Below you will find all the published and preprint scientific papers using FinnGen data.

2023

December

No Causal Association Between Cholelithiasis and COVID-19: A Bidirectional Mendelian Randomization Study
Chang-Lei Li, Ao Sun, Guan-Ming Shao, Jing-Yu Cao, Zu-Sen Wang
Researchsquare, 06 December 2023, doi:10.21203/rs.3.rs-3692879/v1
Genetic effect of metformin use on risk of cancers: evidence from Mendelian randomization analysis
Chen Y, Bai B, Ye S, Gao X, Zheng X, Ying K, Pan H, Xie B
Diabetol Metab Syndr. 2023 Dec 6;15(1):252. doi: 10.1186/s13098-023-01218-3.
Cortical structural changes of morphometric similarity network in early-onset schizophrenia correlate with specific transcriptional expression patterns
Yao G, Zou T, Luo J, Hu S, Yang L, Li J, Li X, Zhang Y, Feng K, Xu Y, Liu P.
BMC Med. 2023 Dec 5;21(1):479. doi: 10.1186/s12916-023-03201-1.
Sexual behavior and cardiovascular diseases: univariable and multivariable Mendelian randomization
Zhu K, Lin Z, Luo Q, Jiang Z, He R, Wu H, Yu J, Liu X, Sheng J, Zhu H, Huang H
Front Cardiovasc Med. 2023 Dec 5;10:1250404. doi: 10.3389/fcvm.2023.1250404
Association of autoimmune diseases with the occurrence and 28-day mortality of sepsis: an observational and Mendelian randomization study
Li H, Pan X, Zhang S, Shen X, Li W, Shang W, Wen Z, Huang S, Chen L, Zhang X, Chen D, Liu J
Crit Care. 2023 Dec 5;27(1):476. doi: 10.1186/s13054-023-04763-5.
Association between viral infections and glioma risk: a two-sample bidirectional Mendelian randomization analysis
Zhong S, Yang W, Zhang Z, Xie Y, Pan L, Ren J, Ren F, Li Y, Xie H, Chen H, Deng D, Lu J, Li H, Wu B, Chen Y, Peng F, Puduvalli VK, Sai K, Li Y, Cheng Y, Mou Y.
BMC Med. 2023 Dec 5;21(1):487. doi: 10.1186/s12916-023-03142-9.
Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease
Yang F, Xu F, Zhang H, Gill D, Larsson SC, Li X, Cui H, Yuan S
BMC Med. 2023 Dec 5;21(1):485. doi: 10.1186/s12916-023-03197-8
The Association Between SHBG and Osteoporosis: A NHANES Cross-Sectional Study and A Bidirectional Mendelian Randomization
Huang W, Xiao Y, Zhang L, Liu H
Calcif Tissue Int. 2023 Dec 5. doi: 10.1007/s00223-023-01166-0
The Causal Association between Alcohol, Smoking, Coffee Consumption, and the Risk of Arthritis: A Meta-Analysis of Mendelian Randomization Studies
Wang J, Zhang B, Peng L, Wang J, Xu K, Xu P.
Nutrients. 2023 Dec 4;15(23):5009. doi: 10.3390/nu15235009.
Circulating Biomarkers and Risk of Hypertension: A Two-Sample Mendelian Randomisation Study
Li J, Yao YX, Yao PS
Heart Lung Circ. 2023 Dec 1:S1443-9506(23)04312-3. doi: 10.1016/j.hlc.2023.09.003
Association between gut microbiota and NAFLD/NASH: a bidirectional two-sample Mendelian randomization study
Zhai Q, Wu H, Zheng S, Zhong T, Du C, Yuan J, Peng J, Cai C, Li J
Front Cell Infect Microbiol. 2023 Dec 1;13:1294826. doi: 10.3389/fcimb.2023.1294826
Causal relationships between coffee intake, apolipoprotein B and gastric, colorectal, and esophageal cancers: univariable and multivariable Mendelian randomization
Liu X, Yu H, Yan G, Xu B, Sun M, Feng M
Eur J Nutr. 2023 Dec 1. doi: 10.1007/s00394-023-03281-y

November

NTHL1 is a recessive cancer susceptibility gene
Nurmi AK, Pelttari LM, Kiiski JI, Khan S, Nurmikolu M, Suvanto M, Aho N, Tasmuth T, Kalso E, Schleutker J, Kallioniemi A, Heikkilä P; FinnGen; Aittomäki K, Blomqvist C, Nevanlinna H
Sci Rep. 2023 Nov 30;13(1):21127. doi: 10.1038/s41598-023-47441-w
Causal effects of gut microbiome on endometriosis: a two-sample mendelian randomization study
Liu Z, Chen P, Luo L, Liu Q, Shi H, Yang X
BMC Womens Health. 2023 Nov 30;23(1):637. doi: 10.1186/s12905-023-02742-0
The causal association between smoking, alcohol consumption and risk of upper urinary calculi: insights from a Mendelian randomization study
Wang L, Yin S, Li KP, Bao EH, Wang JH, Zhu PY
Front Genet. 2023 Nov 30;14:1268720. doi: 10.3389/fgene.2023.1268720
Identification of heel bone mineral density as a risk factor of Alzheimer's disease by analyzing large-scale genome-wide association studies datasets
Gao F, Pan R, Fan T, Liu L, Pan H
Front Cell Dev Biol. 2023 Nov 30;11:1247067. doi: 10.3389/fcell.2023.1247067
East Asian-specific and cross-ancestry genome-wide meta-analyses provide mechanistic insights into peptic ulcer disease
He Y, Koido M, Sutoh Y, Shi M, Otsuka-Yamasaki Y, Munter HM; BioBank Japan; Morisaki T, Nagai A, Murakami Y, Tanikawa C, Hachiya T, Matsuda K, Shimizu A, Kamatani Y.
Nat Genet. 2023 Dec;55(12):2129-2138. doi: 10.1038/s41588-023-01569-7.
Genetically Determined Metabolites in Graves Disease: Insight From a Mendelian Randomization Study
Tan Y, Yin J, Cao J, Xie B, Zhang F, Xiong W
J Endocr Soc. 2023 Nov 30;8(1):bvad149. doi: 10.1210/jendso/bvad149
Evaluation of causal associations between interleukin-18 levels and immune-mediated inflammatory diseases: a Mendelian randomization study
Wu J, Zhang X, Wu D, Jin O, Gu J.
BMC Med Genomics. 2023 Nov 29;16(1):306. doi: 10.1186/s12920-023-01744-z.
Causal associations of mental health disorders with aortic and peripheral vascular disease: a bi-directional two- sample mendelian randomization study
Minyong Peng, Chengli Nie, Chao Li, Rui Yang, Pan Ran, Qian Peng, Jie Hu
Researchsquare, 29 November 2023, doi: 10.21203/rs.3.rs-3543406/v1
Causal association between dietary factors and esophageal diseases: A Mendelian randomization study
Zou M, Liang Q, Zhang W, Zhu Y, Xu Y
PLoS One. 2023 Nov 29;18(11):e0292113. doi: 10.1371/journal.pone.0292113
Mitochondrial DNA copy number is associated with Crohn's disease: a comprehensive Mendelian randomization analysis
Cai X, Li X, Liang C, Zhang M, Xu Y, Dong Z, Weng Y, Yu W.
Sci Rep. 2023 Nov 29;13(1):21016. doi: 10.1038/s41598-023-48175-5.
Mendelian randomization reveals no correlations between herpesvirus infection and idiopathic pulmonary fibrosis
Yan H, Zhu C, Jin X, Feng G
PLoS One. 2023 Nov 28;18(11):e0295082. doi: 10.1371/journal.pone.0295082
The value of genetic data from 665,460 individuals in managing iron deficiency anaemia and suitability to donate blood
Toivonen J, Allara E; FinnGen; Castrén J, di Angelantonio E, Arvas M
Vox Sang. 2023 Nov 28. doi: 10.1111/vox.13564
Promising therapeutic targets for ischemic stroke identified from plasma and cerebrospinal fluid proteomes: A multicenter mendelian randomization study
Zou X, Wang L, Wang S, Zhang Y, Ma J, Chen L, Li Y, Yao TX, Zhou H, Wu L, Tang Q, Ma S, Zhang X, Tang R, Yi Y, Liu R, Zeng Y, Zhang L
Int J Surg. 2023 Nov 28. doi: 10.1097/JS9.0000000000000922
Appraising the causal relationship between thyroid function and rheumatoid arthritis: a two-sample bidirectional Mendelian randomization study
Gu P, Pu B, Ma Y, Yue D, Xin Q, Li H, Liu T, Zheng X, Ouyang C
Front Immunol. 2023 Nov 28;14:1238757. doi: 10.3389/fimmu.2023.1238757.
Patients with periodontitis might increase the risk of urologic cancers: a bidirectional two-sample Mendelian randomization study
Li B, Lin Y, Yang Y, Wang Z, Shi R, Zheng T, Liao B, Liao G, Huang J
Int Urol Nephrol. 2023 Nov 28. doi: 10.1007/s11255-023-03858-w
Causal associations between inflammatory bowel disease and anxiety: A bidirectional Mendelian randomization study
He Y, Chen CL, He J, Liu SD
World J Gastroenterol. 2023 Nov 28;29(44):5872-5881. doi: 10.3748/wjg.v29.i44.5872
Exploring the causal relationship between periodontitis and gut microbiome: Unveiling the oral-gut and gut-oral axes through bidirectional Mendelian randomization
Chen H, Peng L, Wang Z, He Y, Zhang X
J Clin Periodontol. 2023 Nov 28. doi: 10.1111/jcpe.13906
Genetically predicted plasma levels of amino acids and metabolic dysfunction-associated fatty liver disease risk: a Mendelian randomization study
Zhao J, Zeng J, Zhu C, Li X, Liu D, Zhang J, Li F, Targher G, Fan JG.
BMC Med. 2023 Nov 28;21(1):469. doi: 10.1186/s12916-023-03185-y.
Body composition and risk of gestational diabetes mellitus: A univariable and multivariable Mendelian randomization study
Gao Y, Zhou M, Xu X, Ma JY, Qin MF
J Diabetes Investig. 2023 Nov 27. doi: 10.1111/jdi.14115
Genetically Proxied Therapeutic Effect of Metformin Use, Blood Pressure, and Hypertension's Risk: a Drug Target-Based Mendelian Randomization Study
Jiang J, Hu D, Zhang Q, Lin Z; μ-Biomedical Data Investigation Group (Mu-BioDig).
J Cardiovasc Transl Res. 2023 Nov 27. doi: 10.1007/s12265-023-10460-z.
Effect of Glucosamine on Intraocular Pressure and Risk of Developing Glaucoma
Lehrer S, Morello T, Karrasch C, Rheinstein PH, Danias J.
J Glaucoma. 2023 Nov 24. doi: 10.1097/IJG.0000000000002340.
Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation
Mälarstig A, Grassmann F, Dahl L, Dimitriou M, McLeod D, Gabrielson M, Smith-Byrne K, Thomas CE, Huang TH, Forsberg SKG, Eriksson P, Ulfstedt M, Johansson M, Sokolov AV, Schiöth HB, Hall P, Schwenk JM, Czene K, Hedman ÅK.
Nat Commun. 2023 Nov 24;14(1):7680. doi: 10.1038/s41467-023-43485-8.
Causal link between gut microbiota and four types of pancreatitis: a genetic association and bidirectional Mendelian randomization study
Wang K, Qin X, Ran T, Pan Y, Hong Y, Wang J, Zhang X, Shen X, Liu C, Lu X, Chen Y, Bai Y, Zhang Y, Zhou C, Zou D
Front Microbiol. 2023 Nov 23;14:1290202. doi: 10.3389/fmicb.2023.1290202
Causal relationship between gut microbiota and immune thrombocytopenia: a Mendelian randomization study of two samples
Guo D, Chen Q, Wang G, Li C; FinnGen consortium
Front Microbiol. 2023 Nov 23;14:1190866. doi: 10.3389/fmicb.2023.1190866
Genetically predicted causal associations between periodontitis and psychiatric disorders
Tong S, Lyu Y, Huang W, Zeng R, Jiang R, Lian Q, Leung FW, Sha W, Chen H
BMJ Ment Health. 2023 Nov 22;26(1):e300864. doi: 10.1136/bmjment-2023-300864
Narcolepsy and psychiatric disorders: A bidirectional Mendelian randomization study
Li B, Gao Z, He Y, Tian Y, Shen Y, Yu G, Geng X, Kou C
J Psychiatr Res. 2023 Nov 21;169:42-48. doi: 10.1016/j.jpsychires.2023.11.034
Can periodontitis lead to adverse pregnancy outcomes: A Mendelian Randomization study
Tianxing Yan, Yiping Wei, Wenjie Hu
Researchsquare, 21 November 2023, doi:10.21203/rs.3.rs-3628808/v1
New insight into the causal relationship between Graves' disease liability and drug eruption: a Mendelian randomization study.
Wu D, Liu B, Xian W, Yang Y, Li J, Hong S, Li Y, Xiao H
Front Immunol. 2023 Nov 21;14:1267814. doi: 10.3389/fimmu.2023.1267814
Gut microbiota and risk of polycystic ovary syndrome: Insights from Mendelian randomization
Li JW, Chen YZ, Zhang Y, Zeng LH, Li KW, Xie BZ, Luo SP, Gao J
Heliyon. 2023 Nov 21;9(12):e22155. doi: 10.1016/j.heliyon.2023.e22155
The causal relationship between physical activity, sedentary time and idiopathic pulmonary fibrosis risk: a Mendelian randomization study
Lei W, Yang M, Yuan Z, Feng R, Kuang X, Liu Z, Deng Z, Hu X, Tai W
Respir Res. 2023 Nov 20;24(1):291. doi: 10.1186/s12931-023-02610-3
Genetics of sleep medication purchases suggests causality from sleep problems to psychiatric traits
Broberg M, Helaakoski V, Kiiskinen T, Paunio T, Jones SE, Mars N, Lane JM; FinnGen; Saxena R, Ollila HM
Sleep. 2023 Nov 20:zsad279. doi: 10.1093/sleep/zsad279
The causal role of immune cells in rheumatoid arthritis: a Mendelian randomization study
wei yang, Zhenhua Li, Xiuzhen Han, Miao Cui, Mingze Han, Jianan Yu, Yi Qu, Haorui Shi
Researchsquare, 20 November 2023, doi:10.21203/rs.3.rs-3610819/v1
Causal association of calcific aortic valve stenosis and atrial fibrillation: a Mendelian randomization study
Chai C, Li S, Chen L, Song X
Sci Rep. 2023 Nov 20;13(1):20284. doi: 10.1038/s41598-023-47770-w
Roles of human gut microbiota in liver cirrhosis risk: a two-sample mendelian randomization study
Li O, Xu H, Kim D, Yang F, Bao Z
J Nutr. 2023 Nov 18:S0022-3166(23)72727-2. doi: 10.1016/j.tjnut.2023.11.011
Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture
Hao X, Shao Z, Zhang N, Jiang M, Cao X, Li S, Guan Y, Wang C
Nat Commun. 2023 Nov 18;14(1):7498. doi: 10.1038/s41467-023-43400-1
Gastroesophageal Reflux Disease and Rhinosinusitis: A Bidirectional Mendelian Randomization Study
Chen TY, Lv MH, Lai RJ, Hu YQ, Ye ZK, Lv QL, Chen BY, Wu JT, Hong H, Li S
Int Arch Allergy Immunol. 2023 Nov 17:1-8. doi: 10.1159/000534676
Causal Effect of Relative Carbohydrate Intake on Hypertension through Psychological Well-Being and Adiposity: A Mendelian Randomization Study
Ye C, Kong L, Wang Y, Dou C, Xu M, Zheng J, Zheng R, Xu Y, Li M, Zhao Z, Lu J, Chen Y, Wang W, Bi Y, Wang T, Ning G
Nutrients. 2023 Nov 17;15(22):4817. doi: 10.3390/nu15224817
Intervertebral Disk Degeneration and Bone Mineral Density: A Bidirectional Mendelian Randomization Study
Zhao J, Wang J, Xu H, Hu W, Shi F, Fan Z, Zhou C, Mu H
Calcif Tissue Int. 2023 Nov 17. doi: 10.1007/s00223-023-01165-1