Publikationslista

Portas L, Talaei M, Dean C, Aung N, Hind MD, Pozarickij A, Walters RG; China Kadoorie Biobank Collaborative Group; Burney PG, Petersen S, Minelli C, Shaheen SO.

Thorax. 2025 May 30:thorax-2024-222474. doi: 10.1136/thorax-2024-222474.

Unveiling the Intricate Causal Nexus Between 91 Circulating Inflammatory Proteins and Perianal Abscess Through a Comprehensive Bidirectional Two-Sample Mendelian Randomization Analysis

Wang Z, Chen T, Shi H, Zhang X, Yang W.

Health Sci Rep. 2025 May 29;8(6):e70803. doi: 10.1002/hsr2.70803.

From infection to tumor: genetic evidence of viral antibody immune response' role in urologic cancer development

Wang C, Zhang Q, Li Q, Wang Y, Chen X.

Discov Oncol. 2025 May 29;16(1):947. doi: 10.1007/s12672-025-02768-w.

Multi-Omics Mendelian Randomization Identifies Therapeutic Targets for Sjögren’s Disease with Clinical and Bayesian Validation

He J, Li K, Guo Z, Zhou X, Tang X.

J Inflamm Res. 2025;18:16685-16698 https://doi.org/10.2147/JIR.S543644

Decoding the impact of glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist on cardiometabolic health: inflammatory mediators at the focus

Cheng F, Niu X, Wang Y, Yang F, Yang K, Li W.

Diabetol Metab Syndr. 2025 May 28;17(1):175. doi: 10.1186/s13098-025-01744-2.

Association of glucagon-like peptide-1 receptor agonists and seven common mental disorders: A drug target and mediation Mendelian randomization

Zhang Z, Li S, Dai X, Li C, Sun P, Qu J, Jiang H, Pan B.

J Affect Disord. 2025 May 28:119509. doi: 10.1016/j.jad.2025.119509.

The Mediating Role of Plasma Inflammatory Proteins in Gut Microbiota-Driven Valvular Heart Disease: A Mendelian Randomization Study

Zhao J, Wang Y, Lv C, Peng J, Lu S, Shen L.

Cell Biochem Biophys. 2025 May 28. doi: 10.1007/s12013-025-01780-9.

Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization study

Wang N, Wang T, Tang M, Zu B, Chen J.

BMC Pregnancy Childbirth. 2025 May 28;25(1):622. doi: 10.1186/s12884-025-07754-2.

Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability

Drouard G, Hagenbeek FA, Ollikainen M, Zheng Z, Wang X; FinnGen; Ripatti S, Pirinen M, Kaprio J.

J Proteome Res. 2025 May 27. doi: 10.1021/acs.jproteome.4c00971.

Sleep disturbances as risk factors for neurodegeneration later in life

Simmonds E, Levine KS, Han J, Iwaki H, Koretsky MJ, Kuznetsov N, Faghri F, Warly Solsberg C, Schuh A, Jones L, Bandres-Ciga S, Blauwendraat C, Singleton A, Escott-Price V, Leonard HL, Nalls MA.

npj Dement. 1, 6 (2025). https://doi.org/10.1038/s44400-025-00008-0

Variant-specific priors clarify colocalisation analysis

Pullin JM, Wallace C.

PLoS Genet. 2025 May 27;21(5):e1011697. doi: 10.1371/journal.pgen.1011697.

Higher body mass index is a causal risk factor for skin infections: a Mendelian randomisation study using UK Biobank and FinnGen

Hopkins R, de Villiers E, Weedon MN, Shields BM, Dennis JM, McGovern AP, Green HD.

medRxiv 2025.05.27.25328427; doi: https://doi.org/10.1101/2025.05.27.25328427

Variant-specific priors clarify colocalisation analysis

Pullin JM, Wallace C.

PLoS Genet. 2025 May 27;21(5):e1011697. doi: 10.1371/journal.pgen.1011697.

Genetic liability to sedentary behaviour and cardiovascular disease incidence in the FinnGen and HUNT cohorts

Joensuu L, Koivunen K, Tynkkynen NP, Palviainen T, Kaprio J; FinnGen Consortium; Klevjer M, Øvretveit K, Wisløff U, Bye A, Ekelund U, Sillanpää E.

Br J Sports Med. 2025 May 27;59(11):783-790. doi: 10.1136/bjsports-2024-109491.

Therapeutic targets for venous thromboemblism: proteome-wide mendelian randomization and colocalization analyses

Li X, Yang CH, Zhou M, Yin MY.

Thromb J. 2025 May 26;23(1):54. doi: 10.1186/s12959-025-00733-9.

Association of lipid-lowering drugs with venous thromboembolism outcomes: a phenome-wide association study and a drug-target Mendelian randomization study

Lingyu Z, Wanting Z, Ying G, Qianqian J, Chunfang W.

J Thromb Thrombolysis. 2025 May 26. doi: 10.1007/s11239-025-03108-z.

Contextualizing molecular and structural aging across human organs

Shu J, Guo Y, Chirinos J, Fan Z, Yang Y, Li Y, Yang X, Beeche C, Su B, Horng I, Zheng R, Paschou P, Wang L-S, O’Brien JM, Gur R, Lin J, Witschey W, Rader DJ, Rosenzweig A, Zhao B.

medRxiv 2025.05.26.25328375; doi: https://doi.org/10.1101/2025.05.26.25328375

Screening of biobank SNP-array genotyping data to detect Lynch syndrome predisposing MLH1 copy number variants

Ala-Kulju K, Carpén O, Lappalainen M, Pehrsson M.

Fam Cancer. 2025 May 26;24(2):47. doi: 10.1007/s10689-025-00476-6.

Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk

MULTI consortium; Anagnostakis F, Ko S, Saadatinia M, Wang J, Davatzikos C, Wen J.

Nat Commun. 2025 May 26;16(1):4871. doi: 10.1038/s41467-025-59964-z.

Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics

Lobato-Moreno S, Yildiz U, Claringbould A, Servaas NH, Vlachou EP, Arnold C, Bauersachs HG, Campos-Fornés V, Kim M, Berest I, Prummel KD, Noh KM, Marttinen M, Zaugg JB.

Nat Methods. 2025 Jun;22(6):1213-1225. doi: 10.1038/s41592-025-02700-8.

Metabolomics insights into the causal associations between antihypertensive drugs and myocarditis

Hu X, Hu T, Ye Y, Chen X, Abulikemu S, Yu J, Zhao Y, Wang J, Peng Y.

Int Immunopharmacol. 2025 May 26;159:114946. doi: 10.1016/j.intimp.2025.114946.

Causal relationship between citrate and gestational diabetes mellitus: a two-sample Mendelian randomization analysis

He Y, Gan Y, Mao J, Shi Q.

J Matern Fetal Neonatal Med. 2025 Dec;38(1):2509160. doi: 10.1080/14767058.2025.2509160.

Causal relationships between white matter connectome and mental disorders: a large-scale genetic correlation study

Zhao Z, Zhang B, Gan R, Xie H, Shao Y, Xu K, Jia Z.

J Affect Disord. 2025 May 24;386:119469. doi: 10.1016/j.jad.2025.119469.

Unraveling drug resistance mechanisms in testicular cancer through immune cell phenotypes: a bidirectional Mendelian randomization analysis revealing novel therapeutic targets

Xiao L, Wu T.