På den här sidan listar vi alla vetenskapliga publikationer som har använt data från FinnGen-studien.

2023

Mars

Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis
Lin J, Zhou J, Xu Y.
Brain. 2023 Mar 2:awad070. doi: 10.1093/brain/awad070.
Genetic Association between the Levels of Plasma Lipids and the Risk of Aortic Aneurysm and Aortic Dissection: A Two-Sample Mendelian Randomization Study
Li R, Zhang C, Du X, Chen S.
J Clin Med. 2023 Mar 2;12(5):1991. doi: 10.3390/jcm12051991.
Statins and risk of venous thromboembolic diseases: A two-sample mendelian randomization study
Ma XS, Sun J, Geng R, Zhao Y, Xu WZ, Liu YH, Jiang YN, Li YQ.
Nutr Metab Cardiovasc Dis. 2023 Mar 2:S0939-4753(23)00083-2. doi: 10.1016/j.numecd.2023.02.023.
Effect of tissue-grouped regulatory variants associated to type 2 diabetes in related secondary outcomes
Hemerich D, Smit RAJ, Preuss M, Stalbow L, van der Laan SW, Asselbergs FW, van Setten J, Tragante V.
Sci Rep. 2023 Mar 2;13(1):3579. doi: 10.1038/s41598-023-30369-6.
Apparent Treatment Resistant Hypertension Associated Lifetime Cardiovascular Risk in a Longitudinal National Registry
Ebinger JE, Kauko A; FinnGen; Bello NA, Cheng S, Niiranen T.
Eur J Prev Cardiol. 2023 Mar 2:zwad066. doi: 10.1093/eurjpc/zwad066.
C9orf72 hexanucleotide repeat allele tagging SNPs: Associations with ALS risk and longevity
Kaivola K, Pirinen M, Laaksovirta H, Jansson L, Rautila O, Launes J, Hokkanen L, Lahti J, Eriksson JG, Strandberg TE, FinnGen, Tienari PJ.
Front Genet. 2023 Mar 1;14:1087098. doi: 10.3389/fgene.2023.1087098.
Causal effect of psychiatric disorders on epilepsy: A two-sample Mendelian randomization study
Li G, Wang M, Zheng M, Liu X, Yu T, Ren J, Wang Q.
Brain Behav. 2023 Mar 1:e2939. doi: 10.1002/brb3.2939.
Associations of polygenic risk scores for preeclampsia and blood pressure with hypertensive disorders of pregnancy
Nurkkala J, Kauko A, FinnGen, Laivuori H, Saarela T, Tyrmi JS, Vaura F, Cheng S, Bello NA, Aittokallio J, Niiranen T.
J Hypertens. 2023 Mar 1;41(3):380-387. doi: 10.1097/HJH.0000000000003336.

Februari

Genetic liability to mental disorders in relation to the risk of hypertension
Huangfu N, Lu Y, Ma H, Hu Z, Cui H, Yang F.
Front Cardiovasc Med. 2023 Feb 27;10:1087251. doi: 10.3389/fcvm.2023.1087251.
Causal Association of Inflammatory Bowel Disease on Anorexia Nervosa: a Two-Sample Mendelian Randomization Study
Jiang R, Zeng R, Xinqi Q, Wu H, Zhuo Z, Yang Q, Li J, Leung FW, Lian Q, Sha W, Chen H.
Int J Ment Health Addiction (2023). https://doi.org/10.1007/s11469-023-01033-x
Roles of gut microbiome in epilepsy risk: A Mendelian randomization study
Zeng Y, Cao S, Yang H.
Front Microbiol. 2023 Feb 27;14:1115014. doi: 10.3389/fmicb.2023.1115014.
Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses
Chen J, Xu F, Ruan X, Sun J, Zhang Y, Zhang H, Zhao J, Zheng J, Larsson SC, Wang X, Li X, Yuan S.
EBioMedicine. 2023 Mar;89:104494. doi: 10.1016/j.ebiom.2023.104494.
Sphingolipids are depleted in alcohol-related liver fibrosis
Thiele M, Suvitaival T, Trošt K, Kim M, de Zawadzki A, Kjaergaard M, Rasmussen DN, Lindvig KP, Israelsen M, Detlefsen S, Andersen P, Juel HB, Nielsen T, Georgiou S, Filippa V, Kuhn M, Nishijima S, Moitinho-Silva L, Rossing P, Trebicka J, Anastasiadou E, Bork P, Hansen T, Quigley CL, Krag A; MicrobLiver; GALAXY Consortia.
Gastroenterology. 2023 Feb 25:S0016-5085(23)00162-2. doi: 10.1053/j.gastro.2023.02.023.
Association between Dietary Habits and Pancreatitis among Individuals of European Ancestry: A Two-Sample Mendelian Randomization Study
Mao X, Huang C, Wang Y, Mao S, Li Z, Zou W, Liao Z.
Nutrients. 2023 Feb 24;15(5):1153. doi: 10.3390/nu15051153.
Constipation and cardiovascular disease: A two-sample Mendelian randomization analysis
Dong Q, Chen D, Zhang Y, Xu Y, Yan L, Jiang J.
Front Cardiovasc Med. 2023 Feb 24;10:1080982. doi: 10.3389/fcvm.2023.1080982.
Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases
Yuan S, Wang L, Zhang H, Xu F, Zhou X, Yu L, Sun J, Chen J, Ying H, Xu X, Yu Y, Spiliopoulou A, Shen X, Wilson J, Gill D, Theodoratou E, Larsson SC, Li X.
EBioMedicine. 2023 Mar;89:104488. doi: 10.1016/j.ebiom.2023.104488.
Distilling functional variations for human UGT2B4 upstream region based on selection signals and implications for phenotypes of Neanderthal and Denisovan
Wang PY, Yang Y, Shi XQ, Chen Y, Liu SD, Wang HY, Peng T, Shi Q, Zhang W, Sun C.
Sci Rep. 2023 Feb 23;13(1):3134. doi: 10.1038/s41598-023-29682-x.
Inflammatory markers and the risk of idiopathic sudden sensorineural hearing loss: A Mendelian randomization study
Zhou T, Chen M, Yuan Z, Xia Z, Zhang S, Zhang Z, Chen H, Lin R.
Front Neurol. 2023 Feb 22;14:1111255. doi: 10.3389/fneur.2023.1111255.
Type 2 diabetes and glycemic traits are not causal factors of delirium: A two-sample mendelian randomization analysis
Li J, Yang M, Luo P, Wang G, Dong B, Xu P.
Front Genet. 2023 Feb 21;14:1087878. doi: 10.3389/fgene.2023.1087878.
Genetic Risk of Primary Aldosteronism and Its Contribution to Hypertension: A Cross-Ancestry Meta-Analysis of Genome-Wide Association Study
Naito T, Inoue K, Sonehara K, Baba R, Kodama T, Otagaki Y, Okada A, Itcho K, Kobuke K, Kishimoto S, Yamamoto K; BioBank Japan; Morisaki T, Higashi Y, Hinata N, Arihiro K, Hattori N, Okada Y, Oki K.
Circulation. 2023 Feb 21. doi: 10.1161/CIRCULATIONAHA.122.062349.
Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study
Long Y, Tang L, Zhou Y, Zhao S, Zhu H.
BMC Med. 2023 Feb 21;21(1):66. doi: 10.1186/s12916-023-02761-6.
The hepato-ovarian axis: genetic evidence for a causal association between non-alcoholic fatty liver disease and polycystic ovary syndrome
Liu D, Gao X, Pan XF, Zhou T, Zhu C, Li F, Fan JG, Targher G, Zhao J.
BMC Med. 2023 Feb 20;21(1):62. doi: 10.1186/s12916-023-02775-0.
No Evidence of a Genetic Causal Relationship between Ankylosing Spondylitis and Gut Microbiota: A Two-Sample Mendelian Randomization Study
Yang M, Wan X, Zheng H, Xu K, Xie J, Yu H, Wang J, Xu P.
Nutrients. 2023 Feb 20;15(4):1057. doi: 10.3390/nu15041057.
An observational and Mendelian randomisation study on iron status and sepsis
Hamilton F, Mitchell R, Ahmed H, Ghazal P, Timpson NJ.
Sci Rep 13, 2867 (2023). https://doi.org/10.1038/s41598-023-29641-6.
Association of Hypertensive Disorders of Pregnancy With Future Cardiovascular Disease
Rayes B, Ardissino M, Slob EAW, Patel KHK, Girling J, Ng FS.
JAMA Netw Open. 2023 Feb 1;6(2):e230034. doi: 10.1001/jamanetworkopen.2023.0034.
Gastrointestinal Consequences of Type 2 Diabetes Mellitus and Impaired Glycemic Homeostasis: A Mendelian Randomization Study
Chen J, Yuan S, Fu T, Ruan X, Qiao J, Wang X, Li X, Gill D, Burgess S, Giovannucci EL, Larsson SC.
Diabetes Care. 2023 Feb 17:dc221385. doi: 10.2337/dc22-1385.
Phenome-wide investigation of the causal associations of cheese intake with obesity and obesity traits: a two-sample mendelian randomization analyses
Yu-qing HUANG, Ze HUANG, Guo HE, Ying FENG
Researchsquare, 15 February 2023, doi: 10.21203/rs.3.rs-2541652/v1
Causal relationship between atrial fibrillation and leukocyte telomere length: A two sample, bidirectional Mendelian randomization study
Sha Z, Hou T, Zhou T, Dai Y, Bao Y, Jin Q, Ye J, Lu Y, Wu L.
Front Cardiovasc Med. 2023 Feb 15;10:1093255. doi: 10.3389/fcvm.2023.1093255.
LAVAA: a lightweight association viewer across ailments
Fauman EB, Keppo S, Cerioli N, Vyas R, Kurki M, Daly M, Reeve MP.
Bioinform Adv. 2023 Feb 15;3(1):vbad018. doi: 10.1093/bioadv/vbad018.
Processed meat, red meat, white meat, and digestive tract cancers: A two-sample Mendelian randomization study
Yun Z, Nan M, Li X, Liu Z, Xu J, Du X, Dong Q, Hou L.
Front Nutr. 2023 Feb 13;10:1078963. doi: 10.3389/fnut.2023.1078963.
Mendelian randomization study shows a causal effect of asthma on epilepsy risk
Tang P, Guo X, Chong L, Li R.
Front Immunol. 2023 Feb 13;14:1071580. doi: 10.3389/fimmu.2023.1071580.
Causal Associations of PM2.5 and GDM: A Two-Sample Mendelian Randomization Study
Yang Y, Ma X, Pang W, Jiang C.
Toxics. 2023 Feb 13;11(2):171. doi: 10.3390/toxics11020171.
Causal associations between site-specific cancer and diabetes risk: A two-sample Mendelian randomization study
Xu R, Zheng T, Ouyang C, Ding X, Ge C.
Front Endocrinol (Lausanne). 2023 Feb 13;14:1110523. doi: 10.3389/fendo.2023.1110523.
Effect of gastroesophageal reflux disease on sleep disorders: a Mendelian randomization study
Li Z, Zhuang W, Wu J, Xu H, Tang Y, Qiao Q.
medRxiv 2023.02.11.23285798; doi: https://doi.org/10.1101/2023.02.11.23285798
Increasing serum iron levels and their role in the risk of infectious diseases: a Mendelian randomization approach
Butler-Laporte G, Farjoun Y, Chen Y, Hultström M, Liang KYH, Nakanishi T, Su CY, Yoshiji S, Forgetta V, Richards JB.
Int J Epidemiol. 2023 Feb 11:dyad010. doi: 10.1093/ije/dyad010.
Does Having Rheumatoid Arthritis Increase the Dose of Depression Medications? A Mendelian Randomization Study
Wan X, Xie J, Yang M, Yu H, Hou W, Xu K, Wang J, Xu P.
J Clin Med. 2023 Feb 10;12(4):1405. doi: 10.3390/jcm12041405.
Systemic inflammatory regulators and proliferative diabetic retinopathy: A bidirectional Mendelian randomization study
Shi Q, Wang Q, Wang Z, Lu J, Wang R.
Front Immunol. 2023 Feb 10;14:1088778. doi: 10.3389/fimmu.2023.1088778.
Genetic Predisposition to a Higher Whole Body Water Mass May Increase the Risk of Atrial Fibrillation: A Mendelian Randomization Study
Zhu Q, Chen Q, Tian Y, Zhang J, Ran R, Shu S.
J Cardiovasc Dev Dis. 2023 Feb 10;10(2):76. doi: 10.3390/jcdd10020076.
Association between diverticular disease and colorectal cancer: a bidirectional mendelian randomization study
Zhang Y, Zhang H, Zhu J, He Y, Wang P, Li D, Liu X, Jin W, Zhang J, Xu C, Yu Z, Zhao X, Cui L.
BMC Cancer. 2023 Feb 10;23(1):137. doi: 10.1186/s12885-023-10606-x.
Maladaptive Neuroplasticity in Corticospinal Tract after Ankle Sprain: Causal Links Established by Mendelian Randomization
Xue X, Li Y, Wang Y, Li Q, Xu X, Lu R, Hua Y.
Med Sci Sports Exerc. 2023 Feb 10. doi: 10.1249/MSS.0000000000003134.
Pancreatic microexons regulate islet function and glucose homeostasis
Juan-Mateu J, Bajew S, Miret-Cuesta M, Íñiguez LP, Lopez-Pascual A, Bonnal S, Atla G, Bonàs-Guarch S, Ferrer J, Valcárcel J, Irimia M.
Nat Metab. 2023 Feb;5(2):219-236. doi: 10.1038/s42255-022-00734-2.
Mendelian randomization approach shows no causal effects of gestational age on epilepsy in offspring
Guo X, Tang P, Zhang L, Cui J, Li R.
Epilepsy Res. 2023 Feb 9;191:107102. doi: 10.1016/j.eplepsyres.2023.107102.
Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus
Khunsriraksakul C, Li Q, Markus H, Patrick MT, Sauteraud R, McGuire D, Wang X, Wang C, Wang L, Chen S, Shenoy G, Li B, Zhong X, Olsen NJ, Carrel L, Tsoi LC, Jiang B, Liu DJ.
Nat Commun. 2023 Feb 7;14(1):668. doi: 10.1038/s41467-023-36306-5.
Genetic variants associated with syncope implicate neural and autonomic processes
Aegisdottir HM, Thorolfsdottir RB, Sveinbjornsson G, Stefansson OA, Gunnarsson B, Tragante V, Thorleifsson G, Stefansdottir L, Thorgeirsson TE, Ferkingstad E, Sulem P, Norddahl G, Rutsdottir G, Banasik K, Christensen AH, Mikkelsen C, Pedersen OB, Brunak S, Bruun MT, Erikstrup C, Jacobsen RL, Nielsen KR, Sørensen E, Frigge ML, Hjorleifsson KE, Ivarsdottir EV, Helgadottir A, Gretarsdottir S, Steinthorsdottir V, Oddsson A, Eggertsson HP, Halldorsson GH, Jones DA, Anderson JL, Knowlton KU, Nadauld LD; DBDS Genomic Consortium; Haraldsson M, Thorgeirsson G, Bundgaard H, Arnar DO, Thorsteinsdottir U, Gudbjartsson DF, Ostrowski SR, Holm H, Stefansson K.
Eur Heart J. 2023 Feb 7:ehad016. doi: 10.1093/eurheartj/ehad016.
Association between Inflammatory Bowel Disease and Iridocyclitis: A Mendelian Randomization Study
Meng Y, Tan Z, Liu C, Dong W, Chen C.
J Clin Med. 2023 Feb 6;12(4):1282. doi: 10.3390/jcm12041282.
Possible Protective Effects of Uridine on Atrial Fibrillation: A Mendelian Randomization Study
Xintian Xu, Xiaoyu Zhang, Shiyao Cheng, Mao Ouyang
Researchsquare, 06 January 2023, doi:10.21203/rs.3.rs-2436173/v1
The FinnGen study: disease insights from a 'bottlenecked' population
Minton K.
Nat Rev Genet. 2023 Feb 6. doi: 10.1038/s41576-023-00584-y.
Glucagon-like peptide-1 receptor agonists and diabetic retinopathy: nationwide cohort and Mendelian randomization studies
Zheng D, Li N, Hou R, Zhang X, Wu L, Sundquist J, Sundquist K, Ji J.
BMC Med. 2023 Feb 3;21(1):40. doi: 10.1186/s12916-023-02753-6.
Association Between Breakfast Cereals and Risk of Cardiovascular Diseases and Type 2 Diabetes: A Mendelian Randomization Study
Tao Cheng, Shuqing Shi, Xuesong Zhang, Chenglin Duan, Zhangjun Yun, Yuanhui Hu
Researchsquare, 02 February 2023, doi:10.21203/rs.3.rs-2388462/v1
Smoking, Alcohol consumption, and 24 Gastrointestinal Diseases: Mendelian Randomization Analysis
Yuan S, Chen J, Ruan X, Sun Y, Zhang K, Wang X, Li X, Gill D, Burgess S, Giovannucci E, Larsson SC.
Elife. 2023 Feb 2;12:e84051. doi: 10.7554/eLife.84051.