På den här sidan listar vi alla vetenskapliga publikationer som har använt data från FinnGen-studien.

2022

November

Whole-exome sequencing study identifies rare variants and genes associated with intraocular pressure and glaucoma
Gao, X.R., Chiariglione, M. & Arch, A.J.
Nat Commun 13, 7376 (2022). https://doi.org/10.1038/s41467-022-35188-3
Sex differences in coronary artery bypass grafting-related morbidity and mortality
Nurkkala J, Kauko A, Palmu J, Aittokallio J, Niiranen T.
Front Cardiovasc Med. 2022 Nov 29;9:1021363. doi: 10.3389/fcvm.2022.1021363.
Extensive germline-somatic interplay contributes to prostate cancer progression through HNF1B co-option of TMPRSS2-ERG
Giannareas N, Zhang Q, Yang X, Na R, Tian Y, Yang Y, Ruan X, Huang D, Yang X, Wang C, Zhang P, Manninen A, Wang L, Wei GH.
Nat Commun. 2022 Nov 28;13(1):7320. doi: 10.1038/s41467-022-34994-z.
Body mass index and the risk of abdominal hernia: a Mendelian randomization study
Li Z, Xia L, Li X, Guan Y, He H, Jin L.
Hernia. 2022 Nov 28. doi: 10.1007/s10029-022-02703-w.
The causal relationship between psoriasis, psoriatic arthritis, and inflammatory bowel diseases
Sun, Y., Li, Y. & Zhang, J.
Sci Rep 12, 20526 (2022). https://doi.org/10.1038/s41598-022-24872-5
Targeted Resequencing of Otosclerosis Patients from Different Populations Replicates Results from a Previous Genome-Wide Association Study.
Tavernier, L.J.M.; Vanpoucke, T.; Schrauwen, I.; Van Camp, G.; Fransen, E.
J. Clin. Med. 2022, 11, 6978. https://doi.org/10.3390/jcm11236978
Associations of Genetically Predicted Vitamin B12 Status across the Phenome
Dib, M.-J.; Ahmadi, K.R.; Zagkos, L.; Gill, D.; Morris, B.; Elliott, P.; Dehghan, A.; Tzoulaki, I.
Nutrients 2022, 14, 5031. https://doi.org/10.3390/nu14235031
Tea intake and risk of kidney stones: A mendelian randomization study
Liu D, Wang J, Chen Y, Liu F, Deng Y, Wang M.
Nutrition. 2022 Nov 25;107:111919. doi: 10.1016/j.nut.2022.111919.
Causal effects of B vitamins and homocysteine on obesity and musculoskeletal diseases: A Mendelian randomization study
Fu L, Wang Y, Hu YQ.
Front Nutr. 2022 Nov 24;9:1048122. doi: 10.3389/fnut.2022.1048122.
Health effects of milk consumption: phenome-wide Mendelian randomization study
Yuan S, Sun J, Lu Y, Xu F, Li D, Jiang F, Wan Z, Li X, Qin LQ, Larsson SC.
BMC Med. 2022 Nov 23;20(1):455. doi: 10.1186/s12916-022-02658-w.
Whole-exome sequencing identifies novel protein-altering variants associated with serum apolipoprotein and lipid concentrations
Sandholm N, Hotakainen R, Haukka JK, Jansson Sigfrids F, Dahlström EH, Antikainen AA, Valo E, Syreeni A, Kilpeläinen E, Kytölä A, Palotie A, Harjutsalo V, Forsblom C, Groop PH; FinnDiane Study Group.
Genome Med. 2022 Nov 23;14(1):132. doi: 10.1186/s13073-022-01135-6.
White blood cells and chronic rhinosinusitis: a Mendelian randomization study
Pongdee T, Bielinski SJ, Decker PA, Kita H, Larson NB.
Allergy Asthma Clin Immunol. 2022 Nov 22;18(1):98. doi: 10.1186/s13223-022-00739-2.
Is anxiety a pathway to Alcohol Use Disorders? A phenome-wide association study of the GABRA2 coding variant rs279858
Merikangas AK, Kember RL, Plawecki MH, Kamarajan C, Chan G, Bauer L, Meyers JL, Nurnberger JI Jr, Kramer J, Porjesz B, Edenberg HJ, Almasy L.
medRxiv 2022.11.21.22282301; doi: https://doi.org/10.1101/2022.11.21.22282301
Mendelian Randomization Indicates a Causal Role for Omega-3 Fatty Acids in Inflammatory Bowel Disease
Astore C, Nagpal S, Gibson G.
Int. J. Mol. Sci. 2022, 23(22), 14380; https://doi.org/10.3390/ijms232214380
Glucocorticoids unmask silent non-coding genetic risk variants for common diseases
Nguyen TTL, Gao H, Liu D, Philips TJ, Ye Z, Lee JH, Shi GX, Copenhaver K, Zhang L, Wei L, Yu J, Zhang H, Barath A, Luong M, Zhang C, Gaspar-Maia A, Li H, Wang L, Ordog T, Weinshilboum RM.
Nucleic Acids Res. 2022 Nov 11;50(20):11635-11653. doi: 10.1093/nar/gkac1045.
Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes
Nag A, Dhindsa RS, Mitchell J, Vasavda C, Harper AR, Vitsios D, Ahnmark A, Bilican B, Madeyski-Bengtson K, Zarrouki B, Zoghbi AW, Wang Q, Smith KR, Alegre-Díaz J, Kuri-Morales P, Berumen J, Tapia-Conyer R, Emberson J, Torres JM, Collins R, Smith DM, Challis B, Paul DS, Bohlooly-Y M, Snowden M, Baker D, Fritsche-Danielson R, Pangalos MN, Petrovski S.
Sci Adv. 2022 Nov 18;8(46):eadd5430. doi: 10.1126/sciadv.add5430
Genetic predisposition of both waist circumference and hip circumference increased the risk of venous thromboembolism
Wang J, Tan JS, Hua L, Sheng Q, Huang X, Liu P.
Thromb Haemost. 2022 Nov 16. doi: 10.1055/a-1980-8852.
Circulating lipoprotein(a) levels and health outcomes: Phenome-wide Mendelian randomization and disease-trajectory analyses
Larsson SC, Wang L, Li X, Jiang F, Chen X, Mantzoros CS.
Metabolism. 2022 Nov 15;137:155347. doi: 10.1016/j.metabol.2022.155347.
Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study
Li P, Wang H, Guo L, Gou X, Chen G, Lin D, Fan D, Guo X, Liu Z.
BMC Med. 2022 Nov 15;20(1):443. doi: 10.1186/s12916-022-02657-x.
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure
Levin MG, Tsao NL, Singhal P, Liu C, Vy HMT, Paranjpe I, Backman JD, Bellomo TR, Bone WP, Biddinger KJ, Hui Q, Dikilitas O, Satterfield BA, Yang Y, Morley MP, Bradford Y, Burke M, Reza N, Charest B; Regeneron Genetics Center, Judy RL, Puckelwartz MJ, Hakonarson H, Khan A, Kottyan LC, Kullo I, Luo Y, McNally EM, Rasmussen-Torvik LJ, Day SM, Do R, Phillips LS, Ellinor PT, Nadkarni GN, Ritchie MD, Arany Z, Cappola TP, Margulies KB, Aragam KG, Haggerty CM, Joseph J, Sun YV, Voight BF, Damrauer SM.
Nat Commun. 2022 Nov 14;13(1):6914. doi: 10.1038/s41467-022-34216-6.
Evaluating the role of non-alcoholic fatty liver disease in cardiovascular diseases and type 2 diabetes: a Mendelian randomization study in Europeans and East Asians
Au Yeung SL, Borges MC, Wong THT, Lawlor DA, Schooling CM.
Int J Epidemiol. 2022 Nov 11:dyac212. doi: 10.1093/ije/dyac212.
A genetic association study reveals the relationship between the oral microbiome and anxiety and depression symptoms
Li C, Chen Y, Wen Y, Jia Y, Cheng S, Liu L, Zhang H, Pan C, Zhang J, Zhang Z, Yang X, Meng P, Yao Y, Zhang F.
Front Psychiatry. 2022 Nov 10;13:960756. doi: 10.3389/fpsyt.2022.960756.
Independent Associations of Education, Intelligence, and Cognition With Hypertension and the Mediating Effects of Cardiometabolic Risk Factors: A Mendelian Randomization Study
Wang Y, Ye C, Kong L, Zheng J, Xu M, Xu Y, Li M, Zhao Z, Lu J, Chen Y, Wang W, Ning G, Bi Y, Wang T.
Hypertension. 2022 Nov 10. doi: 10.1161/HYPERTENSIONAHA.122.20286.
Causal associations between CD40/CD40L and aortic diseases: A mendelian randomization study
Cui X, Xuan T, Chen S, Guo X.
Front Genet. 2022 Nov 9;13:998525. doi: 10.3389/fgene.2022.998525.
Vascular endothelial growth factor and the risk of venous thromboembolism: a genetic correlation and two-sample Mendelian randomization study
Zhang Q, Zhang X, Zhang J, Wang B, Tian Q, Meng X, Zhang J, Jiang M, Zhang Y, Zheng D, Wu L, Wang W, Wang B, Wang Y.
Thromb J. 2022 Nov 8;20(1):67. doi: 10.1186/s12959-022-00427-6.
Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity
Kristin Tsuo, Wei Zhou, Ying Wang, Masahiro Kanai, Shinichi Namba, Rahul Gupta, Lerato Majara, Lethukuthula L. Nkambule, Takayuki Morisaki, Yukinori Okada, Benjamin M. Neale, Global Biobank Meta-analysis Initiative, Mark J. Daly, Alicia R. Martin
Cell Genomics Nov 08, 2022, DOI:https://doi.org/10.1016/j.xgen.2022.100212
Systematic comparison of family history and polygenic risk across 24 common diseases
Mars N, Lindbohm JV, Della Briotta Parolo P, Widén E, Kaprio J, Palotie A; FinnGen, Ripatti S.
Am J Hum Genet. 2022 Nov 3:S0002-9297(22)00457-8. doi: 10.1016/j.ajhg.2022.10.009.
Milk consumption and risk of twelve cancers: A large-scale observational and Mendelian randomisation study
Lumsden AL, Mulugeta A, Hyppönen E.
Clin Nutr. 2022 Nov 7;42(1):1-8. doi: 10.1016/j.clnu.2022.11.006.
Plasma phospholipid arachidonic acid in relation to non-alcoholic fatty liver disease: Mendelian randomization study
Chen J, Ruan X, Sun Y, Li X, Yuan S, Larsson SC.
Nutrition. 2022 Nov 6;106:111910. doi: 10.1016/j.nut.2022.111910.
No evidence for a causal link between Helicobacter pylori infection and nonalcoholic fatty liver disease: A bidirectional Mendelian randomization study
Liu Y, Xu H, Zhao Z, Dong Y, Wang X, Niu J.
Front Microbiol. 2022 Nov 3;13:1018322. doi: 10.3389/fmicb.2022.1018322.
The causal association between iron status and the risk of autism: A Mendelian randomization study
Chen L, Guo X, Hou C, Tang P, Zhang X, Chong L, Li R.
Front Nutr. 2022 Nov 3;9:957600. doi: 10.3389/fnut.2022.957600.
The Identification of Significant Genes Related to Systemic Lupus Erythematosus through the Integration of the Results of a Transcriptome-Wide Association Study and an mRNA Expression Profile Analysis
Shuai Li, Jiawen Xu, Ye Tian, Yi Zeng, Haibo Si, Yuangang Wu, Shaoyun Zhang, Bin Shen
Researchsquare, 31 July 2023, doi: 10.21203/rs.3.rs-2216395/v1
Assessing the causal role of hypertension on left atrial and left ventricular structure and function: A two-sample Mendelian randomization study
Sun Y, Zhang Y, Xu N, Bi C, Liu X, Song W, Jiang Y.
Front Cardiovasc Med. 2022 Nov 2;9:1006380. doi: 10.3389/fcvm.2022.1006380.
Genetic estimation of correlations and causalities between multifaceted modifiable factors and gastro-oesophageal reflux disease
Sun Y, Cao X, Cao D, Cui Y, Su K, Jia Z, Wu Y, Jiang J.
Front Nutr. 2022 Nov 1;9:1009122. doi: 10.3389/fnut.2022.1009122.

Oktober

Causal relationship between obesity, lifestyle factors and risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization study
Wang YB, Yang L, Deng YQ, Yan SY, Luo LS, Chen P, Zeng XT.
J Transl Med. 2022 Oct 29;20(1):495. doi: 10.1186/s12967-022-03722-y.
Causal Relationships of Excessive Daytime Napping with Atherosclerosis and Cardiovascular Diseases: A Mendelian Randomization Study
Chen J, Chen J, Zhu T, Fu Y, Cheongi IH, Yi K, Wang H, Li X.
Sleep. 2022 Oct 27:zsac257. doi: 10.1093/sleep/zsac257.
The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α
Chandra V, Ibrahim H, Halliez C, Prasad RB, Vecchio F, Dwivedi OP, Kvist J, Balboa D, Saarimäki-Vire J, Montaser H, Barsby T, Lithovius V, Artner I, Gopalakrishnan S, Groop L, Mallone R, Eizirik DL, Otonkoski T.
Nat Commun. 2022 Oct 26;13(1):6363. doi: 10.1038/s41467-022-34069-z.
Genome-wide association study meta-analysis supports association between MUC1 and ectopic pregnancy
Pujol Gualdo N; Estonian Biobank Research Team; Mägi R, Laisk T
Hum Reprod. 2023 Oct 24:dead217. doi: 10.1093/humrep/dead217
Role of Inflammatory Factors in Mediating the Effect of Lipids on Nonalcoholic Fatty Liver Disease: A Two-Step, Multivariable Mendelian Randomization Study
Chen J, Zhou H, Jin H, Liu K.
Nutrients. 2022 Oct 21;14(20):4434. doi: 10.3390/nu14204434.
Mendelian randomization study updates the effect of hypertension on the risk of primary open-angle glaucoma
Qing Chen, Jian He, Shuting Yang, lili lian, Zhenzhen Wang, Shuwen Zhang, Zhenmin Le, Binge Huang, Qinxiang Zheng, Cong Ye, Yueping Ren
Researchsquare, 19 October 2022, doi:10.21203/rs.3.rs-2123486/v1
Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study
Nethander M, Coward E, Reimann E, Grahnemo L, Gabrielsen ME, Wibom C; Estonian Biobank Research Team, Mägi R, Funck-Brentano T, Hoff M, Langhammer A, Pettersson-Kymmer U, Hveem K, Ohlsson C.
Cell Rep Med. 2022 Oct 18;3(10):100776. doi: 10.1016/j.xcrm.2022.100776.
Genome-wide association study meta-analysis of suicide death and suicidal behavior
Li QS, Shabalin AA, DiBlasi E, Gopal S, Canuso CM; FinnGen, International Suicide Genetics Consortium, Palotie A, Drevets WC, Docherty AR, Coon H
Mol Psychiatry. 2022 Oct 17. doi: 10.1038/s41380-022-01828-9
Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases
Gagnon E, Pelletier W, Gobeil É, Bourgault J, Manikpurage HD, Maltais-Payette I, Abner E, Taba N, Esko T, Mitchell PL, Ghodsian N, Després JP, Vohl MC, Tchernof A, Thériault S, Arsenault BJ.
Commun Med (Lond). 2022 Oct 13;2:130. doi: 10.1038/s43856-022-00196-3.
Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis genetics
Partanen JJ, Häppölä P, Zhou W, Lehisto AA, Ainola M, Sutinen E, Allen RJ, Stockwell AD, Leavy OC, Oldham JM, Guillen-Guio B, Nancy J. Cox N.J.,Hirbo J.B., Schwartz D.A., Fingerlin T.A. ,Flores C, Noth I, Yaspan BL, Jenkins RG, Wain LV, Ripatti S, Pirinen M, International IPF Genetics Consortium, Global Biobank Meta-analysis Initiative (GBMI), Laitinen T, Kaarteenaho R, Myllärniemi M, Daly MJ, Koskela JT.
Cell Genomics vol 2, issue 10, 100181, Oct 12, 2022. DOI:https://doi.org/10.1016/j.xgen.2022.100181
Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases
Zhao H, Rasheed H, Nøst TH, Cho Y, Liu Y, Bhatta L, Bhattacharya A; Global Biobank Meta-analysis Initiative; Hemani G, Davey Smith G, Brumpton BM, Zhou W, Neale BM, Gaunt TR, Zheng J.
Cell Genom. 2022 Nov 9;2(11):None. doi: 10.1016/j.xgen.2022.100195.
Global Biobank Meta-analysis Initiative: powering genetic discovery across human diseases
Zhou W, Kanai M, Wu K-HH, Humaira R, Tsuo K, Hirbo JB, Wang Y, Bhattacharya A, Zhao H, Namba S, Surakka I, Wolford BN, Lo Faro V, Lopera-Maya EA, Läll K, Favé M-J, Chapman SB, Karjalainen J, Kurki M, Mutaamba M, Brumpton BM, Chavan S, Chen T-T, Daya M, Ding Y, Feng Y-CA, Gignoux CR, Graham SE, Hornsby WE, Ingold N, Johnson R, Laisk T, Lin K, Lv J, Millwood IY, Palta P, Pandit A, Preuss M, Thorsteinsdottir U, Uzunovic J, Zawistowski MW, Zhong X, Campbell A, Crooks K, De Bock GH, Douville NJ, Finer S, Fritsche LG, Griffiths CJ, Guo Y, Hunt KA, Konuma T, Marioni RE, Nomdo J, Patil S, Rafaels N, Richmond A, Shortt JA, Straub P, Tao R, Vanderwerff B, Barnes KC, Boezen M, Chen Z, Chen C-Y, Cho J, Davey Smith G, Finucane HK, Franke L, Gamazon E, Ganna A, Gaunt TR, Ge T, Huang H, Huffman J, Lajonchere C, Law MH, Li L, Lindgren CM, Loos RJF, MacGregor S, Matsuda K, Olsen CM, Porteous DJ, Shavit JA, Snieder H, Trembath RC, Vonk JM, Whiteman D, Wicks SJ, Wijmenga C, Wright J, Zheng J, Zhou X, Awadalla P, Boehnke M, Cox NJ, Geschwind DH, Hayward C, Hveem K, Kenny EE, Lin Y-F, Mägi R, Martin HC, Medland SE, Okada Y, Palotie AV, Pasaniuc B, Sanna S, Smoller JW, Stefansson K, van Heel DA, Walters RG, Zoellner S, Biobank Japan, BioMe, BioVU, Canadian Partnership for Tomorrow, China Kadoorie Biobank Collaborative Group, Colorado Center for Personalized Medicine, deCODE Genetics, Estonian Biobank, FinnGen, Generation Scotland, Genes & Health, LifeLines, Mass General Brigham Biobank, Michigan Genomics Initiative, QIMR Berghofer Biobank, Taiwan Biobank, The HUNT Study, UCLA ATLAS Community Health Initiative, UK Biobank, Martin AR, Willer CJ, Daly MJ, Neale BM.
Cell Genomics vol 2, issue 10, 100192, Oct 12, 2022. DOI:https://doi.org/10.1016/j.xgen.2022.100192
Plasma lipid levels and risk of retinal vascular occlusion: A genetic study using Mendelian randomization
Zheng C, Lin Y, Jiang B, Zhu X, Lin Q, Luo W, Tang M, Xie L.
Front Endocrinol (Lausanne). 2022 Oct 10;13:954453. doi: 10.3389/fendo.2022.954453.
Mendelian randomization in blood metabolites identifies triglycerides and fatty acids saturation level as associated traits linked to pancreatitis risk
Mi J, Liu Z, Jiang L, Li M, Wu X, Zhao N, Wan Z, Bai X, Feng Y.
Front Nutr. 2022 Oct 10;9:1021942. doi: 10.3389/fnut.2022.1021942.
Genetic risk, incident colorectal cancer, and the benefits of adhering to a healthy lifestyle: A prospective study using data from UK Biobank and FinnGen
Wu E, Ni JT, Chen X, Zhu ZH, Xu HQ, Tao L, Xie T.
Front Oncol. 2022 Oct 6;12:894086. doi: 10.3389/fonc.2022.894086.
Genetically predicted phosphate and cardiovascular disease: A Mendelian randomization study
Huang J, Zhang C, Gong Q, Gao Y, Xie X, Jiang J.
Front Cardiovasc Med. 2022 Oct 5;9:973338. doi: 10.3389/fcvm.2022.973338.