian Randomization Analysis Identifies Causal Effects of Multi-Site Chronic Pain on Obstructive Sleep Apnea
Wang Z, Chen L, Kang R, Li Z, Fan J, Peng Y, He Y, Zhao X.
Nat Sci Sleep. 2025 Mar 18;17:463-473. doi: 10.2147/NSS.S487056.
Obesity- and age-dependent genetic regulation of the plasma proteome in children and adolescents
Thielemann R, Stinson SE, Huang Y, Holm LA, Gräf JF, Rohde PD, Møller PL, Illeris Poggi AI, Vølund Anderson L, Fonvig CE, Thiele M, Krag A, Rasmussen S, Holm J-C, Hansen T.
medRxiv 2025.03.18.25324169; doi: https://doi.org/10.1101/2025.03.18.25324169
The Role of the Major Histocompatibility Complex Region on Chromosome 6 in Skin Atrophy: A Mendelian Randomization Study
Zhao C, Fan Z, Zhang R, Sun Y, Li WY.
J Cosmet Dermatol. 2025 Mar;24(3):e70040. doi: 10.1111/jocd.70040.
Exploring the causal effects of physical activity, diet, and nutrition on hypertension and hyperlipidemia: a multivariable Mendelian randomization analysis
Qian H, Liu Y, Choi H, Lee S.
BMC Cardiovasc Disord. 2025 Mar 18;25(1):196. doi: 10.1186/s12872-025-04539-5.
Impact of Glucagon-like Peptide-1 Receptor Agonists on Mental Illness: Evidence from a Mendelian Randomization Study
Xiang L, Peng Y.
Int J Mol Sci. 2025 Mar 18;26(6):2741. doi: 10.3390/ijms26062741.
Genome-wide association study of dry eye disease reveals shared heritability with systemic comorbidities
Gorman BR, Huang JJ, Barr PB, Halladay CW, Nealon CL, Chatzinakos C, Francis M, Jiang C, VA Million Veteran Program, Greenberg PB, Wu W-C, Pyarajan S, Choquet H, Bigdeli TB, Iyengar SK, Peachey NS, Galor A.
medRxiv 2025.03.18.25324218; doi: https://doi.org/10.1101/2025.03.18.25324218
Risk factors for non-responsiveness to 5-aminosalicylic acid in patients with ulcerative colitis identified using retrospective clinical study and Mendelian randomization
Ye ZN, Liu XT, Gu YM, Mao SX, Liang DH, Zhan K, Lei HQ, Huang SG.
Sci Rep. 2025 Mar 17;15(1):9182. doi: 10.1038/s41598-025-89620-x.
Shared genetic investigation of asthma and blood eosinophils in relation to chronic rhinosinusitis
Li X, Li J, Xue S, Gao Y, Wan L, Wang C, Zhang Y, Zhang L.
Allergy Asthma Clin Immunol. 2025 Mar 17;21(1):11. doi: 10.1186/s13223-025-00956-5.
Trans-ancestry genome-wide association meta-analysis of gallstone disease
Lim J, Vujkovic M, Levin MG, Lorenz K, Voight BF, Zhang DY, Dudek MF, Pahl MC, Pippin JA, Su C, Manduchi E, Wells AD, Grant SFA, Abramowitz S, Damrauer SM, Mukherjee S, Yang G, Kaplan DE, Rader DJ.
medRxiv 2025.03.16.25324077; doi: https://doi.org/10.1101/2025.03.16.25324077
Genetic insights into idiopathic pulmonary fibrosis: a multi-omics approach to identify potential therapeutic targets
Wen Z, Liang W, Yang Z, Liu J, Yang J, Xu R, Lin K, Pan J, Chen Z.
J Transl Med. 2025 Mar 16;23(1):337. doi: 10.1186/s12967-025-06368-8.
DNA Methylation-Regulated ZDHHC13 Promotes the Progression of Parkinson's Disease
Liao J, Bei L, Nie P, Liu P, Zhang Y.
Mol Neurobiol. 2025 Mar 15. doi: 10.1007/s12035-025-04829-1.
The Causal Relationship Between Gut and Skin Microbiota and Chronic Obstructive Pulmonary Disease:A Bidirectional Two-Sample Mendelian Randomization Analysis
Luo Z, Liao G, Meng M, Huang X, Liu X, Wen W, Yue T, Yu W, Wang C, Jiang Y.
Int J Chron Obstruct Pulmon Dis. 2025 Mar 15;20:709-722. doi: 10.2147/COPD.S494289.
Thyroid function and multiple sclerosis: a two-sample mendelian randomization study and mediation analysis
Ren Y, Wang X, Wang W, Wang Z.
Sci Rep. 2025 Mar 15;15(1):9022. doi: 10.1038/s41598-025-89888-z.
Circulating branched-chain amino acids and risk of psychiatric disorders: A two-sample Mendelian randomization study
Gao X, Zhang W, Wang F.
J Psychosom Res. 2025 Mar 15;192:112101. doi: 10.1016/j.jpsychores.2025.112101.
Association between 91 circulating inflammatory proteins and the risk of glaucoma: A Mendelian randomization study
Xu W, Fan Q, Meng Y, Nie Z, Sawut A, Xie S, Chen C.
Sci Rep. 2025 Mar 14;15(1):8876. doi: 10.1038/s41598-025-92153-y.
Self-reported myopia and age-related cataract: a two-sample Mendelian randomization study
Liu H, Wang F, Wei J.
Sci Rep. 2025 Mar 14;15(1):8839. doi: 10.1038/s41598-025-93564-7.
Association between dietary intakes and pregnancy complications: a two-sample Mendelian randomization analysis
Zhao Z, Chang T, Liu X, Zhang X, Liu X, Zhang Y, Chen J, Zhang Y, Lu M.
BMC Pregnancy Childbirth. 2025 Mar 14;25(1):286. doi: 10.1186/s12884-025-07385-7.
Novel Parkinson's Disease Genetic Risk Factors Within and Across European Populations
The Global Parkinson's Genetics Program (GP2), Leonard HL.
medRxiv 2025.03.14.24319455; doi: https://doi.org/10.1101/2025.03.14.24319455
Proteomic signatures of type 2 diabetes predict the incidence of coronary heart disease
Li Y, Li D, Lin J, Zhou L, Yang W, Yin X, Xu C, Cao Z, Wang Y.
Cardiovasc Diabetol. 2025 Mar 14;24(1):120. doi: 10.1186/s12933-025-02670-3.
Genomic and proteomic signatures highlight diverse pathways between obesity and type-2 diabetes
Åsa Johansson, Pascal Mutie, Torgny Karlsson
Researchsquare, 13 March 2025, doi: 10.21203/rs.3.rs-6079296/v1
Is metabolic syndrome a risk factor for skin cancer? A UKBiobank Observational and two Sample Mendelian randomization Study
Black EAM, Allemani C, Dudding T.
Cancer Epidemiol Biomarkers Prev. 2025 Mar 13. doi: 10.1158/1055-9965.EPI-24-1388.
Causal effect of the 25-Hydroxyvitamin D concentration on ocular diseases: A Mendelian randomization study
Luo X, Ruan Z, Liu L.
Sci Rep. 2025 Mar 13;15(1):8701. doi: 10.1038/s41598-025-93613-1.
Causal associations between 26 musculoskeletal disorders and gut microbiota: a Mendelian randomization analysis with Bayesian validation
Wang Y, Sun Y, Liao H.
World J Microbiol Biotechnol. 2025 Mar 13;41(3):106. doi: 10.1007/s11274-025-04318-6.
Ischemic Stroke May Increase the Risk of Crohn's Disease and Ulcerative Colitis: Evidence from a Bidirectional Mendelian Randomization Study
Luo X, Yao L, Chen Y, Song Y.
World Neurosurg. 2025 Apr;196:123718. doi: 10.1016/j.wneu.2025.123718.
Exploring Causal Relationships Between Gut Microbiota, Inflammatory Cytokines, and Inflammatory Dermatoses: A Mendelian Randomization Study
Huang Z, Lu T, Lin J, Ding Q, Li X, Lin L.
Clin Cosmet Investig Dermatol. 2025 Mar 13;18:579-592. doi: 10.2147/CCID.S496091.
Unraveling the Molecular Nexus Between Ankylosing Spondylitis and IgA Nephropathy: Insights from Mendelian Randomization and Bioinformatics Analysis
Shao N, Tan K, Chen P, Luo Q.
Nephron. 2025 Mar 12:1-22. doi: 10.1159/000544970.
Placental weight as a predictor of future health: Insights from a large-scale genome-wide association study
Zhang Q, Xu T, Yu S, Wu S, Yang Y, Wu H, Zhang J.
Placenta. 2025 Mar 12;164:10-20. doi: 10.1016/j.placenta.2025.03.006.
Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease
Ao L, van Heemst D, Jukema JW, Rensen PCN, Willems van Dijk K, Noordam R.
J Lipid Res. 2025 Apr;66(4):100778. doi: 10.1016/j.jlr.2025.100778.
Investigation of Potential Targets for Bupleuri Radix in the Treatment of Subacute Thyroiditis
Lei X, Lv L, Ma Y, Zhang C, Li L, Huang Y.
Int J Endocrinol. 2025 Mar 11;2025:7460422. doi: 10.1155/ije/7460422.
Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses
Pujol Gualdo N, Džigurski J, Rukins V, Pajuste FD, Wolford BN, Võsa M, Golob M, Haug L, Alver M, Läll K, Peters M, Brumpton BM; Estonian Biobank Research Team; Palta P, Mägi R, Laisk T.
Nat Med. 2025 Mar 11. doi: 10.1038/s41591-025-03543-8.