På den här sidan listar vi alla vetenskapliga publikationer som har använt data från FinnGen-studien.

2025

September

Bidirectional Mendelian randomization and immune cell mediation analysis: A STROBE-MR study unveiling the causal link between non-small cell and small cell lung cancers
Gao Y, Yao B, He S, Zhang G, Zhang X, Qi R, Ma X, Li X, Chen X, Zheng H, Hou W, Li C, Hua B, Guo Q.
Medicine (Baltimore) . 2025 Sep 12;104(37):e41820. doi: 10.1097/MD.0000000000041820.
The multi-omics insights into mitochondrial dysfunction in the pathogenesis of cholelithiasis
Hou H, Jiang Z, Zhu L.
Medicine (Baltimore) . 2025 Sep 12;104(37):e44525. doi: 10.1097/MD.0000000000044525.
Exploring the causal relationship between sedentary behavior and cardiovascular disease: A two-sample Mendelian randomization analysis
Cao Y, Hao Q, Xia N, Feng Y.
Medicine (Baltimore) . 2025 Sep 12;104(37):e44543. doi: 10.1097/MD.0000000000044543.
Expanded map of genomic imprinting reveals insight into human disease
Craig Smail, Warren A. Cheung, Boryana Koseva, Adam F. Johnson, Chengpeng Bi, Carl F. Schreck, Michael Lydic, Kristin Holoch, Elena Repnikova, John Herriges, Courtney Marsh, Isabelle Thiffault, Tomi Pastinen, Elin Grundberg
medRxiv 2025.09.15.25335770; doi: https://doi.org/10.1101/2025.09.15.25335770
Endocrine disruptors and male infertility: multi-omics identification of key genes in non-obstructive azoospermia
Yanggang Hong, Yirong Wang, Jiajun Li, Wanyi Shu, Haolin Chen, Congde Chen
J Assist Reprod Genet (2025). https://doi.org/10.1007/s10815-025-03664-6
Identifying potential therapeutic targets for prostate cancer with mediating role in tumor immunity
Zhechun Wu, Sihan Li, Yuqing Li, Zhizhi Wang, Wei Wang
Discov Onc 16, 1428 (2025). https://doi.org/10.1007/s12672-025-02985-3
Integrative genome-wide analysis unveils the genetic landscape of gallstone disease and highlights novel loci with therapeutic potential
Chen H, Liu Z, Du H, Zheng M, Wan Z, Zhao N, Li G, Bai X, Wu D, Mi J.
BMJ Open Gastroenterol . 2025 Sep 14;12(1):e001976. doi: 10.1136/bmjgast-2025-001976.
Integrative genome-wide analysis unveils the genetic landscape of gallstone disease and highlights novel loci with therapeutic potential
Chen H, Liu Z, Du H, Zheng M, Wan Z, Zhao N, Li G, Bai X, Wu D, Mi J.
BMJ Open Gastroenterol . 2025 Sep 14;12(1):e001976. doi: 10.1136/bmjgast-2025-001976.
Causal Links Between Cerebrospinal Fluid Metabolites and Postpartum Depression: A Bidirectional Mendelian Randomization Study
Long Y, Liu H, Ban R, Xu Z, Xu T.
Int J Womens Health . 2025 Sep 5:17:2919-2928. doi: 10.2147/IJWH.S540467. eCollection 2025.
The genetic relationships between post-traumatic stress disorder and its corresponding neural circuit structures
Gong Q, Lyu H, Kang L, Ma S, Zhang N, Xie X-H, Zhou E, Deng Z, Liu J, Liu Z.
J Affect Disord. 2025 Sep 12;393(Pt A):120323. doi: 10.1016/j.jad.2025.120323
Genetically proxied tumour necrosis factor inhibition and pregnancy-related maternal and foetal outcomes in the general population: a Mendelian randomization study
Zhao SS, Woolf B, Rogne T, Gill D.
Rheumatol Adv Pract . 2025 Aug 29;9(3):rkaf100. doi: 10.1093/rap/rkaf100. eCollection 2025.
Dissecting Causal Relationships Between Gut Microbiota, Plasma Metabolites and Bladder Cancer: A Two-Step Mendelian Randomization Study
Che K, Qian D, Cui S, Xie F.
Health Sci Rep . 2025 Sep 9;8(9):e71206. doi: 10.1002/hsr2.71206. eCollection 2025 Sep.
Bidirectional Mendelian randomization analysis of the causal relationship between fibromyalgia and insomnia
Jin Gao, Liangke Pan, Zhenglun Pan
Researchsquare, 12 September 2025, doi:10.21203/rs.3.rs-7169915/v1
Deciphering diabetic neuropathy: immune cell causality revealed
Yu Y, Yang X, Yin Y, Deng J, Chen C, Yu R.
Neurol Res . 2025 Sep;47(9):782-790. doi: 10.1080/01616412.2025.2503456.
Perturbations in lipid metabolism mediate the relationship between cholecystectomy and dementia: A mediation Mendelian randomization study
Gu H, Yu K, Zhou J, Chu B, Zhang W, Dong J, He J.
J Alzheimers Dis . 2025 Sep 11:13872877251376316. doi: 10.1177/13872877251376316.
Genes and environment profoundly affect the human virome
Kamitaki N, Tang D, McCarroll S, Loh, P-R.
bioRxiv 2025.09.08.674901; doi: https://doi.org/10.1101/2025.09.08.674901
Deciphering the Genetic Association Between the FODMAP Diet and Recurring Oral Aphthae-The Mediating Role of Ferroptosis
Jia B, Wu X, Wang Q, Ren J, Li G, Zheng X, Yang S.
Food Sci Nutr . 2025 Sep 9;13(9):e70949. doi: 10.1002/fsn3.70949. eCollection 2025 Sep.
Association between copper exposure and renal fibrosis in patients with chronic kidney disease: evidence from Mendelian randomization and a retrospective study
Liu K, Yu M, He Y, Wang T, Hu H, Wan Z, Shuai P, Chen S, Li G, Wang L, Zhong X.
Front Public Health . 2025 Aug 25:13:1657180. doi: 10.3389/fpubh.2025.1657180. eCollection 2025.
The Role of Plasma Metabolites in Mediating the Effect of Gut Microbiota on Obstructive Sleep Apnea: A Two-Step, Two-Sample Mendelian Randomization Study
Wang X, Zhao R, Guo J, Yang K, Xu B.
Nat Sci Sleep . 2025 Sep 3:17:2119-2130. doi: 10.2147/NSS.S527778. eCollection 2025.
Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: a multi-ancestry drug-target Mendelian randomization study
Joshua Reitz, Daniel B. Rosoff, Tyler Perlstein, Alexandra Wagner, Jeesun Jung, Josephin Wagner, Benjamin C. Reiner, Falk W. Lohoff
Mol Psychiatry 30, 6119–6133 (2025). https://doi.org/10.1038/s41380-025-03199-3
Genetic Association of Lipids and Lipid-Lowering Drug Target Genes With Atopic Dermatitis: A Drug Target Mendelian Randomization Study
Luo M, Lin J, Zhuo Q, Lin L, Han Y.
Health Sci Rep . 2025 Sep 7;8(9):e71040. doi: 10.1002/hsr2.71040. eCollection 2025 Sep.
Vitamin A and vitamin B12 levels and coronary artery atherosclerosis: Univariate and multivariate Mendelian randomization analysis
Huang L, Shi J, Li H, Lin Q.
Medicine (Baltimore) . 2025 Sep 5;104(36):e44244. doi: 10.1097/MD.0000000000044244.
MRI-Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites
Ahmed A, Cule M, Naz A, Thanaj M, Sorokin EP, Odoemelam CS, Whitcher B, Sattar N, Bell JD, Thomas EL, Yaghootkar H.
J Obes . 2025 Aug 31:2025:7792701. doi: 10.1155/jobe/7792701. eCollection 2025.
Exploration of causal relationship between transplant rejection and immune cells: A two-sample Mendelian randomization study
Xue F, Wu X, Ni M, Jiang T, Wang H, Ma Y, Wu Q.
Transpl Immunol . 2025 Sep:92:102278. doi: 10.1016/j.trim.2025.102278.
The Relationship Between Human Cerebrospinal Fluid Proteins and the Risk of Delirium: A Study Based on Genetic Data
Xu Z, Ye F, Yuan Z, Liu C, Zhu S, Li B, Wu Q.
Brain Behav . 2025 Sep;15(9):e70836. doi: 10.1002/brb3.70836.
Potential Causal Relationships Between Circulating Micronutrient Levels and Multiple Neuroimmune Diseases: A Genetic Association Analysis
Chen L, Wu X, Wang K, Zhou X, Mou Y, Liu Z, Shen Z, Lv Z, Lv L.
Brain Behav . 2025 Sep;15(9):e70848. doi: 10.1002/brb3.70848.
The causality between chronic rhinosinusitis and inflammatory bowel disease: A bidirectional 2-sample Mendelian randomization analysis
Liu Z, Huang J.
Medicine (Baltimore). 2025 Sep 5;104(36):e44402. doi: 10.1097/MD.0000000000044402.
Bidirectional Mendelian randomization study reveals causal relationships between polymyalgia rheumatica and serum metabolites
Song A, Kang L, Cao S, Wang Y, Li H.
Medicine (Baltimore) . 2025 Sep 5;104(36):e44304. doi: 10.1097/MD.0000000000044304.
A Cross-Tissue Transcriptome-Wide Association Study Identified Susceptibility Genes for Intervertebral Disc Degeneration
Zhang L, Zhao W, Yang H, Deng T, Li Y.
JOR Spine . 2025 Sep 7;8(3):e70109. doi: 10.1002/jsp2.70109. eCollection 2025 Sep.
Revealing the enigmatic interplay between helicobacter pylori infection and biliary system diseases using Mendelian randomization analysis
Zhou J, Wang K, Xu Y, Wang H, Chen C.
Medicine (Baltimore). 2025 Sep 5;104(36):e44290. doi: 10.1097/MD.0000000000044290.
Genetic prediction of the relationship between mitochondrial proteins and diabetic polyneuropathy risk: a Mendelian randomization study
Wang Z, Hu Y, Wei Y, Xue C, Hu Y, Wang Y, Wu C, Jiang F, Wang F.
Endocr Res . 2025 Sep 8:1-10. doi: 10.1080/07435800.2025.2557991.
The Impact of Age at First Sexual Intercourse on Female Reproductive Disorders: A Mendelian Randomized Study
Xin X, Guan L, Li J, Zhang J, Wu H.
Int J Womens Health . 2025 Sep 2:17:2833-2844. doi: 10.2147/IJWH.S534178. eCollection 2025.
Identifying potential therapeutic targets in periodontitis: a multi-omics approach integrating bulk and single-cell RNA sequencing with Mendelian randomization
Zhou H, Chen R, Deng Z, Li S.
Naunyn Schmiedebergs Arch Pharmacol . 2025 Sep 9. doi: 10.1007/s00210-025-04580-3.
Multi-omic insights into mitochondrial dysfunction and prostatic disease: evidence from transcriptomics, proteomics, and methylomics
Gong B, Yang F, Zhang N, Wu Z, Liu T, Wang K, Zhang X, Zhang Y, Song Z, Liang C.
Front Genet . 2025 Aug 22:16:1609933. doi: 10.3389/fgene.2025.1609933. eCollection 2025.
Hidradenitis suppurativa is an HLA-associated autoimmune disease
Zierer J, Cojean C, Osinga R, Läuchli S, Wieczorek G, Roth L, Roediger B.
J Invest Dermatol . 2025 Sep 4:S0022-202X(25)02412-1. doi: 10.1016/j.jid.2025.08.035.
Childhood Obesity Raises GDM Risk Through Adult Obesity: Evidence From Lifecourse Mendelian Randomization Study
Zhang Y, Lin Z, He X, Lu J, Tan P, Huang Q, Zhang K.
Am J Hypertens . 2025 Aug 16:hpaf154. doi: 10.1093/ajh/hpaf154.
Unlocking New Treatment Horizons for Celiac Disease: PRKCD Revealed as a Promising Target through Mendelian Randomization
Zhou J, Xu Y, Wang H, Wang K, Chen C.
Endocr Metab Immune Disord Drug Targets . 2025 Aug 29. doi: 10.2174/0118715303410531250815124524.
Multi-ancestry genome-wide association study of endometriosis and its clinical manifestations in ∼1.4 million women: translating gene discovery into pathogenic mechanisms and therapeutic targets
Dora Koller, Jun He, Solveig Løkhammer, Selena Aranda, Dan Qiu, David Davtian, Qianyu Chen, Ziang Xu, Zhongzheng Mao, Eleni Friligkou, Sefayet Karaca, Bru Cormand, Idhaliz Flores, Signe Altmäe, Marina Mitjans, Brenda Cabrera-Mendoza, Renato Polimanti
medRxiv 2025.09.03.25335012; doi: https://doi.org/10.1101/2025.09.03.25335012
Dietary antioxidants: a challenge or an opportunity for asthma? Genetic insights from a Two-sample mendelian randomization study
Zhou X, Zhou Y, Chen J, Chen C, Chen R, Zheng S, Wang Z, Zhou L.
J Asthma . 2025 Sep 8:1-11. doi: 10.1080/02770903.2025.2555297.
Association Between Socioeconomic Status and Major Congenital Anomalies: A Two-Sample Mendelian Randomization Study
Linares D, Miao Q, Luna B.
Birth Defects Res . 2025 Sep;117(9):e2524. doi: 10.1002/bdr2.2524.
Causal Associations Between Oral Microbiota and Gestational Diabetes Mellitus: A Two-Sample Mendelian Randomization Study
Jin H, Wang Y, Li H, Cheng Y, Ma Y.
Int J Womens Health . 2025 Aug 30:17:2777-2791. doi: 10.2147/IJWH.S531088. eCollection 2025.
Causal effects of lung function and COPD on functional outcome following ischemic stroke: a univariable and multivariable Mendelian randomization study
Wan-ting Sun, Juan Wang, Zhuo-ya Yao, Fang Pan, Zhao-dan Gan, Yun Yang, Jun Lu, Long-yun Zhou, Guang-xu Xu
medRxiv 2025.09.03.25335062; doi: https://doi.org/10.1101/2025.09.03.25335062
Unlocking the Secrets: Causal Associations Between Blood Metabolites and Aspergillosis
Youzhen Ma, Wenlong Du
Curr Microbiol 82, 490 (2025). https://doi.org/10.1007/s00284-025-04465-x
The impact of polygenic score and socioeconomic status in predicting risk for 19 complex diseases
Fiona A. Hagenbeek, Anne Richmond, Max Tamlander, Kira Detrois, Zhiyu Yang, Tuomo Hartonen, Daniel L. McCartney, FinnGen, Riccardo E. Marioni, Pekka Martikainen, Nina Mars, Andrea Ganna, Samuli Ripatti
medRxiv 2025.09.02.25334913; doi: https://doi.org/10.1101/2025.09.02.25334913
Trajectory and genetic correlation mapping of cross-disease risks following incident type 2 inflammatory diseases
Yask Gupta, Henning Olbrich, Diamant Thaci, Philip Curman, Ralf J. Ludwig
medRxiv 2025.09.02.25334921; doi: https://doi.org/10.1101/2025.09.02.25334921
Association Between Platelet Indices and Risk of Chronic Obstructive Pulmonary Disease: A Bidirectional Mendelian Randomization Study
Liao W, Lin X, Liu K, Yang Y, Du L, Pan J, Chen F, Ye W, Chen B, Chen R, Chen W, Yao W.
Int J Chron Obstruct Pulmon Dis . 2025 Aug 27:20:2967-2977. doi: 10.2147/COPD.S531797. eCollection 2025.
Causal relationship between vitamin D and adult height: A bidirectional Mendelian randomization study
Chen L, Wu M, Zeng Z, Hu X, Wang Y.
Medicine (Baltimore) . 2025 Aug 29;104(35):e44123. doi: 10.1097/MD.0000000000044123.
Multiple Sclerosis Drives Gastric Cancer via Shared Inflammatory Pathways: A Mendelian Randomization Study
Hengyi Liao, Xuhao Wang, Yiji Zhang, Zhiya Zhang, Yin Liao
medRxiv 2025.09.01.25334880; doi: https://doi.org/10.1101/2025.09.01.25334880
Preeclampsia, gestational hypertension, and cardiovascular disease risk: a genetic epidemiological study
Taageby Nielsen S, Luo J, Tybjærg-Hansen A, Iversen K, Bundgaard H, Qvist Thomassen J, Frikke-Schmidt R.
Eur Heart J . 2025 Sep 3:ehaf565. doi: 10.1093/eurheartj/ehaf565.
Association between diabetes mellitus and adhesive capsulitis of shoulder: A 2-sample Mendelian randomization study
Li W, Lou J, Huangfu W, Han D.
Medicine (Baltimore) . 2025 Aug 29;104(35):e44119. doi: 10.1097/MD.0000000000044119.