Below you will find all the published and preprint scientific papers using FinnGen data.

2024

August

No Causal Relationship Between Coagulation Factors and Sepsis-Related Risks: A Mendelian Randomization Study
Jingchao Lei, Jing Qi, Jia Zhai, Yao Zhang, Chuanzheng Sun
Researchsquare, 06 August 2024, doi: 10.21203/rs.3.rs-4727406/v1
Mendelian randomization based on immune cells in diabetic nephropathy
Zhou Y, Zhang H, Yan H, Huang C, Liu Y.
Front Endocrinol (Lausanne). 2024 Aug 6;15:1460652. doi: 10.3389/fendo.2024.1460652.
Causal association between Helicobacter pylori infection and Sjogren's syndrome: a bidirectional Mendelian randomization analysis
Cui D, An R, Li L, Jiang L, Jiang C, Jin J.
BMC Infect Dis. 2024 Aug 5;24(1):782. doi: 10.1186/s12879-024-09678-2.
Mendelian randomization analysis identified potential genes pleiotropically associated with gout
Wang Y, Chen J, Yao H, Li Y, Xu X, Zhang D.
Front Genet. 2024 Aug 5;15:1426860. doi: 10.3389/fgene.2024.1426860.
Perspective Exploring Novel Associations of IL-18 Levels as a Mediator of the Causal Links between Major Depression and Reproductive Health
Li M, Sun K, Mei Y, Liu K, Chen L, Guo Y.
Depress Anxiety. 2024 Aug 5;2024:9234876. doi: 10.1155/2024/9234876.
Association between Kidney Stones and CKD: A Bidirectional Mendelian Randomization Study
Zhou LT, Ali AE, Jayachandran M, Haskic Z, Harris PC, Rule AD, Koo K, McDonnell SK, Larson NB, Lieske JC.
J Am Soc Nephrol. 2024 Aug 5. doi: 10.1681/ASN.0000000000000453.
Causal roles of skin microbiota in skin cancers suggested by genetic study
Zhu Y, Liu W, Wang M, Wang X, Wang S.
Front Microbiol. 2024 Aug 5;15:1426807. doi: 10.3389/fmicb.2024.1426807.
Genetic association of lipid and lipid-lowering drug target genes with atopic dermatitis: a drug target Mendelian randomization study
Niu Q, Zhang T, Mao R, Zhao N, Deng S.
Sci Rep. 2024 Aug 5;14(1):18097. doi: 10.1038/s41598-024-69180-2.
Bidirectional two-sample Mendelian randomization analysis identifies causal associations between migraine and five psychiatric disorders
Li WW, Zhang JX, Wang J, Chen YQ, Lai S, Qiu ZK.
Front Neurol. 2024 Aug 5;15:1432966. doi: 10.3389/fneur.2024.1432966.
Relationship between circulating white blood cell count and inflammatory skin disease: a bidirectional mendelian randomization study
Yuan J, Che Y, Wang Q, Xiao Q.
Arch Dermatol Res. 2024 Aug 5;316(8):504. doi: 10.1007/s00403-024-03241-4.
Causal relationship between gut microbiota and vulvar cancer: a two-sample bi-directional Mendelian randomization study
Chen J, Wang P, Xiao C, Kelaimu K, Zeng Y, Lyu F, Gao X, Li X, Hu J.
medRxiv 2024.08.04.24311470; doi: https://doi.org/10.1101/2024.08.04.24311470
Mendelian randomization demonstrates a causal link between peripheral circulating acylcarnitines and intracranial aneurysms
Wang Y, Xie K, Wang J, Chen F, Li X, Zhang L.
Neurotherapeutics. 2024 Aug 3:e00428. doi: 10.1016/j.neurot.2024.e00428.
Exploring the Association Between Gastroesophageal Reflux and Temporomandibular Joint Disorder in European Populations: A Bidirectional Mendelian Randomization Analysis
Gu R, Chen L, Hua M, Miao H, Qin Y.
Int Dent J. 2024 Aug 3:S0020-6539(24)01401-1. doi: 10.1016/j.identj.2024.07.1210.
Causal role of immune cells in aplastic anemia: Mendelian randomization (MR) study
Fu S, Du Y, Pan T, Ma F, He H, Li Y.
Sci Rep. 2024 Aug 3;14(1):18010. doi: 10.1038/s41598-024-69104-0.
Causal effects of gut microbiota on diabetic neuropathy: a two-sample Mendelian randomization study
Xu M, Hao J, Qi Y, Wu B, Li R, Yang X, Zhang Y, Liu Y.
Front Endocrinol (Lausanne). 2024 Aug 2;15:1388927. doi: 10.3389/fendo.2024.1388927.
Exploring the causal relationships between cholelithiasis, cholecystitis, cholecystectomy, and gastroesophageal reflux disease: A bidirectional two-sample mendelian randomization study
Lin H, Lu R, Shang Q, Gu Y, Liu Y, Yang Y, Chen L.
Int J Surg. 2024 Aug 2. doi: 10.1097/JS9.0000000000001992.
Causal effects of endometriosis stages and locations on menstruation, ovulation, reproductive function, and delivery modes: a two-sample Mendelian randomization study
Shen L, Li J, Zhang H, Zhao Y.
Front Endocrinol (Lausanne). 2024 Aug 2;15:1328403. doi: 10.3389/fendo.2024.1328403.
Genetically Proxied Appendicular Lean Mass and Stroke Risk:a Two-step Mendelian Randomization Study
Li Z, Liu X, Wen J, Wang Z, Xie Y, Zhu L, Wu X, Fang C, Tian Y, Li Q.
J Stroke Cerebrovasc Dis. 2024 Aug 2:107915. doi: 10.1016/j.jstrokecerebrovasdis.2024.107915.
Immune thrombocytopenia increases the risk of thrombosis: A two-sample Mendelian randomization study
Yu J, Fu L, Jin G, Gao F, Ding L, Hong L, Lv S, Jin J, Tang L, Feng W, Zhang K, Xu C.
Int J Cardiol. 2024 Aug 2:132417. doi: 10.1016/j.ijcard.2024.132417.
Senescence-related genes and proteins in the development of Alzheimer's disease: evidence from transcriptomic and Mendelian randomization analysis
Liu Y, Chen J.
Front Aging Neurosci. 2024 Aug 2;16:1423725.
Association between gut microbiota and diabetic microvascular complications: a two-sample Mendelian randomization study
Zhou P, Hao Z, Chen Y, Zhang Z, Xu W, Yu J.
Front Endocrinol (Lausanne). 2024 Aug 2;15:1364280. doi: 10.3389/fendo.2024.1364280.
Gastroesophageal reflux disease increases the risk of rheumatoid arthritis: a bidirectional two-sample Mendelian randomization study
Yuan Q, Shen Z, Zhang J, Liu Q, Whang H, Li Y.
Sci Rep. 2024 Aug 1;14(1):17796. doi: 10.1038/s41598-024-64966-w.
Effect of trace elements and nutrients on diabetes and its complications: a Mendelian randomization study
Jia MJ, Chen L.
Front Nutr. 2024 Aug 1;11:1439217. doi: 10.3389/fnut.2024.1439217.
Elucidating the role of genetically determined metabolites in Diabetic Retinopathy: insights from a mendelian randomization analysis
Tan Y, Yan Z, Yin J, Cao J, Xie B, Zhang F, Zhang W, Xiong W.
Acta Diabetol. 2024 Aug 1. doi: 10.1007/s00592-024-02345-7.
Causal relationship between air pollution and infections: a two-sample Mendelian randomization study
Yang S, Tong T, Wang H, Li Z, Wang M, Ni K.
Front Public Health. 2024 Aug 1;12:1409640. doi: 10.3389/fpubh.2024.1409640.
Exploring the causal effect between lipid-modifying drugs and idiopathic pulmonary fibrosis: a drug-target Mendelian randomization study
Cai G, Liu J, Cai M, Shao L.
Lipids Health Dis. 2024 Aug 1;23(1):237. doi: 10.1186/s12944-024-02218-6.
Periodontitis and Chronic Obstructive Pulmonary Disease: A bidirectional Mendelian randomization study
Chen M, Chang S, Xu Y, Zhang L, Guo H, Liu J.
Community Dent Health. 2024 Aug 30;41(3):177-182. doi: 10.1922/CDH_00036Chen06.
The Causal Effect of Serum Lipid Levels Mediated by Neuregulin 4 on the Risk of Four Atherosclerosis Subtypes: Evidence from Mendelian Randomization Analysis
Zheng L, Zhang C, Bu S, Guo W, Li T, Xu Y, Liu Y, Yuan C, Feng C, Zong G, Zhu J, Xing M, Geng X.
Vasc Health Risk Manag. 2024 Aug 1;20:351-357. doi: 10.2147/VHRM.S459075.
Statins inhibit paclitaxel-induced PD-L1 expression and increase CD8+ T cytotoxicity for better prognosis in breast cancer
Li L, Wang H, Zhang S, Gao S, Lu X, Pan Y, Tang W, Huang R, Qiao K, Ning S.
Int J Surg. 2024 Aug 1;110(8):4716-4726. doi: 10.1097/JS9.0000000000001582.
The Causal Effects between Mood Swings and Gastrointestinal Diseases: A Mendelian Randomization Study
Wang K, Wang S, Chen X.
Alpha Psychiatry. 2024 Aug 1;25(4):533-540. doi: 10.5152/alphapsychiatry.2024.241688.
Exploring the causal effect between lipid-modifying drugs and idiopathic pulmonary fibrosis: a drug-target Mendelian randomization study
Gexiang Cai, Jingjing Liu, Mengsi Cai, Lianyou Shao
Lipids Health Dis . 2024 Aug 1;23(1):237. doi: 10.1186/s12944-024-02218-6.

July

Evaluating the Causal Effect of Type 2 Diabetes on Alzheimer's Disease Using Large-Scale Genetic Data
Liu D, Baranova A, Zhang F.
J Prev Alzheimers Dis. 2024;11(5):1280-1282. doi: 10.14283/jpad.2024.148.
Genetic association and machine learning improves discovery and prediction of type 1 diabetes
McGrail C, Sears TJ, Kudtarkar P, Carter H, Gaulton K.
medRxiv 2024.07.31.24311310; doi: https://doi.org/10.1101/2024.07.31.24311310
Causal associations between 45 dietary intake habits and urolithiasis: insights from genetic studies
Yang L, Wang L, Liu Y, Bao E, Wang J, Xia L, Wang B, Zhu P.
Transl Androl Urol. 2024 Jul 31;13(7):1074-1084. doi: 10.21037/tau-24-79.
Mendelian randomization study of inflammatory bowel disease and type 1 diabetes
Zhu JY, Ma X, Liu MY, Ma LZ, Sun XR, Yan MY, Xue C, Sun C.
Endocrine. 2024 Jul 31. doi: 10.1007/s12020-024-03919-9.
Genetic support for the causal association between 91 circulating inflammatory proteins and atopic dermatitis: A two-sample Mendelian randomization trial
Du X, Shi H, Liu X, Wang Y, Du T, Wang P, Cheng L, Zhu J, Li F.
Skin Res Technol. 2024 Aug;30(8):e13872. doi: 10.1111/srt.13872.
Deciphering the Causality between Gut Microbiota Dysbiosis and Poisoning by Narcotics and Psychodysleptics: A Mendelian Randomization Analysis
Wang N, Su Z.
Curr Neuropharmacol. 2024 Jul 30. doi: 10.2174/1570159X22999240729092453.
The plasma lipids with different fatty acid chains are associated with the risk of hemorrhagic stroke: a Mendelian randomization study
Zhang X, Zhu X, Shi Q.
Front Neurol. 2024 Jul 30;15:1432878. doi: 10.3389/fneur.2024.1432878.
Machine learning-based proteogenomic data modeling identifies circulating plasma biomarkers for early detection of lung cancer
Johnson MA, Hou L, Huang BE, Saadatpour A, Torshizi AD.
medRxiv 2024.07.30.24311241; doi: https://doi.org/10.1101/2024.07.30.24311241
Association between metabolic dysfunction-associated steatotic liver disease and pulmonary function: a population-based and two-sample mendelian randomization study
Feng T, Li J, Wu L, He X, Ye J.
BMC Pulm Med. 2024 Jul 30;24(1):368. doi: 10.1186/s12890-024-03182-8.
Investigating the association between gut microbiome and aortic aneurysm diseases: a bidirectional two-sample Mendelian randomization analysis
Sun Y, Dong H, Sun C, Du D, Gao R, Voevoda M, Knyazev R, Wu N.
Front Cell Infect Microbiol. 2024 Jul 30;14:1406845. doi: 10.3389/fcimb.2024.1406845.
Association between periodontal disease and schizophrenia: a bidirectional two-sample Mendelian randomization study
Cao H, Wu H, Wang P, Zhang H, Wang S.
Sci Rep. 2024 Jul 29;14(1):17391. doi: 10.1038/s41598-024-65181-3.
Causal gene identification using mitochondria-associated genome-wide mendelian randomization in atrial fibrillation
Chen Y, Li B, Xu H, Wu L.
Front Pharmacol. 2024 Jul 29;15:1439816. doi: 10.3389/fphar.2024.1439816.
Investigation of the causal relationship between breast cancer and thyroid cancer: a set of two-sample bidirectional Mendelian randomization study
Xu JX, Chen YY, Qi LN, Peng YC.
Endocrine. 2024 Jul 29. doi: 10.1007/s12020-024-03976-0.
Assessing the genetic associations between plasma lipidomic profiles and psoriasis vulgaris
Zhang M, Yu S.
Arch Dermatol Res. 2024 Jul 29;316(8):494. doi: 10.1007/s00403-024-03217-4.
Associations between genetically predicted concentrations of plasma proteins and the risk of prostate cancer
Sun W, Li H, Shi W, Lv Q, Zhang W.
BMC Cancer. 2024 Jul 27;24(1):905. doi: 10.1186/s12885-024-12659-y.
Uncovering the Shared Genetic Components of Thyroid Disorders and Reproductive Health
Figuerêdo J, Krebs K, Pujol-Gualdo N, Haller T, Võsa U, Volke V; Estonian Biobank research team; Health Informatics research team; Laisk T, Mägi R.
Eur J Endocrinol. 2024 Jul 27:lvae094. doi: 10.1093/ejendo/lvae094.
Causal Effects of Oxidative Stress on Diabetes Mellitus and Microvascular Complications: Insights Integrating Genome-Wide Mendelian Randomization, DNA Methylation, and Proteome
Liu K, Chen Z, Liu L, Li T, Xing C, Han F, Mao H.
Antioxidants (Basel). 2024 Jul 26;13(8):903. doi: 10.3390/antiox13080903.
Integrating Mendelian randomization and single-cell RNA sequencing to identify therapeutic targets of baicalin for type 2 diabetes mellitus
Liang YC, Li L, Liang JL, Liu DL, Chu SF, Li HL.
Front Pharmacol. 2024 Jul 26;15:1403943. doi: 10.3389/fphar.2024.1403943.
Disentangling shared genetic etiologies for kidney function and cardiovascular diseases
Qiao J, Yao K, Yuan Y, Yang X, Zhou L, Long Y, Chen M, Xie W, Yang Y, Cao Y, Pauklin S, Xu J, Yang Y, Feng Y.
medRxiv 2024.07.26.24310191; doi: https://doi.org/10.1101/2024.07.26.24310191