Publikationslista

På den här sidan listar vi alla vetenskapliga publikationer som har använt data från FinnGen-studien.

2025

Juli

Genetic susceptibility to cerebral palsy involves complement system-mediated neuronal development and plasticity pathway

Huang Kun, Qi Zhou, Hao Wu, Dejiang Yang, Chongyu Xiong, Xiaowei Zhang

Sci Rep 15, 23088 (2025). https://doi.org/10.1038/s41598-025-07178-0

Investigating the potential role of EIF2S2 in OSCC progression through comprehensive bioinformatics analysis and experimental validation

Zhiwen Shao, Tao Dong, Ke Yun, Zhaohui Wang, Yu Wen, Zongli Zhang, Tao Jia

Eur J Med Res 30, 562 (2025). https://doi.org/10.1186/s40001-025-02830-x

Functional determinants and evolutionary consequences of pleiotropy in complex and Mendelian traits

Guanglei Chen, Yaxian Jin, Cancan Chu, Yuhao Zheng, Changfu Yang, Yunzhi Chen, Xing Zhu

Sci Rep 15, 21633 (2025). https://doi.org/10.1038/s41598-025-05290-9

Mendelian Randomization Analysis Reveals Causal Associations Between Autoimmune Diseases and Female Infertility Risk

Wang J, Long H, Su M, Cao Y, Zhou R, Li X, Li J, Tang Y, Tang J, Wang S, Tang L, Chen R, Deng D, Tang L.

Reprod Toxicol. 2025 Jul 2:108984. doi: 10.1016/j.reprotox.2025.108984.

Causal effects of brain subregion gene expression on inflammatory bowel diseases revealed by Mendelian randomization and single cell analysis

Li Y, Wang Y, Chen S, Liu L.

Sci Rep. 2025 Jul 1;15(1):21499. doi: 10.1038/s41598-025-08633-8.

Genetic evidence suggests a causal relationship linking thyroid function to prospective memory and dementia and Parkinson’s disease

Yang Wang, Yanying Liu,Huimin Yang, Zhuang Mo, Haiyan Liu, Qi Yu

Sci Rep 15, 21633 (2025). https://doi.org/10.1038/s41598-025-05290-9

Genetic prediction of immune cells, inflammatory proteins, and metabolite-mediated association between gut microbiota and COPD: a Mendelian randomization study

Guanglei Chen, Yaxian Jin, Cancan Chu, Yuhao Zheng, Changfu Yang, Yunzhi Chen, Xing Zhu

Sci Rep 15, 21633 (2025). https://doi.org/10.1038/s41598-025-05290-9

Association of air pollution, lifestyle factors, and metabolic syndrome: a Mendelian randomization study

Sijie Gu, Fulei Chen, Teng Li, Huanyu Hu, Mulatibieke Keerman, Qiang Niu, Heng Guo, Shuxia Guo, Jia He

Researchsquare, 01 July 2025, doi: 10.21203/rs.3.rs-6966151/v1

Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants

Franz Förster, David Emmert, Katrin Horn, Janne Pott, Johannes Frasnelli, Mohammed Aslam Imtiaz, Konstantinos Melas, Valentina Talevi, Honglei Chen, Christoph Engel, Michele Filosi, Myriam Fornage, Martin Gögele, Markus Löffler, Cristian Pattaro, Peter Pramstaller, Srishti Shrestha, N. Ahmad Aziz, Monique M. B. Breteler, Kerstin Wirkner, Markus Scholz, Christian Fuchsberger

Nat Commun 16, 5434 (2025). https://doi.org/10.1038/s41467-025-61330-y

Mendelian randomization study reveals causal association between skin microbiome and skin cancers

Yong He, Liming Li, Yuancheng Li, Xiaoke Wang, Leqi Qian, Jiajia Yang, Mingjun Jiang

Sci Rep 15, 21590 (2025). https://doi.org/10.1038/s41598-025-07265-2

Investigating the potential of oxidative stress-related gene as predictive markers in idiopathic pulmonary fibrosis

Wang Y, Zhang Z, Zhang H, Xu L, Huang S, Wen Y, Zhuang Z, Li X, Lu J, Li X.

Sci Rep. 2025 Jul 1;15(1):21228. doi: 10.1038/s41598-025-02579-7.

Causal association of antibody-mediated immune responses to infectious disease agents with lung cancer: a Mendelian randomization study

Guicai Liang, Lyubo Wang, Zhiqiang Wang, Tao Li, Lei Jiang, Yuncheng Bai, Lei Yang, Yi Feng, Yan Li, Meng Yang, Jiling Chang, Haiyue Yang, Xilong Zhou, Lincan Duan, Chunlei Ge

Discov Onc 16, 1234 (2025). https://doi.org/10.1007/s12672-025-02997-z

Gut microbiota constituents may affect hypertrophic scarring risk through interaction with specific immune cells in a two-step, two-sample Mendelian randomization study

Jiaqi Lou, Ziyi Xiang, Xiaoyu Zhu, Jiliang Li, Guoying Jin, Shengyong Cui, Neng Huang, Pei Xu, Sida Xu, Youfen Fan, Xin Le

Sci Rep 15, 20656 (2025). https://doi.org/10.1038/s41598-025-07455-y

The role of immune cells in cirrhosis: evidence from a two-sample Mendelian randomization study

Chen Y, Wang K, Liu Y, Zeng H, Long H, Kang J, Wang S, He J.

Sci Rep. 2025 Jul 1;15(1):20737. doi: 10.1038/s41598-025-07325-7.

Frailty and the Risk of Delirium: A Mendelian Randomization Study

Yu M, Li B.

Crit Care Nurs Q. 2025 Jul-Sep 01;48(3):316-324. doi: 10.1097/CNQ.0000000000000565.

Pan-cancer analysis of the impact of fatty acids: a two-sample and multivariable Mendelian randomization study

Kuang X, Wu B, Hu D, Matsika J, Cheng C, Xiao J, Cai Z, Li M, Chen J, Zhou W, Liu B.

Discov Oncol. 2025 Jul 1;16(1):1226. doi: 10.1007/s12672-025-03010-3.

Exploring the role of immune cell traits and circulating inflammatory cytokines in the development of diabetic neuropathy

Guo N, Li Q, Wang H, Li P.

Cytokine. 2025 Jul 1;194:156985. doi: 10.1016/j.cyto.2025.156985.

Loss of CFHR5 function reduces the risk for age-related macular degeneration

Reeve MP, Loomis S, Nissilä E, Soare TW, Rausch T, Zheng Z, Della Briotta Parolo P, Ben-Isvy D, Aho E, Cesetti E, Okunuki Y, McLaughlin H, Mäkelä J; FinnGen; Kurki M, Talkowski ME, Korbel JO, Connor K, Meri S, Daly MJ, Runz H.

Nat Commun. 2025 Jul 1;16(1):5766. doi: 10.1038/s41467-025-61193-3.

Proteome-wide Mendelian randomization and colocalization analysis identify therapeutic targets for stroke

Xueling Zhao, Menghao He, Desheng Zhou, Zhong Li, Lijuan Liu, Renyi Yang, Xinhua Zhu, Cuilan Gong, Siyang Yan

BMC Neurol 25, 255 (2025). https://doi.org/10.1186/s12883-025-04239-9

The mediating factors between systemic lupus erythematosus and prostate cancer risk: a two-step Mendelian randomization and transcriptome analysis

Siwen Zhong, Wei Li, Xingliang Yang, Jun Qiao, Quliang Zhong, Yuan Tian, Peng Chen, Yuewei Tao, Fa Sun, Tao Li

Discov Onc 16, 1199 (2025). https://doi.org/10.1007/s12672-025-03046-5

Juni

Investigation of potential toxicity associated with long-term amitriptyline exposure: Evidence from genomics

Liu J, Li Z, Deng Z, Wang Y, Deng F.

Ecotoxicol Environ Saf. 2025 Jun 30;302:118587. doi: 10.1016/j.ecoenv.2025.118587.

The causal and mediated relationships between major depressive disorder (MDD), post-traumatic stress disorder (PTSD), anxiety disorders and premature mortality: Evidence from genome-wide association study

Wu C, Tong S, You Y, Li Y, Cai R, Fang J, Fang X, Zhang X.

J Affect Disord. 2025 Jun 30:119781. doi: 10.1016/j.jad.2025.119781.

Genomics reveals eleven obesity endotypes with distinct biological and phenotypic signatures

Kim MS, Song M, Kim H, Park S, Shim I, Lim S, Kim B, Chen X, Sui Y, Cho SMJ, Koyama S, Yun J-S, Natarajan P, Ellinor PT, Fahed AC, Won H-H.

medRxiv 2025.06.30.25330607; doi: https://doi.org/10.1101/2025.06.30.25330607

Single-cell multi-omic integration analysis prioritizes druggable genes and reveals cell-type-specific causal effects in glioblastomagenesis

Huang Y-F, Huang K-L.

medRxiv 2025.06.28.25330486; doi: https://doi.org/10.1101/2025.06.28.25330486

Uncovering the Molecular Landscape of Physical Activity: Proteomic Insights from the UK Biobank

Qian H, Wu C, Yang Y, Li B, Rosenzweig A, Wang M.

medRxiv 2025.06.27.25330418; doi: https://doi.org/10.1101/2025.06.27.25330418

Association between gut microbiota and disorders of lipoprotein metabolism: a two sample Mendelian randomization study

Du Q, Chen Y, Kou C, Wei J, Xu R, Cao Y, Yu L, Kou X.

Nutr Metab Cardiovasc Dis. 2025 Jun 27:104212. doi: 10.1016/j.numecd.2025.104212.

Inflammatory Proteins Mediate the Effect of Gut Microbiota on Graves' Ophthalmopathy: A Mendelian Randomization Study

Li Y, Chen L, Lin S, An W, Miao L, Wan M, Zhang B.

Transl Vis Sci Technol. 2025 Jun 2;14(6):34. doi: 10.1167/tvst.14.6.34.

Genome-wide Cross-multi-trait Analysis into Shared Genetic Architecture of Coronary Artery Disease and Aortic Aneurysms

Virkkala J, FINNGEN, Kettunen J, Kaikkonen MU.

medRxiv 2025.06.27.25330395; doi: https://doi.org/10.1101/2025.06.27.25330395

Identification of Potential Therapeutic Targets for Coronary Atherosclerosis from an Inflammatory Perspective Through Integrated Proteomics and Single-Cell Omics

Wang H, Xie F, Wang M, Ji J, Song Y, Dai Y, Wang L, Kang Z, Cao L.

Int J Mol Sci. 2025 Jun 27;26(13):6201. doi: 10.3390/ijms26136201.

Glatiramer Acetate Reduces Risk of Cardiovascular Disease and Myocardial Infarction

Lehrer S, Rheinstein PH.

In Vivo. 2025 Jul-Aug;39(4):2066-2072. doi: 10.21873/invivo.14001.

Genetic associations between Serotonin Receptor 1F (HTR1F) regulatory variation and sleep apnea in non-obese individuals: Insights from GWAS and eQTL analyses

Strausz S, Broberg M, Jones SE, Koskela J, Kiiskinen T, FinnGen; Estonian Biobank Research Team; Palotie A, Palotie T, Bachour A, Saxena R, Ripatti S, Abner E, Ollila HM.

Eur Respir J. 2025 Jun 26:2401778. doi: 10.1183/13993003.01778-2024.

Genetic associations between serotonin receptor 1F (HTR1F) regulatory variation and sleep apnoea in non-obese individuals: insights from GWAS and eQTL analyses

Strausz S, Broberg M, Jones SE, Koskela J, Kiiskinen T; FinnGen; Estonian Biobank Research Team; Palotie A, Palotie T, Bachour A, Saxena R, Ripatti S, Abner E, Ollila HM.

Eur Respir J. 2025 Sep 17;66(3):2401778. doi: 10.1183/13993003.01778-2024. Print 2025 Sep.

Genetic mapping of lifespan and mitochondrial stress response in C. elegans

Li X, Li W, Gao AW, Zhu Y, Katsyuba E, Overmyer KA, Li TY, Wang Z, Legon L, Plantade L, Mouchiroud L, Cornaglia M, Li H, Houtkooper RH, Coon JJ, Auwerx J.

bioRxiv 2025.06.26.661693; doi: https://doi.org/10.1101/2025.06.26.661693

The influence of 179 lipid metabolism on head and neck cancer is mediated by 91 inflammatory factors

Hua S, Lang T, Liu R.

Community Dent Health. 2025 Jun;42(2):17-26. doi: 10.1177/0265539X251343832

Deciphering causality between social/physical activity and suicide attempt: evidence from Mendelian randomization

Li H, Yue F, Gu X, Guan H, Chen K, Zhang J, Ji H, He J.

Eur Arch Psychiatry Clin Neurosci. 2025 Jun 26. doi: 10.1007/s00406-025-02048-2.

Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression

Xiong Y, Krebs K, Jermy B, Karlsson R, Pasman JA, Nguyen TD, Gong T, Kowalec K, Rück C, Sigström R, Jonsson L, Clements CC, Hörbeck E, Andersson E, Bäckman J; FinnGen; Estonian Biobank Research Team; Ganna A, German J, Sullivan PF, Landén M, Lehto K, Lu Y.

Mol Psychiatry. 2025 Jun 26. doi: 10.1038/s41380-025-03084-z.

Uncovering Putative Causal Non-Coding RNAs in Acute and Chronic Myeloid Leukemia: A Genome-Wide Mendelian Randomization Study

Jung S, Kim JW, Han B.

Cancer Res Treat. 2025 Jun 25. doi: 10.4143/crt.2025.377.

Assessing the Causal Effect of Pulse Pressure on Migraine Risk: A Mendelian Randomization Study

Xu H, Qin X, Feng Z, You S.

J Pain Res. 2025 Jun 25;18:3159-3170. doi: 10.2147/JPR.S512795.

Identification of novel therapeutic targets for cognitive performance and associations with brain health

Lu-Yang Zhang, Yu-Xin Liu, Yun-Hui Chu, Yun-Fan You, Luo-Qi Zhou, Sheng Yang, Ming-Hao Dong, Hang Zhang, Xiao-Wei Pang, Lian Chen, Li-Fang Zhu, Jun Xiao, Ke Shang, Wei Wang, Chuan Qin, Dai-Shi Tian

Transl Psychiatry 15, 214 (2025). https://doi.org/10.1038/s41398-025-03437-w

Bayesian-weighted Mendelian randomization reveals sleep apnea syndrome mediates the BMI-chronic pain link

Shi W, Luo J, Yang L, Chen D, Zhang Y, Peng J, Ruetzler K, Sun M, Jin H.

J Thorac Dis. 2025 Jun 30;17(6):4091-4103. doi: 10.21037/jtd-2025-827.

Homocysteine and risk of interstitial lung disease: A mendelian randomization approach to causal inference

Li S, Hu X, Hu X, Liu H, Meng S.

Sarcoidosis Vasc Diffuse Lung Dis. 2025 Jun 25;42(2):16386.

The Casual Associations Between Brain Functional Networks and Fibromyalgia: A Large-Scale Genetic Correlation and Mendelian Randomization Study

Hu Y, Yang G, Deng Z, Yang S, Li Y, Xiao W, Lu B, Zhu X.

Bioengineering (Basel). 2025 Jun 25;12(7):692. doi: 10.3390/bioengineering12070692.

Causal relationship between varicose veins and hydrocele: A bidirectional two-sample Mendelian randomization study

Guo C, Qu Y, Liu H.

SAGE Open Med. 2025 Jun 25;13:20503121251338670. doi: 10.1177/20503121251338670.

Genetic Contribution of Cardiorespiratory Fitness in Morbidity and Mortality: A Prospective FinnGen and HUNT study

Joensuu L, Lukander V, Herranen P, Tynkkynen NP, Kujala U, Lopéz-Bueno R, Nordeidet AN, Klevjer M, Øvretveit K, Wisløff U, Bye A, Ekelund U, Ollikainen M, FinnGen, Sillanpää E.

medRxiv 2025.06.25.25330268; doi: https://doi.org/10.1101/2025.06.25.25330268

Multi-population GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish

Wolford BN, Zhao QY, Wu KH, Yu X, Richter CE, Bhatta L, Brumpton BM, Desch KC, Thibord F, Klarin D, Johnson AD, Tregouet DA, Damrauer SM, Smith NL, Lo Faro V, Tsuo K, Daly M, Neale B, Zhou W, Willer CJ, Shavit JA, Surakka I.

Blood Adv. 2025 Jun 24:bloodadvances.2024015790. doi: 10.1182/bloodadvances.2024015790.

Mendelian Randomization of Serum Micronutrients in relation to Lower Back Pain and Sciatica protection: focus on Vitamin A

Yan Gu, Dalong Liu, Tianyang Chen, Zihao Zhang, Zhaoliang Chen, Tianqi Gao, Chenglong Ai, Xiangyang Leng

Researchsquare, 24 June 2025, doi: 10.21203/rs.3.rs-6809845/v1

Causal Associations Between Socioeconomic Status, Intelligence, Cognition and Atrial Fibrillation: Evidence From Mendelian Randomization

Kaisaier W, Ye M, Wu Z, Liu C, He J, Lip GYH, Chen Y, Zhu W.

JACC Asia. 2025 Jun 2:S2772-3747(25)00265-0. doi: 10.1016/j.jacasi.2025.04.008.

Causal Associations Between 141 Gut Microbiota Taxa and 14 Rheumatic Diseases: A Mendelian Randomization Study

Hu Y, He H, Zhang Y, Lyu H, Zeng C, Wei J, Lei G.

Int J Rheum Dis. 2025 Jun;28(6):e70334. doi: 10.1111/1756-185X.70334.

Mendelian Randomization Analyses Support Causal Relationship between Brain Imaging-derived Phenotypes and Risk of Low Back Pain

Xie XY, Lin JW, Fang JY, Chen ZC, Li PC, Huang XY, Guo MY, Lin LL, Cao MH.