Publikationslista

På den här sidan listar vi alla vetenskapliga publikationer som har använt data från FinnGen-studien.

2025

April

Protective effect of antidiabetic drugs against male infertility: evidence from Mendelian randomization

Li Y, Zhou T, Liu Z, Zhu X, Wu Q, Meng C, Deng Q.

Diabetol Metab Syndr. 2025 Apr 28;17(1):140. doi: 10.1186/s13098-025-01700-0.

Circulating linoleic acid and its interplay with gut microbiota during pregnancy for gestational diabetes mellitus

Qiu J, Hu P, Li F, Huang Y, Yang Y, Sun F, Wu P, Lai Y, Wang Y, He X, Dong Y, Zhang P, Zhang S, Wu N, Wang T, Yang S, Li S, Yuan J, Liu X, Liu G, Hu Y, Wu JHY, Chen D, Pan A, Pan XF.

BMC Med. 2025 Apr 28;23(1):245. doi: 10.1186/s12916-025-04061-7.

Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases

Yamamoto Y, Shirai Y, Sonehara K, Namba S, Ojima T, Yamamoto K, Edahiro R, Suzuki K, Kanai A; BioBank Japan Project; Oda Y, Suzuki Y, Morisaki T, Narita A, Takeda Y, Tamiya G, Yamamoto M, Matsuda K, Kumanogoh A, Yamauchi T, Kadowaki T, Okada Y.

Nat Commun. 2025 Apr 28;16(1):3765. doi: 10.1038/s41467-025-58149-y.

Association between lipid-lowering drug targets and the risk of cystic kidney disease: a drug-target Mendelian randomization analysis

Lian Z, Liang Z, Chen Q, Xie C, Kong Y.

Ren Fail. 2025 Dec;47(1):2491657. doi: 10.1080/0886022X.2025.2491657.

Causal role of immune cells in male infertility: a Mendelian randomization study

Liang Z, Hu C, Pang H, Sha Y, Lv J, Wu G, Du H, Hao L, Yao L, Liu F.

Transl Androl Urol. 2025 Apr 30;14(4):964-973. doi: 10.21037/tau-2024-657.

Metformin and Risks of Aortic Aneurysm and Aortic Dissection: A Mendelian Randomization Study

Wang L, Lin Z, Lin Y, Wu Q, Zhong G, Chen L.

Rev Cardiovasc Med. 2025 Apr 27;26(4):27734. doi: 10.31083/RCM27734.

Causal relationship between serum metalloproteinase 12 levels and aortic dissection and aortic aneurysm: a bidirectional Mendelian randomization study

Feng X, Chen S, Liu T, Huang H, Mariscalco G, Mestres CA, Taylor M, Nakamura K, Zheng B.

J Thorac Dis. 2025 Apr 30;17(4):2377-2385. doi: 10.21037/jtd-2025-377.

Genetic determinants of proteomic aging

Mörseburg A, Zhao Y, Kentistou KA, Perry JRB, Ong KK, Day FR.

NPJ Aging. 2025 Apr 26;11(1):30. doi: 10.1038/s41514-025-00205-4.

Investigating the causal relationship between immune cells and colorectal cancer risk using bidirectional and multivariable Mendelian randomization analysis

Zhou J, Liu Y.

J Recept Signal Transduct Res. 2025 Apr 26:1-10. doi: 10.1080/10799893.2025.2491068.

Tracing the pathways: how inflammatory cytokines and blood metabolites drive intervertebral disc degeneration

Liu Y, Lei F, Feng D, Luo J, Jin Q, Zhang H, Wang L.

Eur Spine J. 2025 Apr 26. doi: 10.1007/s00586-025-08850-9.

Causal roles of lipids and mediating proteins in diabetic retinopathy: insights from metabolomic and proteomic Mendelian randomization

Wang J, Su J, Liu D, Ma J.

Diabetol Metab Syndr. 2025 Apr 26;17(1):139. doi: 10.1186/s13098-025-01701-z.

Qiu J, Zhang Y.

J Mol Neurosci. 2025 Apr 26;75(2):58. doi: 10.1007/s12031-025-02347-2.

Exploring the potential causal association of gut microbiota on panic and conduct disorder: A two-sample Mendelian randomization approach

Fatoba A, Simpson C.

J Affect Disord. 2025 Apr 26:S0165-0327(25)00718-9. doi: 10.1016/j.jad.2025.04.143.

Serum metabolites and risk of sudden sensorineural hearing loss: A Mendelian randomization study

Yuan W, Liu Y, Liu C, Qiu Y.

Braz J Otorhinolaryngol. 2025 Apr 26;91(4):101596. doi: 10.1016/j.bjorl.2025.101596.

Mediators of the association between education and periodontitis: Mendelian randomization study

Chen YY, Wang LL, Mo SQ, Zhao DY, Fan YZ, Zhang RN, Zhu Z, Guo LL, Shen WQ.

BMC Oral Health. 2025 Apr 26;25(1):647. doi: 10.1186/s12903-025-06006-1.

Causal relationships between brain functional networks and tinnitus: A bidirectional 2-sample Mendelian randomization study

Zhong C, Zhang H, Wang L, Dong Y, Ji L, Guo Y.

Medicine (Baltimore). 2025 Apr 25;104(17):e42328. doi: 10.1097/MD.0000000000042328.

Mendelian Randomization with longitudinal exposure data: simulation study and real data application

Pott J, Palma M, Liu Y, Mack JA, Sovio U, Smith GCS, Barrett J, Burgess S.

medRxiv 2025.04.25.25326352; doi: https://doi.org/10.1101/2025.04.25.25326352

Bidirectional Mendelian randomization and potential mechanistic insights into the causal relationship between gut microbiota and malignant mesothelioma

Zhou Y, Zhu H, Zhao L, Zhao G, Sun J.

Medicine (Baltimore). 2025 Apr 25;104(17):e42245. doi: 10.1097/MD.0000000000042245.

Novel Genetic Risk Variants Associated with Oral Tongue Squamous Cell Carcinoma

Nikkilä R, Mäkitie A, Joensuu H, Markkanen S, Elenius K, Monni O, Palotie A, Saarentaus E; FinnGen; Salo T, Bizaki-Vallaskangas A.

Head Neck Pathol. 2025 Apr 25;19(1):45. doi: 10.1007/s12105-025-01784-0.

Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms

Wang F, Liu A, Yang Z, Vartiainen P, Jukarainen S, Koskela S, Oram R, Allen L, Ritari J, Partanen J; FinnGen; Perola M, Tuomi T, Ganna A.

Cell Genom. 2025 Apr 25:100854. doi: 10.1016/j.xgen.2025.100854.

Causal Association Between Sleep Deprivation and Glioblastoma Risk: Insights from Multi-Omics Analysis

Du R, Maierdan M, Yusufu A, Dong S, Cai X, Xu T, Sheng W, Maimaiti M.

J Mol Neurosci. 2025 Apr 24;75(2):56. doi: 10.1007/s12031-025-02354-3.

Multi-omics reveal the role of nociception-related genes TNXB, CTNND1 and CBL in depression

Wu Q, Lin D, Wang T, Lin W, Wang S, Lai L, Xie M, Wen X.

J Affect Disord. 2025 Aug 1;382:346-354. doi: 10.1016/j.jad.2025.04.067.

Integration of single-cell sequencing and mendelian randomization reveals novel causal pathways between monocytes and hepatocellular carcinoma

Yu J, Yu J, Kang Z, Peng Y.

Discov Oncol. 2025 Apr 24;16(1):604. doi: 10.1007/s12672-025-02357-x.

Association between sarcopenia and intervertebral disc degeneration: A bidirectional two-sample Mendelian randomization

Guo J, Ding Q, Sun L.

J Back Musculoskelet Rehabil. 2025 Apr 24:10538127251318926. doi: 10.1177/10538127251318926.

Evidence supporting the role of hypertension in the onset of migraine

Xiao G, Huang Z, Lan Q, Hu J, Shi H, Chen Y, Zhou C, Chenghua L, Zhou B.

J Transl Med. 2025 Apr 24;23(1):474. doi: 10.1186/s12967-025-06187-x.

Causal association between endocrine diseases and lymphoid malignancies explored through two-sample Mendelian randomization analysis

Zhao C, Zhang Y, Qian L, Guo Q, Zhu N.

Sci Rep. 2025 Apr 24;15(1):14231. doi: 10.1038/s41598-025-99010-y.

Nonsteroidal anti-inflammatory drugs, blood metabolites, and kidney stones: a comprehensive Mendelian randomization study

Yu H, Zeng F, Wu J, Chen H, Huang F, Zhu Z.

Urolithiasis. 2025 Apr 24;53(1):77. doi: 10.1007/s00240-025-01749-6.

Multi-ancestry sequencing-based genome-wide association study of C-reactive protein in 513,273 genomes

Li H, Zhao J, Dai J, You D, Zhao Y, Christiani DC, Chen F, Shen S.

Nat Commun. 2025 Apr 24;16(1):3892. doi: 10.1038/s41467-025-59155-w.

Elucidating Cellular Senescence-related Genes in Benign Prostatic Hyperplasia through Mendelian Randomization and Single-cell RNA Sequencing

Wang Y, Zhou L, Liu J, Zhou Q, Xiong W, Wang L.

J Gerontol A Biol Sci Med Sci. 2025 Apr 23:glaf073. doi: 10.1093/gerona/glaf073.

Integrated multi-omics insight into the molecular networks of oxidative stress in triggering multiple sclerosis

Xu Y, Zhang X, Zhang Y, Ma H, Zhou Z, Qin H, Liu H, Han X.

Neurobiol Dis. 2025 Jun 15;210:106929. doi: 10.1016/j.nbd.2025.106929.

The causal relationship between gastroesophageal reflux disease and constipation: a study utilizing bidirectional mendelian randomization combined with meta-analysis

Xingxing Wei, Xiangming Che

Researchsquare, 23 April 2024, doi: 10.21203/rs.3.rs-4286883/v1

Causal relationship between atherosclerosis and inflammatory bowel disease risk: a two-sample Mendelian randomization study

Guo W, Peng N, Du S.

Thromb J. 2025 Apr 23;23(1):39. doi: 10.1186/s12959-025-00722-y.

Potential association between allergic disease and risk of Alzheimer’s disease: insight from genetic analysis

Jin T, Huang W, Cheng Y, Cao Z, Guo S, Li C.

BMC Neurol. 2025 Apr 23;25(1):173. doi: 10.1186/s12883-025-04192-7.

Uncovering therapeutic targets for Pre-eclampsia and pregnancy hypertension via multi-tissue data integration

Yao H, Chen J, Wang Y, Li Y, Tang P, Liang M, Jiang Q.

BMC Pregnancy Childbirth. 2025 Apr 23;25(1):479. doi: 10.1186/s12884-025-07608-x.

DNA methylation and 28 year incidence of two neuropathy phenotypes in type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications cohort study

Zhou J, Mychaleckyj JC, Onengut-Gumuscu S, Orchard TJ, Costacou T, Miller RG.

Diabetologia. 2025 Jul;68(7):1423-1439. doi: 10.1007/s00125-025-06427-1.

Multiomic insight into the involvement of cell aging related genes in the pathogenesis of endometriosis

Chen L, Yi Y, Nie J.

Sci Rep. 2025 Apr 23;15(1):14103. doi: 10.1038/s41598-025-96711-2.

Bidirectional Mendelian randomization reveals associations between telomere length and autoimmune diseases

Jiang Q, Yu C, Zhu S, Liu Y, Ye M.

Trials. 2025 Apr 23;26(1):137. doi: 10.1186/s13063-025-08831-9.

Combining GWAS Summary Data and Proteomics Identified Potential Drug Targets in Dementia

Zhao Y, Fei L, Duan Y.

Mol Neurobiol. 2025 Apr 23. doi: 10.1007/s12035-025-04967-6.

Sleep deprivation impacts the immunological milieu of epididymis leading to low sperm quality in rats

Li Z, Gong S, Yu Z, Luo Y, Zhao Y, Xue E, Lu H, Xiang D, Sun F.

Commun Biol. 2025 Apr 22;8(1):644. doi: 10.1038/s42003-025-08091-y.

Association between age at diabetes diagnosis and the development and progression of diabetic retinopathy

Li H, Wang B, Liu C.

Sci Rep. 2025 Apr 22;15(1):13827. doi: 10.1038/s41598-025-98840-0.

Genome-Wide Assessment of Pleiotropy Across >1000 Traits from Global Biobanks

Levin MG, Koyama S, Woerner J, Zhang DY, Rodriguez A, Nandi T, Truong B, Abramowitz SA, Gupta H, Kamineni H, Hornsby W, Li Z, Cohron T, Huffman JE, Ellinor P, Kim D, Liao KP, Madduri RK, Voight BF, Verma A, Damrauer SM, Natarajan P.

medRxiv [Preprint]. 2025 Apr 22:2025.04.18.25326074. doi: 10.1101/2025.04.18.25326074.

Exploring the effect of SGLT2 inhibitors on the risk of primary open-angle glaucoma using Mendelian randomization analysis

Guo Y, Zhao J, Hou S, Chen Z.

Sci Rep. 2025 Apr 22;15(1):13946. doi: 10.1038/s41598-025-98997-8.

Elevated VRK2 expression promotes the onset and progression of bronchiectasis

Zheng S, Huang Y, Hong K, Tang J, Wu X, Qing C, Jiang Y, Lu W, Bao C, Luo J & Kong J.

The Egyptian Journal of Bronchology (2025) 19:36 https://doi.org/10.1186/s43168-025-00390-6

Exploring the comorbidity association and biological mechanisms of chronic rhinosinusitis and chronic obstructive pulmonary disease

Liu S, Yang J, Lin Y, Zhang L, Luo W.

Sci Rep. 2025 Apr 22;15(1):13855. doi: 10.1038/s41598-025-98175-w.

Identification of mitochondrial-related causal genes for major depression disorder via integrating multi-omics

Li H, Liu Q, Shan Q, Xu H, Wang J, Liu L, Wang Y.