Below you will find all the published and preprint scientific papers using FinnGen data.

2023

November

Exploring the causal relationship between inflammatory cytokines and inflammatory arthritis: A Mendelian randomization study
Pan S, Wu S, Wei Y, Liu J, Zhou C, Chen T, Zhu J, Tan W, Huang C, Feng S, Zhang B, Wei W, Zhan X, Liu C
Cytokine. 2023 Nov 16;173:156446. doi: 10.1016/j.cyto.2023.156446.
Serum uric acid and risk of diabetic neuropathy: a genetic correlation and mendelian randomization study
Zhang Y, Tang Z, Tong L, Wang Y, Li L
Front Endocrinol (Lausanne). 2023 Nov 15;14:1277984. doi: 10.3389/fendo.2023.1277984
The role of admixture in the rare variant contribution to inflammatory bowel disease
Astore C, Sharma S, Nagpal S; NIDDK IBD Genetics Consortium; Cutler DJ, Rioux JD, Cho JH, McGovern DPB, Brant SR, Kugathasan S, Jordan IK, Gibson G
Genome Med. 2023 Nov 15;15(1):97. doi: 10.1186/s13073-023-01244-w
Beverage consumption and diabetic retinopathy: a two-sample Mendelian randomization study
Xufang Sun, Suyun Rao, Ziqing Zhou, Ruohong Wang, Yuhe Tan
Researchsquare, 15 November 2023, doi: 10.21203/rs.3.rs-3505911/v1
The role of NSAID in mediating the effect of genetically predicted major depressive disorder on osteomyelitis: A Mendelian randomization study
Chen B, Pu B, Li S, Gong Y, Dong H
J Affect Disord. 2023 Nov 15;341:62-66. doi: 10.1016/j.jad.2023.08.121
Assessing the journey of calcium supplementation: A mendelian randomization study on the causal link between calcium levels and sleep disorders
Ma L, Huo Y, Peng T, Liu Z, Ye J, Chen L, Wu D, Du W, Chen J.
Clin Nutr ESPEN. 2024 Feb;59:1-8. doi: 10.1016/j.clnesp.2023.10.039.
Predicting the causal relationship between polyunsaturated fatty acids and cerebral aneurysm risk from a Mendelian randomization study
Yu W, Mei Y, Li C, Lu Z, Chen X, Yu H, Chen X, Huang Q, Li Z, Xiao D, Zhou L, Wang Z
medRxiv 2023.11.15.23298570; doi: https://doi.org/10.1101/2023.11.15.23298570
Association of coffee and caffeine consumption with risk and prognosis of endometrial cancer and its subgroups: a Mendelian randomization
Chen Z, Liu C, Wu J, Kong F
Front Nutr. 2023 Nov 14;10:1291355. doi: 10.3389/fnut.2023.1291355
Exploring Causal Cytokines and Potential Regulatory Genes in Bronchiectasis: Findings from Mendelian randomization
Wan-Zhe Liao, Hao-Bin Zhou, Zi-Kai Lin, Zhi-Yi Zhou, Xu-Guang Guo
Researchsquare, 13 November 2023, doi:10.21203/rs.3.rs-3588224/v1
Rheumatoid arthritis increases the risk of malignant neoplasm of bone and articular cartilage: a two-sample bidirectional mendelian randomization study
Yang M, Su Y, Xu K, Xie J, Wen P, Liu L, Yang Z, Xu P
Arthritis Res Ther. 2023 Nov 13;25(1):219. doi: 10.1186/s13075-023-03205-5
Brain-Wide Mendelian Randomization Study of Anxiety Disorders and Symptoms
Zanoaga MD, Friligkou E, He J, Pathak GA, Koller D, Cabrera-Mendoza B, Stein MB, Polimanti R
Biol Psychiatry. 2023 Nov 13:S0006-3223(23)01718-3. doi: 10.1016/j.biopsych.2023.11.006
Genome-wide association study analysis of disease severity in Acne reveals novel biological insights
Du Z, Iyyanki T, Lessard S, Chao M, FinnGen, Asbrand C, Nassar D, Klinger K, de Rinaldis E, Khader S, Chatelain C
medRxiv 2023.11.13.23298473; doi: https://doi.org/10.1101/2023.11.13.23298473
Does gestational diabetes mellitus increase the risk of cardiovascular disease? A Mendelian randomization study
Liang W, Sun FF
J Endocrinol Invest. 2023 Nov 12. doi: 10.1007/s40618-023-02233-x
Unraveling shared risk factors for diabetic foot ulcer: a comprehensive Mendelian randomization analysis
Yin K, Qiao T, Zhang Y, Liu J, Wang Y, Qi F, Deng J, Zhao C, Xu Y, Cao Y
BMJ Open Diabetes Res Care. 2023 Nov;11(6):e003523. doi: 10.1136/bmjdrc-2023-003523
Proteome-wide Mendelian randomization highlights AIF1 and HLA-DQA2 as targets for primary sclerosing cholangitis
Chen L, Zhao Y, Li M, Lv G
Hepatol Int. 2023 Nov 11. doi: 10.1007/s12072-023-10608-8
Protective effect of uridine on atrial fibrillation: a Mendelian randomisation study
Xu X, Zhang X, Cheng S, Li Q, Chen C, Ouyang M
Sci Rep. 2023 Nov 10;13(1):19639. doi: 10.1038/s41598-023-47025-8
Causal effect between gut microbiota and pancreatic cancer: a two-sample Mendelian randomization study
Jiang Z, Mou Y, Wang H, Li L, Jin T, Wang H, Liu M, Jin W
BMC Cancer. 2023 Nov 10;23(1):1091. doi: 10.1186/s12885-023-11493-y
Assessment of the relationship between thyroid function and panic disorder: A mendelian randomization study
Sijie Yu, Chongkai Shen, Junpeng Zhu
Researchsquare, 10 November 2023, doi: 10.21203/rs.3.rs-3577312/v1
Causal association between tea intake and acute cerebrovascular events: a multivariate Mendelian randomized study in European populations
Deng X, Zhu J, Liang J, Chang W, Lv X, Lai R, Gong L, Cai Y, Liu S
J Nutr. 2023 Nov 9:S0022-3166(23)72714-4. doi: 10.1016/j.tjnut.2023.10.027
The genetics of falling susceptibility and identification of causal risk factors
Smith MC, O'Loughlin J, Karageorgiou V, Casanova F, Williams GKR, Hilton M, Tyrrell
Sci Rep. 2023 Nov 9;13(1):19493. doi: 10.1038/s41598-023-44566-w
No causal effect of genetically determined circulating homocysteine levels on psoriasis in the European population: evidence from a Mendelian randomization study
Chen C, Liu S, Liu J, Zheng Z, Zheng Y, Lin Z, Liu Y
Front Immunol. 2023 Nov 8;14:1288632. doi: 10.3389/fimmu.2023.1288632
Roles of gut microbiota in atrial fibrillation: insights from Mendelian randomization analysis and genetic data from over 430,000 cohort study participants
Dai H, Hou T, Wang Q, Hou Y, Zhu Z, Zhu Y, Zhao Z, Li M, Lin H, Wang S, Zheng R, Xu Y, Lu J, Wang T, Ning G, Wang W, Zheng J, Bi Y, Xu M
Cardiovasc Diabetol. 2023 Nov 8;22(1):306. doi: 10.1186/s12933-023-02045-6.
Milo2.0 unlocks population genetic analyses of cell state abundance using a count-based mixed model
Alice K, Marioni JC, Morgan MD
bioRxiv 2023.11.08.566176; doi: https://doi.org/10.1101/2023.11.08.566176
Causal relationship between gut microbiota and myasthenia gravis: a bidirectional mendelian randomization study
Su T, Yin X, Ren J, Lang Y, Zhang W, Cui L
Cell Biosci. 2023 Nov 7;13(1):204. doi: 10.1186/s13578-023-01163-8
Reassessment of casual association between body mass index and site-specific solid cancers: A comprehensive Mendelian randomization study
Jianxiong Lai, Yuanhui Xu, Jian Li
Researchsquare, 07 November 2023, doi:10.21203/rs.3.rs-3552788/v1
Effects of gut microbiota on prostatic cancer: a two-sample Mendelian randomization study
Xie Q, Hu B
Front Microbiol. 2023 Nov 6;14:1250369. doi: 10.3389/fmicb.2023.1250369
Causal associations between modifiable risk factors and intervertebral disc degeneration
Guo W, Li BL, Zhao JY, Li XM, Wang LF
Spine J. 2023 Nov 6:S1529-9430(23)03487-3. doi: 10.1016/j.spinee.2023.10.021
Circadian Rhythm and the Risk of Cardiovascular Diseases: Genetic Evidence
Yan L, Chen J, Li F, Chen Y, Mei Z, Chen L
Aging Dis. 2023 Nov 5. doi: 10.14336/AD.2023.1018
Therapeutic targets for endometriosis: genome-wide Mendelian randomization and colocalization analyses
Zeng P, Lu L, Zhang H, Li Y, Tan S, Yu T, Zhou H
Gene. 2023 Nov 4:147970. doi: 10.1016/j.gene.2023.147970
Impact of blood pressure and antihypertensive drug classes on intracranial aneurysm: a Mendelian randomization study
Zeng Y, Guo R, Cao S, Yang H
J Stroke Cerebrovasc Dis. 2023 Nov;32(11):107355. doi: 10.1016/j.jstrokecerebrovasdis.2023.107355
Causal Relationship Study Between Basal Metabolic Rate and the Risk of Dental Caries: Evidence from Genome-Wide Association Analysis
Chengxi Li, Xue Wang
Researchsquare, 02 November 2023, doi:10.21203/rs.3.rs-3512528/v1
Causal relationship between sleep apnea and non-alcoholic fatty liver disease: A Mendelian randomization study
Zhang Z, Li M, Ji G, Zhang L
Eur J Clin Invest. 2023 Nov 2:e14116. doi: 10.1111/eci.14116
Investigation on the association between serum lipid levels and periodontitis: a bidirectional Mendelian randomization analysis
Chen Z, Song J, Tang L
BMC Oral Health. 2023 Nov 2;23(1):827. doi: 10.1186/s12903-023-03575-x
Causal effect of gallstone disease on the risk of coronary heart disease or acute myocardial infarction: a Mendelian randomization study
Fu Q, Shen T, Yu Q, Jiang L, Yang R
Sci Rep. 2023 Nov 1;13(1):18807. doi: 10.1038/s41598-023-46117-9
Mendelian Randomization Analysis of Genetic Proxies of Thiazide Diuretics and the Reduction of Kidney Stone Risk
Triozzi JL, Hsi RS, Wang G, Akwo EA, Wheless L, Chen HC, Tao R, Ikizler TA, Robinson-Cohen C, Hung AM; VA Million Veteran Program
JAMA Netw Open. 2023 Nov 1;6(11):e2343290. doi: 10.1001/jamanetworkopen.2023.43290
Association of APOE Haplotypes With Common Age-Related Ocular Diseases in 412,171 Individuals
Liuska PJ, Rämö JT, Lemmelä S, Kaarniranta K, Uusitalo H, Lahtela E, Daly MJ, Harju M, Palotie A, Turunen JA; FinnGen Study†
Invest Ophthalmol Vis Sci. 2023 Nov 1;64(14):33. doi: 10.1167/iovs.64.14.33
Causal relationships between circulating inflammatory cytokines and diffuse large B cell lymphoma: a bidirectional Mendelian randomization study
Yu J, Fu L, Zhang Z, Ding L, Hong L, Gao F, Jin J, Feng W, Fu J, Hong P, Xu C.
Clin Exp Med. 2023 Nov 1. doi: 10.1007/s10238-023-01221-y
Correlation between diabetic retinopathy and diabetic nephropathy: a two-sample Mendelian randomization study
Fang J, Luo C, Zhang D, He Q, Liu L
Front Endocrinol (Lausanne). 2023 Nov 1;14:1265711. doi: 10.3389/fendo.2023.1265711

October

Genetic causal relationship between gut microbiome and psoriatic arthritis: a bidirectional two-sample Mendelian randomization study
Qian X, Fu Z, Diao C, Zhang W, Tao W, Hu J, Zhang S, Zhao D
Front Microbiol. 2023 Oct 31;14:1265786. doi: 10.3389/fmicb.2023.1265786
Association between Liver MRI Proton Density Fat Fraction and Liver Disease Risk
Xia T, Du M, Li H, Wang Y, Zha J, Wu T, Ju S
Radiology. 2023 Oct;309(1):e231007. doi: 10.1148/radiol.231007
No evident causal association between Helicobacter pylori infection and colorectal cancer: a bidirectional mendelian randomization study
Luo F, Zhou P, Ran X, Gu M, Zhou S
Sci Rep. 2023 Oct 29;13(1):18544. doi: 10.1038/s41598-023-45545-x
Increased risk of dementia differs across cardiovascular diseases and types of dementia - Data from a nationwide study
Kauko A, Engler D, Niiranen T, Ortega-Alonso A, Schnabel RB
J Intern Med. 2023 Oct 29. doi: 10.1111/joim.13733
A bidirectional Mendelian randomisation study to evaluate the relationship between body constitution and hearing loss
He Y, Karhunen V, Pulakka A, Kantomaa M, Sebert S
Sci Rep. 2023 Oct 27;13(1):18434. doi: 10.1038/s41598-023-44735-x
A Mendelian randomization study revealed a causal link between napping and deep vein thrombosis (DVT)
Yan D, Liu G, Yin Y, Zhang Q, Shi D, Zhang J, Li Y
Sleep Breath. 2023 Oct 26. doi: 10.1007/s11325-023-02940-y
Causality Investigation between Gut Microbiota, Derived Metabolites, and Obstructive Sleep Apnea: A Bidirectional Mendelian Randomization Study
Yan W, Jiang M, Hu W, Zhan X, Liu Y, Zhou J, Ji J, Wang S, Tai J
Nutrients. 2023 Oct 26;15(21):4544. doi: 10.3390/nu15214544
Risk factors for severe respiratory syncytial virus infection during the first year of life: development and validation of a clinical prediction model
Vartiainen P, Jukarainen S, Rhedin SA, Prinz A, Hartonen T, Vabalas A, Viippola E, Rodosthenous RS, Koskelainen S, Liu A, Lundholm C, Smew AI, Osvald EC, Helle E, Perola M, Almqvist C, Heinonen S, Ganna A.
Lancet Digit Health. 2023 Nov;5(11):e821-e830. doi: 10.1016/S2589-7500(23)00175-9.
The association between thyroid and breast cancers: a bidirectional mendelian randomization study
Liu J, Liang L
Front Endocrinol (Lausanne). 2023 Oct 25;14:1185497. doi: 10.3389/fendo.2023.1185497
Genome-wide association study of traumatic brain injury in U.S. military veterans enrolled in the VA million veteran program
Merritt VC, Maihofer AX, Gasperi M, Chanfreau-Coffinier C, Stein MB, Panizzon MS, Hauger RL, Logue MW, Delano-Wood L, Nievergelt CM.
Mol Psychiatry. 2023 Oct 24. doi: 10.1038/s41380-023-02304-8.
Relationship between gut microbiota and intussusception: an analysis based on Mendelian randomization
Feng Cheng, Chun Luo, KeLei Shang, XiaoGuang Tan
Researchsquare, 24 October 2023, doi: 10.21203/rs.3.rs-3420042/v1
Causal association between uric acid levels and the risk of aortic aneurysm and aortic dissection: A two-sample Mendelian randomization study.
Chen J, Zhang X, Yao H, Pang J
Nutr Metab Cardiovasc Dis. 2023 Oct 24:S0939-4753(23)00427-1. doi: 10.1016/j.numecd.2023.10.020